公开(公告)号：EP3154966B1

公开(公告)日：2019-05-08

申请号：EP15730666.3

申请日：2015-06-12

申请人： The U.S.A. as represented by the Secretary, Department of Health and Human Services ,  University of Kansas

发明人： LIANG,Tsanyang ,  HU, Zongyi ,  MARUGAN, Juan Jose ,  SOUTHALL, Noel Terrence ,  HE, Shanshan ,  HU, Xin ,  XIAO, Jingbo ,  FERRER, Marc ,  ZHENG, Wei ,  FRANKOWSKI, Kevin J. ,  SCHOENEN, Frank J. ,  LI, Kelin

IPC分类号： C07D413/14 ,  C07D471/08 ,  A61K31/553 ,  A61P31/14

公开(公告)号：EP3154966A1

公开(公告)日：2017-04-19

申请号：EP15730666.3

申请日：2015-06-12

申请人： The U.S.A. as represented by the Secretary, Department of Health and Human Services ,  University of Kansas

发明人： LIANG,Tsanyang ,  HU, Zongyi ,  MARUGAN, Juan Jose ,  SOUTHALL, Noel Terrence ,  HE, Shanshan ,  HU, Xin ,  XIAO, Jingbo ,  FERRER, Marc ,  ZHENG, Wei ,  FRANKOWSKI, Kevin J. ,  SCHOENEN, Frank J. ,  LI, Kelin

IPC分类号： C07D413/14 ,  C07D471/08 ,  A61K31/553 ,  A61P31/14

CPC分类号： C07D413/06 ,  A61K31/4178 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/7056 ,  A61K31/7068 ,  A61K38/07 ,  A61K38/13 ,  A61K38/212 ,  C07D413/14 ,  C07D417/14 ,  C07D471/08 ,  Y02A50/385

摘要： Disclosed are compounds of formula (I), formula (II), and formula (III): wherein Ar, R1, A, and X are as defined in the specification. These compounds are antiviral agents and are contemplated for use in the treatment of viral infections, for example, hepatitis C. These compounds are also contemplated for use in treating or preventing cancers.

摘要翻译： 公开了式（I），式（II）和式（III）的化合物：其中Ar，R 1，A和X如说明书中所定义。 这些化合物是抗病毒剂，并且被考虑用于治疗病毒感染，例如丙型肝炎。这些化合物也被考虑用于治疗或预防癌症。

公开(公告)号：EP2566480A2

公开(公告)日：2013-03-13

申请号：EP11778469.4

申请日：2011-05-06

申请人： California Institute of Technology ,  Cleave Biosciences, Inc. (Cleave) ,  THE UNIVERSITY OF KANSAS

发明人： DESHAIES, Raymond, J. ,  CHOU, Tsui-fen ,  SCHOENEN, Frank, J. ,  LI, Kelin ,  FRANKOWSKI, Kevin, J. ,  AUBE, Jeffrey ,  GERRITZ, Samuel, W. ,  ZHOU, Han-jie

IPC分类号： A61K31/517 ,  A61K31/53 ,  A61K31/4184 ,  A61P35/00

CPC分类号： A61K31/517 ,  A61K31/4184 ,  A61K31/53 ,  A61K31/538 ,  C12Q1/42 ,  C12Q1/485 ,  G01N2500/02

摘要： Compounds of Formulas I-XLIII are identified as direct inhibitors of p97 ATPase or of the degradation of a p97-dependent ubiquitin-proteasome system (UPS) substrate. Methods and compositions are disclosed for inhibiting p97 ATPase and the degradation of a p97-dependent UPS substrate, and for identifying inhibitors thereof