公开(公告)号：EP3237385A1

公开(公告)日：2017-11-01

申请号：EP15823901.2

申请日：2015-12-22

申请人： The United States of America, as represented by The Secretary, Department of Health and Human Services ,  The University of North Carolina at Chapel Hill

发明人： BOXER, Matthew Brian ,  ROHDE, Jason Matthew ,  PRAGANI, Rajan ,  LIU, Li ,  DAVIS, Mindy Irene Emily ,  BRIMACOMBE, Kyle Ryan ,  SHEN, Min ,  SIMEONOV, Anton ,  KARAVADHI, Surendra ,  URBAN, Daniel Jason ,  JADHAV, Ajit ,  WANG, Xiaodong ,  MCIVER, Andrew Louis

IPC分类号： C07D215/22 ,  C07D401/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  A61K31/4545 ,  A61K31/4436 ,  A61K31/4704 ,  A61K31/4725 ,  A61K31/5377 ,  A61K31/55 ,  A61P35/00

CPC分类号： C07D471/04 ,  C07D215/22 ,  C07D215/54 ,  C07D401/04 ,  C07D401/14 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/14 ,  C07D487/08 ,  C07D487/10 ,  C07D491/052 ,  C07D491/107

摘要： Compounds of Formula I and Formula II and the pharmaceutically acceptable salts thereof are disclosed The variables A, B, Y, Z, X
1 , X
2 , R
1-4 and R
13-18 are disclosed herein. The compounds are useful for treating cancer disorders, especially those involving mutant IDH1 enzymes. Pharmaceutical compositions containing compounds of Formula I or Formula II and methods of treatment comprising administering compounds of Formula I and Formula II are also disclosed.

摘要翻译： 式I和式II化合物及其药学上可接受的盐公开于此。变量A，B，Y，Z，X 1，X 2，R 1-4和R 13-18在本文中公开。 这些化合物可用于治疗癌症疾病，尤其是那些涉及突变IDH1酶的疾病。 还公开了含有式I或式II化合物的药物组合物和包含给予式I和式II化合物的治疗方法。

公开(公告)号：EP2858648B1

公开(公告)日：2018-08-22

申请号：EP13800857.8

申请日：2013-06-07

申请人： Beth Israel Deaconess Medical Center, Inc. ,  The United States of America as represented by the Secretary, Department of Health and Human Services

发明人： LU, Kun, Ping ,  BOXER, Matthew, Brian ,  DAVIS, Mindy Irene, Emily ,  PRAGANI, Rajan ,  SHEN, Min ,  SIMEONOV, Anton, Momtchilov ,  WEI, Shuo ,  ZHOU, Xiao, Zhen

IPC分类号： A61K31/473 ,  C12N9/90 ,  A61P35/00 ,  A61P29/00

CPC分类号： A61K31/5377 ,  A61K31/185 ,  A61K31/341 ,  A61K31/357 ,  A61K31/365 ,  A61K31/381 ,  A61K31/382 ,  A61K31/402 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/405 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/428 ,  A61K31/4704 ,  A61K31/473 ,  A61K31/496 ,  A61K45/06 ,  A61K2300/00

摘要： The invention features compositions and methods for inhibiting the Pin1 protein, and the treatment of disorders characterized by elevated Pin1 levels.

公开(公告)号：EP2858648A1

公开(公告)日：2015-04-15

申请号：EP13800857.8

申请日：2013-06-07

申请人： Beth Israel Deaconess Medical Center, Inc. ,  The United States of America as Represented by the Secretary, Department of Health and Human Services

发明人： LU, Kun, Ping ,  BOXER, Matthew, Brian ,  DAVIS, Mindy Irene, Emily ,  PRAGANI, Rajan ,  SHEN, Min ,  SIMEONOV, Anton, Momtchilov ,  WEI, Shuo ,  ZHOU, Xiao, Zhen

IPC分类号： A61K31/473 ,  C12N9/90

CPC分类号： A61K31/5377 ,  A61K31/185 ,  A61K31/341 ,  A61K31/357 ,  A61K31/365 ,  A61K31/381 ,  A61K31/382 ,  A61K31/402 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/405 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/428 ,  A61K31/4704 ,  A61K31/473 ,  A61K31/496 ,  A61K45/06 ,  A61K2300/00

摘要： The invention features compositions and methods for inhibiting the Pin1 protein, and the treatment of disorders characterized by elevated Pin1 levels.

摘要翻译： 本发明的特征在于用于抑制Pin1蛋白的组合物和方法，以及治疗以Pin1水平升高为特征的病症。

公开(公告)号：EP3475276A1

公开(公告)日：2019-05-01

申请号：EP17735296.0

申请日：2017-06-21

申请人： The U.S.A. as represented by the Secretary, Department of Health and Human Services ,  The University Of North Carolina At Chapel Hill

发明人： BOXER, Matthew Brian ,  WANG, Xiaodong ,  BRIMACOMBE, Kyle Ryan ,  EMILY DAVIS, Mindy Irene ,  FANG, Yuhong ,  HALL, Matthew ,  JADHAV, Ajit ,  KARAVADHI, Surendra ,  LIU, Li ,  MARTINEZ, Natalia ,  MCIVER, Andrew Louis ,  PRAGANI, Rajan ,  ROHDE, Jason Matthew ,  SIMEONOV, Anton ,  ZHAO, Wei ,  SHEN, Min

IPC分类号： C07D417/04 ,  C07D417/14 ,  C07D487/08 ,  A61K31/497 ,  A61K31/4995 ,  A61P35/00