公开(公告)号：EP3906939A1

公开(公告)日：2021-11-10

申请号：EP21161239.5

申请日：2014-10-10

申请人： The United States of America, represented by the Secretary, Department of Health and Human Services

发明人： KANEKIYO, Masaru ,  NABEL, Gary J. ,  COHEN, Jeffrey ,  BU, Wei

IPC分类号： A61K39/12

摘要： Novel vaccines are provided that elicit neutralizing antibodies to Epstein-Barr virus (EBV). Some vaccines comprise nanoparticles that display envelope proteins from EBV on their surface. The nanoparticles comprise fusion proteins comprising a monomeric subunit of a self-assembly protein, such as ferritin, joined to at least a portion of an EBV envelope protein. The fusion proteins self-assemble to form the envelope protein-displaying nanoparticles. Such vaccines can be used to vaccinate an individual against infection by different types of Epstein-Barr viruses as well as Epstein-Barr viruses that are antigenically divergent from the virus from which the EBV envelope protein was obtained. Also provided are fusion proteins and nucleic acid molecules encoding such proteins.

公开(公告)号：EP3054971A1

公开(公告)日：2016-08-17

申请号：EP14799574.0

申请日：2014-10-10

申请人： The United States of America, represented by the Secretary, Department of Health and Human Services

发明人： KANEKIYO, Masaru ,  NABEL, Gary, J. ,  COHEN, Jeffrey ,  BU, Wei

IPC分类号： A61K39/12

CPC分类号： A61K39/245 ,  A61K39/12 ,  A61K2039/55505 ,  A61K2039/575 ,  A61K2039/64 ,  C07K14/00 ,  C07K14/005 ,  C07K14/195 ,  C07K16/085 ,  C07K2317/33 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/40 ,  C07K2319/735 ,  C12N7/00 ,  C12N2710/16222 ,  C12N2710/16234 ,  C12N2710/16271

摘要： Vaccines are provided that elicit neutralizing antibodies to Epstein- Barr virus (EBV). Some vaccines comprise nanoparticles that display envelope proteins from EBV on their surface. The nanoparticles comprise fusion proteins comprising a monomeric subunit of a self- assembly protein, such as ferritin, joined to at least a portion of an EBV envelope protein. The fusion proteins self-assemble to form the envelope protein-displaying nanoparticles. Such vaccines can be used to vaccinate an individual against infection by different types of Epstein-Barr viruses as well as Epstein-Barr viruses that are antigenically divergent from the virus from which the EBV envelope protein was obtained. Also provided are fusion proteins and nucleic acid molecules encoding such proteins.

摘要翻译： 提供了引发Epstein-Barr病毒（EBV）中和抗体的疫苗。 一些疫苗包括在其表面上显示来自EBV的包膜蛋白的纳米颗粒。 纳米颗粒包含融合蛋白，其包含与EBV包膜蛋白的至少一部分连接的自组装蛋白（例如铁蛋白）的单体亚基。 融合蛋白自组装形成包膜蛋白显示纳米粒子。 这样的疫苗可以用于接种个体，以抵抗不同类型的爱泼斯坦 - 巴尔病毒感染，以及从获得EBV包膜蛋白的病毒中抗原性发散的爱泼斯坦 - 巴尔病毒。 还提供了编码这种蛋白质的融合蛋白和核酸分子。