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公开(公告)号:EP2736523A1
公开(公告)日:2014-06-04
申请号:EP12818199.7
申请日:2012-07-27
发明人: FAIRLIE, David Paul , LIU, Ligong , YAU, Mei-Kwan , SUEN, Jacky Yung , REID, Robert , LOHMAN, Rink-Jan , IYER, Abishek Venkatasubramanian , LIM, Junxian , BROWN, Lindsay Charles
IPC分类号: A61K38/05 , A61K38/06 , C07K5/065 , C07K5/062 , C07K5/078 , C07K5/083 , A61P9/00 , A61P3/04 , A61P5/00
CPC分类号: C07K5/08 , A61K38/05 , C07K5/02 , C07K5/06 , C07K5/06078
摘要: The present invention provides novel compounds of the Formula (I), pharmaceutical compositions comprising such compounds and methods for using such compounds as tools for biological studies or as agents or drugs for therapies such as metabolic syndrome, obesity, type II diabetes, fibrosis and cardiovascular diseases, whether they are used alone or in combination with other treatment modalities.
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公开(公告)号:EP4267539A1
公开(公告)日:2023-11-01
申请号:EP21908163.5
申请日:2021-12-23
发明人: FAIRLIE, David , LIU, Ligong , REID, Robert , MAK, Jeffrey
IPC分类号: C07C20060101
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公开(公告)号:EP2598517B1
公开(公告)日:2019-06-26
申请号:EP11811656.5
申请日:2011-07-28
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公开(公告)号:EP2598517A1
公开(公告)日:2013-06-05
申请号:EP11811656.5
申请日:2011-07-28
IPC分类号: C07K5/065 , A61K38/05 , A61K38/06 , A61P1/00 , A61P3/00 , A61P7/00 , A61P9/00 , A61P11/00 , A61P13/00 , A61P17/00 , A61P19/00 , A61P21/00 , A61P25/00 , A61P29/00 , A61P37/00 , C07K5/062 , C07K5/078 , C07K5/083
CPC分类号: C07K5/0812 , A61K38/00 , C07K5/00 , C07K5/06034 , C07K5/06078 , C07K5/0806 , C07K5/0808 , C07K5/081 , C07K5/0823 , C07K5/0825
摘要: The present invention provides novel compounds of the Formula (1), pharmaceutical compositions comprising such compounds and methods for using such compounds as tools for biological studies or as agents or drugs for modulating Protease Activated Receptor-2 (PAR2) and for treating a subject at risk of—or susceptible to—a disease or disorder, or having a disease or disorder associated with undesirable PAR2 activity.
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