公开(公告)号：EP1883522A2

公开(公告)日：2008-02-06

申请号：EP06849766.8

申请日：2006-05-03

申请人： The University of Akron

发明人： RENEKER, Darrell, H. ,  CHASE, George ,  KATAPHINAN, Woraphon ,  DOSUNMU, Oludotun

IPC分类号： B29C45/20

CPC分类号： D01D5/0069

摘要： The present invention relates to methods for producing fibers made from one or more polymers or polymer composites, and to structures that can be produced from such fibers. In one embodiment, the fibers of the present invention are nanofibers. The present invention also relates to apparatus for producing fibers made from one or more polymers or polymer composites, and methods by which such fibers are made.

公开(公告)号：EP2015803A2

公开(公告)日：2009-01-21

申请号：EP07835752.2

申请日：2007-05-09

申请人： APOGEE TECHNOLOGY, INC. ,  The University of Akron

发明人： RENEKER, Darrell, H. ,  SMITH, Daniel, J. ,  MEYERS, David, Barrett ,  GOLUBOVIC-LIAKOPOULOS, Nevenka ,  MARIN, Alexander ,  ANDRIANOV, Alexander, K. ,  CARROLL, Peter, G. ,  SIMON, Sanford, R. ,  HAN, Tao

IPC分类号： A61M5/00 ,  A61M5/162 ,  A61M5/31

CPC分类号： A61K9/70 ,  A61K9/0021 ,  A61K38/29 ,  A61K38/465 ,  A61K39/07 ,  A61K2039/54

摘要： A device which comprises a substrate which includes a plurality of asperities, such as microneedles, extending from the surface of the substrate, and an electrospun material in contact with the substrate. The electrospun material may comprise a plurality of nanofibers which carry at least one biologically active agent. Such devices are useful as transdermal delivery devices for delivering pharmaceuticals and other biologically active agents.

摘要翻译： 一种装置，该装置包括一个基底，该基底包括从该基底表面延伸的多个诸如微针之类的粗糙体，以及与该基底接触的静电纺丝材料。 电纺材料可以包含多个携带至少一种生物活性剂的纳米纤维。 这种装置可用作递送药物和其他生物活性剂的透皮递送装置。

公开(公告)号：EP1624953B1

公开(公告)日：2018-12-19

申请号：EP04760164.6

申请日：2004-04-23

申请人： The University of Akron

发明人： RENEKER, Darrell, H. ,  SMITH, Daniel, J.

IPC分类号： A61F13/00 ,  A61K9/70

CPC分类号： A61K9/70 ,  Y10T442/2525

摘要： A fibrous assembly is provided for performing site-specific chemistry. In general, the present invention provides a fibrous assembly comprising a first nanofiber that sequesters a first reactive component, wherein the first nanofiber is prepared by an electrospinning or gas-jet method, wherein the first nanofiber releases its reactive component when the nanofiber is in the presence of a releasing agent and the first reactive component and the releasing agent chemically react to produce a reaction product. Related methods of manufacture and use are also disclosed.

公开(公告)号：EP1883522B1

公开(公告)日：2011-01-05

申请号：EP06849766.8

申请日：2006-05-03

申请人： The University of Akron

发明人： RENEKER, Darrell, H. ,  CHASE, George ,  KATAPHINAN, Woraphon ,  DOSUNMU, Oludotun

IPC分类号： B29C45/20 ,  D01D5/00

CPC分类号： D01D5/0069

摘要： The present invention relates to methods for producing fibers made from one or more polymers or polymer composites, and to structures that can be produced from such fibers. In one embodiment, the fibers of the present invention are nanofibers. The present invention also relates to apparatus for producing fibers made from one or more polymers or polymer composites, and methods by which such fibers are made.

公开(公告)号：EP1718245A2

公开(公告)日：2006-11-08

申请号：EP05713445.4

申请日：2005-02-14

申请人： The University of Akron

发明人： RENEKER, Darrell, H. ,  SMITH, Daniel, J. ,  KATAPHINAN, Woraphon

IPC分类号： A61F2/06

CPC分类号： A61F2/06 ,  A61F2/0063 ,  A61F2/82 ,  A61F2002/0086 ,  A61F2002/009 ,  A61L27/34 ,  A61L31/14 ,  A61L2400/12 ,  Y10T442/10

摘要： The present invention relates to nanofibrous coatings on medical devices such a surgical mesh or stent, wherein the coating is mechanically attached to the device. The principal mechanism for attaching the coating is through causing the fibers to permeate and entangle with the substrate.

公开(公告)号：EP1713417A2

公开(公告)日：2006-10-25

申请号：EP05723009.6

申请日：2005-02-14

申请人： The University of Akron

发明人： RENEKER, Darrell, H. ,  SMITH, Daniel, J. ,  KATAPHINAN, Woraphon

IPC分类号： A61F2/06

CPC分类号： A61F2/82 ,  A61B17/12022 ,  A61B17/12118 ,  A61B2017/00889 ,  A61B2017/00893 ,  A61F2250/0067 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/418 ,  A61L2400/04 ,  A61L2420/04 ,  A61M25/1027 ,  A61M2025/1088

摘要： The present invention is directed to a medical device, such as a stent, having a coating comprising a release component and an insoluble fibrous component. The release component is capable of being degraded thus leaving a gap between the stent and the insoluble fibrous component. Further, the insoluble fibrous component is capable of being wrapped about the stent, and capable of moving substantially freely about the stent upon degradation of the release component. This capacity enables the insoluble fibrous component to form a reinforced thrombus plug in, for instance, an aneurysm or fistula.

公开(公告)号：EP1624953A2

公开(公告)日：2006-02-15

申请号：EP04760164.6

申请日：2004-04-23

申请人： The University of Akron ,  Reneker, Darrell H. ,  Smith, Daniel J.

发明人： RENEKER, Darrell, H. ,  SMITH, Daniel, J.

IPC分类号： B01F1/00 ,  A61F13/00

CPC分类号： A61K9/70 ,  Y10T442/2525

摘要： A fibrous assembly is provided for performing site-specific chemistry. In general the present invention provides a fibrous assembly comprising a first fiber that sequesters a first reactive component; and a second fiber that sequesters a second reactive component, wherein at least the first or second fiber releases its reactive component when the fiber is in the presence of a releasing agent, and wherein when the at least first or second fiber releases its reactive component, the first and second reactive components react with each other to form a reaction product. Related methods of manufacture and use are also provided.