公开(公告)号：EP4281562A1

公开(公告)日：2023-11-29

申请号：EP22770742.9

申请日：2022-03-18

申请人： The University of British Columbia ,  INCISIVE GENETICS, INC.

发明人： LEAVITT, Blair ,  HILL, Austin ,  WAGNER, Pamela

IPC分类号： C12N15/113 ,  A61K31/7088 ,  A61K31/7105 ,  A61K38/46 ,  C12N9/22 ,  C12N15/10 ,  C12N15/11 ,  C12N15/87 ,  C12N15/90 ,  C12Q1/68

公开(公告)号：EP4379053A2

公开(公告)日：2024-06-05

申请号：EP24156927.6

申请日：2019-10-09

申请人： The University of British Columbia

发明人： KULKARNI, Jayesh ,  HILL, Austin ,  CULLIS, Pieter ,  LEAVITT, Blair ,  PETKAU, Terri ,  WAGNER, Pamela

IPC分类号： C12N15/11

CPC分类号： A61P25/28 ,  A61P25/16 ,  C12N15/113 ,  C12N15/88 ,  C12N2310/2020170501 ,  C12N15/111 ,  C12N2310/1420130101 ,  A61K9/1272 ,  A61K9/0019

摘要： Lipid-based vesicles, typically herein called transfection competent vesicles (TCVs), configured to safely and efficiently deliver DNA, RNA, other nucleic acid and protein cargoes into target cells. The safety and efficiency are each, and both, achieved in part by eliminating organic solvents such as ethanol and detergents such as sodium dodecyl sulfate from the TCV loading processes (i.e., inserting a cargo into the TCV), TCV storage processes, and/or TCV delivery processes. The cargoes can also comprise nucleic acids complexed with a protein, such as a ribonucleoprotein (RNP). The systems, compositions, devices and methods, etc., herein, in some embodiments, can provide empty TCVs that can if desired be loaded at the bench without use of specialized equipment.

公开(公告)号：EP4379053A3

公开(公告)日：2024-09-18

申请号：EP24156927.6

申请日：2019-10-09

申请人： The University of British Columbia

发明人： KULKARNI, Jayesh ,  HILL, Austin ,  CULLIS, Pieter ,  LEAVITT, Blair ,  PETKAU, Terri ,  WAGNER, Pamela

IPC分类号： C12N15/88 ,  C12N9/22 ,  C12N15/113 ,  A61K9/50 ,  A61K47/12 ,  A61K47/14 ,  A61P25/16 ,  A61P25/28 ,  A61K9/00 ,  A61K9/127 ,  C12N15/11

CPC分类号： A61P25/28 ,  A61P25/16 ,  C12N15/113 ,  C12N15/88 ,  C12N2310/2020170501 ,  C12N15/111 ,  C12N2310/1420130101 ,  A61K9/1272 ,  A61K9/0019

摘要： Lipid-based vesicles, typically herein called transfection competent vesicles (TCVs), configured to safely and efficiently deliver DNA, RNA, other nucleic acid and protein cargoes into target cells. The safety and efficiency are each, and both, achieved in part by eliminating organic solvents such as ethanol and detergents such as sodium dodecyl sulfate from the TCV loading processes (i.e., inserting a cargo into the TCV), TCV storage processes, and/or TCV delivery processes. The cargoes can also comprise nucleic acids complexed with a protein, such as a ribonucleoprotein (RNP). The systems, compositions, devices and methods, etc., herein, in some embodiments, can provide empty TCVs that can if desired be loaded at the bench without use of specialized equipment.

公开(公告)号：EP4409004A1

公开(公告)日：2024-08-07

申请号：EP22889548.8

申请日：2022-11-02

申请人： The University of British Columbia ,  INCISIVE GENETICS, INC.

发明人： LEAVITT, Blair ,  HILL, Austin ,  WAGNER, Pamela ,  CARON, Nicholas

IPC分类号： C12N15/113 ,  A61K9/50 ,  A61K31/7105 ,  A61K31/7125 ,  A61K38/46 ,  A61P7/00 ,  C12N9/22 ,  C12N15/10 ,  C12N15/63

CPC分类号： A61K31/7105 ,  A61K31/7125 ,  A61P7/00 ,  C12N9/22 ,  C12N15/113 ,  C07K14/805 ,  C12N2310/2020170501 ,  C12N2320/3220130101 ,  A61K9/5068 ,  C12N15/907 ,  A61K48/005

公开(公告)号：EP3864163A1

公开(公告)日：2021-08-18

申请号：EP19871608.6

申请日：2019-10-09

申请人： The University of British Columbia

发明人： KULKARNI, Jayesh ,  HILL, Austin ,  CULLIS, Pieter ,  LEAVITT, Blair ,  PETKAU, Terri ,  WAGNER, Pamela

IPC分类号： C12N15/88 ,  C12N9/22 ,  C12N15/113 ,  A61K9/50 ,  A61K47/12 ,  A61K47/14 ,  A61P25/16 ,  A61P25/28