公开(公告)号：EP4141017A1

公开(公告)日：2023-03-01

申请号：EP21792412.5

申请日：2021-04-23

申请人： The University of Tokyo ,  Savid Therapeutics Inc. ,  Tohoku University

发明人： KANAI, Motomu ,  YAMATSUGU, Kenzo ,  TATSUMI, Toshifumi ,  KODAMA, Tatsuhiko ,  SUGIYAMA, Akira ,  TSUKAGOSHI, Masanobu ,  TOKUYAMA, Hidetoshi ,  SAKATA, Juri

IPC分类号： C07K5/04 ,  A61K38/05 ,  A61K47/62 ,  A61K47/68 ,  A61P35/00 ,  C07K7/04 ,  C07K19/00

摘要： It is an object of the present invention to provide a conjugate of a duocarmycin derivative and a biotin-modified dimer, which is useful for pretargeting methods. According to the present invention, a compound represented by the following formula (1) or formula (2) is provided:


wherein R 1 and R 2 each independently represent a hydrogen atom, a lower alkyl group, or a lower alkoxycarbonyl group; one of R 3 , R 4 , and R 5 represents -O-L 7 -(Xaa) m -L 6 -N 3 , and the remaining two each independently represent a hydrogen atom, a lower alkyl group, or a lower alkoxycarbonyl group; X represents a reactive group; L 6 and L 7 each independently represent a divalent linking group; Xaa represents an amino acid residue; m represents an integer of 2 to 10; and Me represents a methyl group.

公开(公告)号：EP3348648B1

公开(公告)日：2020-08-19

申请号：EP16844345.5

申请日：2016-09-06

申请人： Kirin Holdings Kabushiki Kaisha ,  The University of Tokyo ,  Tohoku University

发明人： TSUJI, Toshikazu ,  IKADO, Kumiko ,  YAMADA, Sayuri ,  UCHIYAMA, Seiichi ,  KAWAMOTO, Kyoko ,  TOKUYAMA, Hidetoshi ,  OKANO, Kentaro

IPC分类号： C07D233/24 ,  A61K9/51 ,  C08F212/12 ,  C08F222/10 ,  C08F122/38

公开(公告)号：EP3760193A1

公开(公告)日：2021-01-06

申请号：EP20191485.0

申请日：2016-09-06

申请人： Kirin Holdings Kabushiki Kaisha ,  The University of Tokyo ,  Tohoku University

发明人： TSUJI, Toshikazu ,  IKADO, Kumiko ,  YAMADA, Sayuri ,  UCHIYAMA, Seiichi ,  KAWAMOTO, Kyoko ,  TOKUYAMA, Hidetoshi ,  OKANO, Kentaro

IPC分类号： A61K9/51 ,  C08F212/12 ,  C08F222/10 ,  C08F122/38 ,  C07D233/24

摘要： An intracellular delivery vehicle of which surface is covered by a positive charge, an intracellular delivery complex in which a component or compound desired is loaded in the intracellular delivery vehicle, a temperature-sensitive probe comprising the intracellular delivery complex, and a method for measuring the intracellular temperature by the temperature-sensitive probe are disclosed. The intracellular delivery vehicle is useful on account of its capability of easily delivering the component or compound desired inside the cell without inhibiting cell proliferation.