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    Improved vaccines and methods for using the same
    7.
    发明公开
    Improved vaccines and methods for using the same 有权
    Verbesserte端粒酶 - Impfstoffe

    公开(公告)号：EP2708549A2

    公开(公告)日：2014-03-19

    申请号：EP13187666.6

    申请日：2007-07-30

    申请人： The Trustees of The University of Pennsylvania

    发明人： Weiner, David B. ,  Yan, Jian

    IPC分类号： C07H21/04 ,  C07K14/00

    CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/523 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55538 ,  A61K2039/585 ,  C12N7/00 ,  C12N2710/20034 ,  C12N2740/16034 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16222 ,  C12N2740/16234 ,  C12N2740/16322 ,  C12N2740/16334 ,  C12N2760/16134 ,  C12N2770/24234

    摘要： Improved anti-HIV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus sequences for HIV Subtype A Envelope protein, those having consensus sequences for HIV Subtype B Envelope protein, those having consensus sequences for HIV Subtype C Envelope protein, those having consensus sequences for HIV Subtype D Envelope protein, those having consensus sequences for HIV Subtype B consensus Nef-Rev protein, and those having consensus sequences for HIV Gag protein subtypes A, B, C and D. Improved anti-HPV immunogens and nucleic acid molecules that encode them; improved anti-HCV immunogens and nucleic acid molecules that encode them; improved hTERT immunogens and nucleic acid molecules that encode them; and improved anti-Influenza immunogens and nucleic acid molecules that encode them are disclosed. Pharmaceutical composition, recombinant vaccines comprising and live attenuated pathogens are disclosed as well methods of inducing an immune response in an individual against HIV, HPV, HCV, hTERT and Influenza are disclosed.

    摘要翻译： 公开了改进的抗HIV免疫原和编码它们的核酸分子。 公开的免疫原包括具有HIV亚型A包膜蛋白的共有序列的那些，具有HIV亚型B包膜蛋白的共有序列的那些，对于HIV亚型C包膜蛋白具有共有序列的那些，对于HIV亚型D包膜蛋白具有共有序列的那些 HIV亚型B共有序列Nef-Rev蛋白，以及具有HIV Gag蛋白亚型A，B，C和D共有序列的序列。改进的编码它们的抗HPV免疫原和核酸分子; 改进的抗HCV免疫原和编码它们的核酸分子; 改进的hTERT免疫原和编码它们的核酸分子; 并公开了改进的抗流感免疫原和编码它们的核酸分子。 公开了包含和减毒病原体的重组疫苗的药物组合物，以及在个体中针对HIV，HPV，HCV，hTERT和流感诱导免疫应答的方法。

    Improved vaccines and methods for using the same
    8.
    发明公开
    Improved vaccines and methods for using the same 有权
    Verbesserte Impfstoffe gegen HIV

    公开(公告)号：EP2594576A1

    公开(公告)日：2013-05-22

    申请号：EP12197840.7

    申请日：2007-07-30

    申请人： The Trustees of The University of Pennsylvania

    发明人： Weiner, David. B ,  Yan, Jian ,  Laddy, Dominick,J.

    IPC分类号： C07H21/04 ,  C07K14/00

    CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/523 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55538 ,  A61K2039/585 ,  C12N7/00 ,  C12N2710/20034 ,  C12N2740/16034 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16222 ,  C12N2740/16234 ,  C12N2740/16322 ,  C12N2740/16334 ,  C12N2760/16134 ,  C12N2770/24234

    摘要： Improved anti-HIV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus sequences for HIV Subtype A Envelope protein, those having consensus sequences for HIV Subtype B Envelope protein, those having consensus sequences for HIV Subtype C Envelope protein, those having consensus sequences for HIV Subtype D Envelope protein, those having consensus sequences for HIV Subtype B consensus Nef-Rev protein, and those having consensus sequences for HIV Gag protein subtypes A, B, C and D. Improved anti-HPV immunogens and nucleic acid molecules that encode them; improved anti-HCV immunogens and nucleic acid molecules that encode them; improved hTERT immunogens and nucleic acid molecules that encode them; and improved anti-Influenza immunogens and nucleic acid molecules that encode them are disclosed. Pharmaceutical composition, recombinant vaccines comprising and live attenuated pathogens are disclosed as well methods of inducing an immune response in an individual against HIV, HPV, HCV, hTERT and Influenza are disclosed.

    摘要翻译： 公开了改进的抗HIV免疫原和编码它们的核酸分子。 公开的免疫原包括具有HIV亚型A包膜蛋白的共有序列的那些，具有HIV亚型B包膜蛋白的共有序列的那些，对于HIV亚型C包膜蛋白具有共有序列的那些，对于HIV亚型D包膜蛋白具有共有序列的那些 HIV亚型B共有序列Nef-Rev蛋白，以及具有HIV Gag蛋白亚型A，B，C和D共有序列的序列。改进的编码它们的抗HPV免疫原和核酸分子; 改进的抗HCV免疫原和编码它们的核酸分子; 改进的hTERT免疫原和编码它们的核酸分子; 并公开了改进的抗流感免疫原和编码它们的核酸分子。 公开了包含和减毒病原体的重组疫苗的药物组合物，以及在个体中针对HIV，HPV，HCV，hTERT和流感诱导免疫应答的方法。