公开(公告)号：EP1060394A2

公开(公告)日：2000-12-20

申请号：EP99904211.2

申请日：1999-01-21

申请人： Therasense, Inc.

发明人： SAY, James ,  TOMASCO, Michael, F. ,  HELLER, Adam ,  GAL, Yoram ,  ARIA, Behrad ,  HELLER, Ephraim ,  PLANTE, Phillip, J. ,  VREEKE, Mark, S.

IPC分类号： G01N33/487 ,  C12Q1/00

CPC分类号： A61B5/14532 ,  A61B5/01 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/14735 ,  A61B5/1486 ,  A61B5/14865 ,  C12Q1/001 ,  C12Q1/006

摘要： An electrochemical analyte sensor formed using conductive traces on a substrate can be used for determining and/or monitoring a level of analyte in in vitro or in vivo analyte-containing fluids. For example, an implantable sensor may be used for the continuous or automatic monitoring of a level of an analyte, such as glucose, lactate, or oxygen, in a patient. The electrochemical analyte sensor includes a substrate and conductive material disposed on the substrate, the conductive material forming a working electrode. In some sensors, the conductive material is disposed in recessed channels formed in a surface of the sensor. An electron transfer agent and/or catalyst may be provided to facilitate the electrolysis of the analyte or of a second compound whose level depends on the level of the analyte. A potential is formed between the working electrode and a reference electrode or counter/reference electrode and the resulting current is a function of the concentration of the analyte in the body fluid.

公开(公告)号：EP1060388A1

公开(公告)日：2000-12-20

申请号：EP99908338.9

申请日：1999-02-22

申请人： Therasense, Inc.

发明人： SAY, James ,  TOMASCO, Michael, F. ,  HELLER, Adam ,  GAL, Yoram ,  ARIA, Behrad ,  HELLER, Ephraim ,  PLANTE, Phillip, J. ,  VREEKE, Mark, S.

IPC分类号： G01N27/327 ,  C12Q1/00 ,  G01N33/543

CPC分类号： A61B5/14735 ,  A61B5/14532 ,  A61B5/14865 ,  A61B2562/0271 ,  A61B2562/125 ,  C12Q1/001 ,  G01N27/3272 ,  G01N33/5438 ,  G01N33/54393 ,  G01N33/66 ,  Y10T29/42 ,  Y10T29/49002 ,  Y10T29/49004 ,  Y10T29/49007 ,  Y10T29/49117 ,  Y10T29/49128 ,  Y10T29/49155 ,  Y10T29/49208 ,  Y10T29/49798 ,  Y10T156/1064 ,  Y10T156/1082

摘要： A process for the manufacture of small sensors with reproducible surfaces, including electrochemical sensors. One process includes forming channels in the surface of a substrate and disposing a conductive material in the channels to form an electrode. The conductive material can also be formed on the substrate by other impact and non-impact methods. In a preferred embodiment, the method includes the steps of providing a continuous substrate web, and disposing a pattern of a conductive material on the continuous substrate web to form one or more working electrodes and/or counter electrodes.

摘要翻译： 一种制造具有可重复表面的小型传感器的方法，包括电化学传感器。 一种方法包括在衬底的表面中形成通道并在通道中设置导电材料以形成电极。 导电材料也可以通过其他冲击和非冲击方法形成在基板上。 在一个优选实施例中，该方法包括以下步骤：提供连续的衬底腹板，以及将导电材料的图案设置在连续的衬底腹板上以形成一个或多个工作电极和/或对置电极。

公开(公告)号：EP1075209A1

公开(公告)日：2001-02-14

申请号：EP99903239.4

申请日：1999-01-21

申请人： Therasense, Inc.

发明人： SAY, James ,  TOMASCO, Michael, F. ,  HELLER, Adam ,  GAL, Yoram ,  ARIA, Behrad ,  HELLER, Ephraim ,  PLANTE, Phillip, J. ,  VREEKE, Mark, S. ,  FRIEDMAN, Keith A. ,  COLMAN, Fredric, C.

IPC分类号： A61B5/00

CPC分类号： A61B5/14865 ,  A61B5/0002 ,  A61B5/002 ,  A61B5/01 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/72 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/7405 ,  A61B5/743 ,  A61B5/7445 ,  A61B5/7455 ,  A61B2560/0252 ,  A61M5/1723 ,  C12Q1/54 ,  G06F19/00 ,  G06F19/34 ,  H01L23/3107 ,  H01L23/49548 ,  H01L2924/0002 ,  H01L2924/19041 ,  H01L2924/3011 ,  Y10S128/903 ,  Y10T29/49 ,  Y10T29/49124 ,  H01L2924/00

摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.