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1.发明公开
公开(公告)号：EP4144835A1
公开(公告)日：2023-03-08
申请号：EP21797636.4
申请日：2021-04-26
IPC分类号： C12N5/077 , A61K35/32 , A61L27/36 , A61L27/38 , A61L27/40 , A61L27/58 , A61P19/08 , A61P43/00
摘要： The present invention provides a means for efficiently preparing a cell population rich in functional chondrocytes that produce an extracellular matrix such as type II collagen. This culture method according to the present invention involves a method of culturing a cell population containing cartilage-derived cells positive for expression of Tie2 (cartilage-derived Tie2-positive cells), the method comprising culturing a cell population containing cartilage-derived Tie2-positive cells in a culture medium containing at least one kind of Tie2 expression enhancer other than growth factors (e.g., an extract derived from a plant of the genus Cinnamomum). This culturing method is preferably performed in cultureware having a culture surface coated with a coating agent (e.g., a polylysine-containing agent).
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公开(公告)号：EP3947643A1
公开(公告)日：2022-02-09
申请号：EP20707846.0
申请日：2020-02-06
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3.发明公开INTERVERTEBRAL DISC NUCLEUS PULPOSUS STEM/PROGENITOR CELL, METHOD FOR CULTURING SAME, AND APPLICATION 审中-公开BAND DISCS-髓核家长/及其使用PRE细胞培养和方法
公开(公告)号：EP2554660A1
公开(公告)日：2013-02-06
申请号：EP11762825.5
申请日：2011-03-29
IPC分类号： C12N5/077 , A61K35/28 , A61K38/00 , A61P19/00 , C12N5/0775
CPC分类号： C12N5/0654 , A61K35/12 , C12N5/0655 , C12N5/0668 , C12N2501/17 , C12N2502/1394 , C12N2502/99
摘要： The purpose of the present invention is to provide intervertebral disk nucleus pulposus stem cells or progenitor cells that may be used for treatment of intervertebral disk disorders. The present invention provides an intervertebral disk nucleus pulposus cell characterized by being isolated from the intervertebral disk nucleus pulposus of a vertebrate and being positive for at least one surface marker from among Tie2 and GD2. That is, the present invention provides an intervertebral disk nucleus pulposus stem cell characterized by being at least Tie2-positive for the surface marker and possessing self-renewal ability as well as multipotency capable of differentiating into adipocytes, osteocytes, chondrocytes and neurons. The present invention also provides an intervertebral disk nucleus pulposus progenitor cell characterized by being at least Tie2-negative and GD2-positive for the surface marker and capable of differentiating into any of adipocytes, osteocytes, chondrocytes and neurons.
摘要翻译： 本发明的目的是提供一种椎间盘髓核干细胞或祖细胞也可以用于治疗椎间盘病症。 本发明提供了由来自脊椎动物的椎间盘髓核中分离并从Tie2的和GD2中用于至少一个表面标记是正的特征的椎间盘髓核细胞。 即，本发明提供了对通过至少是Tie2的正面为表面标志物和特点波塞唱能够分化成脂肪细胞，骨细胞，软骨细胞和神经细胞的自我更新能力，以及多能椎间盘髓核干细胞。 本发明因此提供了关于通过至少是特征的椎间盘髓核祖细胞Tie2的负和GD2阳性的表面标记物和能分化成任何的脂肪细胞，骨细胞，软骨细胞和神经元。
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公开(公告)号：EP3997211A1
公开(公告)日：2022-05-18
申请号：EP21755088.8
申请日：2021-07-29
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