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    Renin-active substance comprising human prorerin and antibodies to the prorerin profragment
    2.
    发明公开
    Renin-active substance comprising human prorerin and antibodies to the prorerin profragment 有权
    Reninaktive Substanz enthaltend humanes Prorerin undAntikörpergegen das Prorerin Stragment

    公开(公告)号：EP0994187A1

    公开(公告)日：2000-04-19

    申请号：EP99308080.3

    申请日：1999-10-13

    申请人： Tokiwa Chemical Industries Co., Ltd. ,  Ishida, Yuichi

    发明人： Murakami, Kazuo ,  Nakamura, Yukio ,  Suzuki, Fumiaki ,  Ishida, Yuichi

    IPC分类号： C12N9/64 ,  C07K16/40

    CPC分类号： C12N9/6486 ,  A61K38/00 ,  A61K39/395 ,  C07K16/40 ,  C12Y304/23015 ,  A61K2300/00

    摘要： Disclosed is a novel renin-active substance by utilizing a anti-peptide antibody capable of specifically recognizing a specific amino acid sequence in the human prorenin profragment exemplified, as a typical example, by a complex formed from human prorenin and an anti-peptide antibody capable of specifically recognizing an amino acid sequence consisting of at least 15 amino acid residues located within an amino acid sequence consisting of 33 amino acid residues between the isoleucine residue at the 11th site and the arginine residue at the 43rd site within human prorenin profragment having an amino acid sequence consisting of 43 amino acid residues.

    摘要翻译： 公开了一种新型的肾素活性物质，其通过利用能够特异性识别人类肾上腺素毒性作用中的特定氨基酸序列的抗肽抗体，作为典型实例，通过由人类肾上腺素形成的复合物和抗肽抗体 特异性识别由位于第11个位点的异亮氨酸残基之间的33个氨基酸残基的氨基酸序列中的至少15个氨基酸残基组成的氨基酸序列和人类肾上腺素的碎片中的第43位的精氨酸残基， 酸序列由43个氨基酸残基组成。