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19 条记录 (耗时 0.016 秒)

    Renin-active substance comprising human prorerin and antibodies to the prorerin profragment
    3.
    发明公开
    Renin-active substance comprising human prorerin and antibodies to the prorerin profragment 有权
    Reninaktive Substanz enthaltend humanes Prorerin undAntikörpergegen das Prorerin Stragment

    公开(公告)号：EP0994187A1

    公开(公告)日：2000-04-19

    申请号：EP99308080.3

    申请日：1999-10-13

    申请人： Tokiwa Chemical Industries Co., Ltd. ,  Ishida, Yuichi

    发明人： Murakami, Kazuo ,  Nakamura, Yukio ,  Suzuki, Fumiaki ,  Ishida, Yuichi

    IPC分类号： C12N9/64 ,  C07K16/40

    CPC分类号： C12N9/6486 ,  A61K38/00 ,  A61K39/395 ,  C07K16/40 ,  C12Y304/23015 ,  A61K2300/00

    摘要： Disclosed is a novel renin-active substance by utilizing a anti-peptide antibody capable of specifically recognizing a specific amino acid sequence in the human prorenin profragment exemplified, as a typical example, by a complex formed from human prorenin and an anti-peptide antibody capable of specifically recognizing an amino acid sequence consisting of at least 15 amino acid residues located within an amino acid sequence consisting of 33 amino acid residues between the isoleucine residue at the 11th site and the arginine residue at the 43rd site within human prorenin profragment having an amino acid sequence consisting of 43 amino acid residues.

    摘要翻译： 公开了一种新型的肾素活性物质，其通过利用能够特异性识别人类肾上腺素毒性作用中的特定氨基酸序列的抗肽抗体，作为典型实例，通过由人类肾上腺素形成的复合物和抗肽抗体 特异性识别由位于第11个位点的异亮氨酸残基之间的33个氨基酸残基的氨基酸序列中的至少15个氨基酸残基组成的氨基酸序列和人类肾上腺素的碎片中的第43位的精氨酸残基， 酸序列由43个氨基酸残基组成。

    HUMAN METALLOTHIONEIN-II PROMOTER IN MAMMALIAN EXPRESSION SYSTEM
    6.
    发明授权
    HUMAN METALLOTHIONEIN-II PROMOTER IN MAMMALIAN EXPRESSION SYSTEM 失效
    人造金属表达系统中的人METALOTHIONEIN-II促进剂

    公开(公告)号：EP0217822B1

    公开(公告)日：1993-05-12

    申请号：EP86901613.9

    申请日：1986-02-11

    申请人： SCIOS NOVA INC.

    发明人： KUSHNER, Peter, J. ,  COFER, Claire, L. ,  FRIEDMAN, Jeffrey, S. ,  TALMADGE, Karen, D.

    IPC分类号： C12N5/00 ,  C07K13/00 ,  C07K15/08

    CPC分类号： C12N9/6486 ,  C07K14/505 ,  C07K14/58 ,  C07K14/61 ,  C07K14/775 ,  C07K14/785 ,  C12N15/85 ,  C12Y304/23015

    摘要： An expression system for recombinant production of a desired protein comprises CHO cells transformed with a DNA sequence having the desired protein coding sequence under control of the human metallothionein-II promoter. The cells can be maintained on serum-free medium and induced in the presence of an induction mediator. In addition, the system may include an enhancer element and/or a resistance-conferring gene to provide increased levels of expression. The system can process genomic as well as intronless DNA, and is capable of producing proteins which have the same characteristics as those obtained from native sources. Human growth hormone which is indistinguishable from that produced by the pituitary has been thus produced. Expression systems containing genes encoding alveolar surfactant protein (ASH), apolipoproteins AI and AII (apoAI and apoAII), atrial natriuretic factor (ANF), erythropoetin (Epo), and renin are also contemplated.

    Recombinant human renin
    8.
    发明公开
    Recombinant human renin 失效
    重组人肾素。

    公开(公告)号：EP0196921A2

    公开(公告)日：1986-10-08

    申请号：EP86302432.9

    申请日：1986-04-02

    申请人： CALIFORNIA BIOTECHNOLOGY INC.(a Delaware corporation)

    发明人： Fritz, Lawrence C.

    IPC分类号： C12N15/00 ,  C12N9/64 ,  C12N1/20 ,  C12N5/00 ,  C07K5/00 ,  C07K7/00

    CPC分类号： C12N9/6486 ,  A61K38/00 ,  C12N1/38 ,  C12Y304/23015

    摘要： Expression vectors and methods for effecting the production of recombinant renin, prorenin, and preprorenin are disclosed. Sufficient quantities are thus obtained to generate pharmaceuticals useful in the treatment of disorders mediated by excessive renin levels such as hypertension. Methods to purify renin and prorenin from cell supernatants and to increase mature renin secretion are also disclosed.

    摘要翻译： 公开了用于实现重组肾素，肾上腺素和前列腺素生产的表达载体和方法。 因此获得足够的量以产生可用于治疗由过量肾素水平如高血压介导的病症的药物。 还公开了从细胞上清液中纯化肾素和肾上腺素并增加成熟肾素分泌的方法。

    HYPOTENSORS
    9.
    发明公开
    HYPOTENSORS 审中-公开
    HYPOTENSOREN

    公开(公告)号：EP1273914A1

    公开(公告)日：2003-01-08

    申请号：EP01919831.6

    申请日：2001-04-09

    申请人： Ishida, Yuichi

    发明人： Ishida, Yuichi, 8-205, West Heights ,  Suzuki, Fumiaki ,  Murakami, Kazuo

    IPC分类号： G01N33/50 ,  G01N33/15 ,  C07K5/08 ,  C07K5/10 ,  C07K7/06 ,  C07K7/08 ,  A61P9/12 ,  A61K38/04

    CPC分类号： C12N9/6486 ,  A61K38/00 ,  C07K14/4705 ,  C12Q1/37 ,  C12Y304/23015 ,  G01N2333/96472 ,  G01N2500/00

    摘要： There are provided a method for selection of a substance which is capable of controlling activation of prorenin where an adjusting ability of the activation of prorenin by protein-protein interaction in a profragment region of prorenin as indicator is used; a prorenin activation controlling substance having a function of controlling the activation of prorenin based on protein-protein interaction by a profragment region of prorenin; and hypotensor, organ hypertrophy suppressor and arterial thickening suppressor containing the said prorenin activation controlling substance as an effective ingredient.

    摘要翻译： 提供了选择能够控制肾上腺素激活的物质的方法，其中使用在作为指示剂的肾上腺素的碎片区域中通过蛋白质 - 蛋白质相互作用来激活肾上腺素的调节能力; 具有根据蛋白质 - 蛋白质相互作用的蛋白质 - 蛋白质相互作用控制肾上腺素的活化的功能的肾上腺素能激活控制物质; 低血压素，器官肥大抑制剂和动脉增厚抑制剂，其含有所述血管内皮素激活控制物质作为有效成分。