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    Renin-active substance comprising human prorerin and antibodies to the prorerin profragment
    3.
    发明公开
    Renin-active substance comprising human prorerin and antibodies to the prorerin profragment 有权
    Reninaktive Substanz enthaltend humanes Prorerin undAntikörpergegen das Prorerin Stragment

    公开(公告)号：EP0994187A1

    公开(公告)日：2000-04-19

    申请号：EP99308080.3

    申请日：1999-10-13

    申请人： Tokiwa Chemical Industries Co., Ltd. ,  Ishida, Yuichi

    发明人： Murakami, Kazuo ,  Nakamura, Yukio ,  Suzuki, Fumiaki ,  Ishida, Yuichi

    IPC分类号： C12N9/64 ,  C07K16/40

    CPC分类号： C12N9/6486 ,  A61K38/00 ,  A61K39/395 ,  C07K16/40 ,  C12Y304/23015 ,  A61K2300/00

    摘要： Disclosed is a novel renin-active substance by utilizing a anti-peptide antibody capable of specifically recognizing a specific amino acid sequence in the human prorenin profragment exemplified, as a typical example, by a complex formed from human prorenin and an anti-peptide antibody capable of specifically recognizing an amino acid sequence consisting of at least 15 amino acid residues located within an amino acid sequence consisting of 33 amino acid residues between the isoleucine residue at the 11th site and the arginine residue at the 43rd site within human prorenin profragment having an amino acid sequence consisting of 43 amino acid residues.

    摘要翻译： 公开了一种新型的肾素活性物质，其通过利用能够特异性识别人类肾上腺素毒性作用中的特定氨基酸序列的抗肽抗体，作为典型实例，通过由人类肾上腺素形成的复合物和抗肽抗体 特异性识别由位于第11个位点的异亮氨酸残基之间的33个氨基酸残基的氨基酸序列中的至少15个氨基酸残基组成的氨基酸序列和人类肾上腺素的碎片中的第43位的精氨酸残基， 酸序列由43个氨基酸残基组成。

    HYPOTENSORS
    5.
    发明公开
    HYPOTENSORS 审中-公开
    HYPOTENSOREN

    公开(公告)号：EP1273914A1

    公开(公告)日：2003-01-08

    申请号：EP01919831.6

    申请日：2001-04-09

    申请人： Ishida, Yuichi

    发明人： Ishida, Yuichi, 8-205, West Heights ,  Suzuki, Fumiaki ,  Murakami, Kazuo

    IPC分类号： G01N33/50 ,  G01N33/15 ,  C07K5/08 ,  C07K5/10 ,  C07K7/06 ,  C07K7/08 ,  A61P9/12 ,  A61K38/04

    CPC分类号： C12N9/6486 ,  A61K38/00 ,  C07K14/4705 ,  C12Q1/37 ,  C12Y304/23015 ,  G01N2333/96472 ,  G01N2500/00

    摘要： There are provided a method for selection of a substance which is capable of controlling activation of prorenin where an adjusting ability of the activation of prorenin by protein-protein interaction in a profragment region of prorenin as indicator is used; a prorenin activation controlling substance having a function of controlling the activation of prorenin based on protein-protein interaction by a profragment region of prorenin; and hypotensor, organ hypertrophy suppressor and arterial thickening suppressor containing the said prorenin activation controlling substance as an effective ingredient.

    摘要翻译： 提供了选择能够控制肾上腺素激活的物质的方法，其中使用在作为指示剂的肾上腺素的碎片区域中通过蛋白质 - 蛋白质相互作用来激活肾上腺素的调节能力; 具有根据蛋白质 - 蛋白质相互作用的蛋白质 - 蛋白质相互作用控制肾上腺素的活化的功能的肾上腺素能激活控制物质; 低血压素，器官肥大抑制剂和动脉增厚抑制剂，其含有所述血管内皮素激活控制物质作为有效成分。