公开(公告)号：EP2967379A1

公开(公告)日：2016-01-20

申请号：EP14765096.4

申请日：2014-03-14

申请人： The Regents of the University of California ,  Topera, Inc.

发明人： NARAYAN, Sanjiv ,  BRIGGS, Carey, Robert ,  SEHRA, Ruchir

IPC分类号： A61B5/0245

CPC分类号： A61B5/02405 ,  A61B5/0006 ,  A61B5/02444 ,  A61B5/04012 ,  A61B5/0422 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/6852 ,  A61B2560/0475 ,  A61B2562/04

摘要： A system and method of identifying a driver of a source associated with a heart rhythm disorder are disclosed. Data is accessed from a plurality of sensors representing biological activity in the heart. A local first region of the heart that has repeating activation and that controls a second distant region of the heart for at least a predetermined number of beats is identified. The first local region is assigned as a driver of a source of the heart rhythm disorder, the source including the first local region and the second distant region.

摘要翻译： 公开了一种识别与心律紊乱相关的源的驾驶员的系统和方法。 从代表心脏中生物活性的多个传感器访问数据。 识别具有重复激活并且控制心脏的第二远距离区域达至少预定次数的心跳的心脏的局部第一区域。 第一局部区域被指定为心律紊乱源的驱动器，该源包括第一局部区域和第二远区域。

公开(公告)号：EP3451912A1

公开(公告)日：2019-03-13

申请号：EP17793183.9

申请日：2017-05-02

申请人： The Regents of the University of California ,  Topera, Inc.

发明人： NARAYAN, Sanjiv ,  BRIGGS, Carey Robert ,  SEHRA, Ruchir

IPC分类号： A61B5/02

公开(公告)号：EP2787879A1

公开(公告)日：2014-10-15

申请号：EP12855266.8

申请日：2012-12-08

申请人： The Regents of the University of California ,  Topera, Inc.

发明人： NARAYAN, Sanjiv ,  BRIGGS, Carey Robert

IPC分类号： A61B5/0452 ,  A61B5/0464 ,  A61B5/042

CPC分类号： A61B5/0468 ,  A61B5/002 ,  A61B5/02405 ,  A61B5/04011 ,  A61B5/04012 ,  A61B5/042 ,  A61B5/0422 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/04525 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/7239 ,  A61B5/7246 ,  A61B5/7257 ,  A61B5/7425 ,  A61B5/743 ,  A61B8/02

摘要： An example system and method of locating a source of a heart rhythm disorder are disclosed. In accordance with the method, a first pair of cardiac signals is processed to define a first coefficient associated with variability of the first pair of signals at a first region of the heart. Further, a second pair of cardiac signals is processed to define a second coefficient associated with variability of the second pair of signals at a second region of the heart. Thereafter, the first coefficient of variability is compared to the second coefficient of variability to determine a direction towards the source of the rhythm disorder.

摘要翻译： 公开了一种定位心律失常源的示例系统和方法。 根据该方法，处理第一对心脏信号以定义与心脏的第一区域处的第一对信号的变化性相关联的第一系数。 此外，处理第二对心脏信号以定义与心脏的第二区域处的第二对信号的变化性相关联的第二系数。 此后，将第一变异系数与第二变异系数进行比较以确定朝向节律紊乱源的方向。

公开(公告)号：EP3125756A1

公开(公告)日：2017-02-08

申请号：EP15774130.7

申请日：2015-04-01

申请人： The Regents of the University of California ,  Topera, Inc.

发明人： NARAYAN, Sanjiv ,  BRIGGS, Carey Robert ,  SEHRA, Ruchir

IPC分类号： A61B5/024

CPC分类号： A61B5/6852 ,  A61B5/04011 ,  A61B5/0422 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/7264 ,  A61B2505/05

摘要： A system and method for identifying and treating a source of a heart rhythm disorder are provided in which a spatial element associated with a region of the heart is selected. Progressive rotational activations or progressive focal activations are determined in relation to the selected spatial element. A plurality of indexes of progressive rotational activations or progressive focal activations over time is formed. One or more indexes are selected from the plurality of indexes that indicate consistency of the successive rotational activations or the progressive focal activations in relation to a portion of the region of the heart.

摘要翻译： 本发明提供一种用于鉴定和治疗心脏节律紊乱的源系统和方法，其中与所述心脏的一个区域相关联的空间元件被选择。 渐进旋转激活或渐进焦激活是确定性的开采相对于所选择的空间元素。 渐进旋转激活或随时间渐进焦激活的索引的多个形成。 一个或多个索引，从索引的多个所选择的并指示心脏的区域的一部分相对于所述连续旋转激活或渐进焦激活的一致性。

公开(公告)号：EP2705464A1

公开(公告)日：2014-03-12

申请号：EP12779506.0

申请日：2012-05-02

申请人： Topera, Inc. ,  The Regents Of The University Of California

发明人： NARAYAN, Sanjiv ,  BRIGGS, Carey, Robert

IPC分类号： G06K9/00

CPC分类号： A61B5/04012 ,  A61B5/042 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/4029 ,  A61B5/4064 ,  A61B5/4839 ,  A61B18/1492 ,  A61B2018/00357 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61M5/00 ,  A61N1/0565 ,  G06F19/00

摘要： A system and method to target a biological rhythm disorder include processing cardiac signals via a computing device to determine a shape in a region of tissue defined by a source associated with the biological rhythm disorder that migrates spatially on or within the shape, and identifying at least one portion of the tissue proximate to the shape to enable selective modification of the at least one portion of tissue in order to terminate or alter the biological rhythm disorder.

公开(公告)号：EP2705464B1

公开(公告)日：2018-04-18

申请号：EP12779506.0

申请日：2012-05-02

申请人： Topera, Inc. ,  The Regents of the University of California

发明人： NARAYAN, Sanjiv ,  BRIGGS, Carey, Robert

IPC分类号： G06K9/00

CPC分类号： A61B5/04012 ,  A61B5/042 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/4029 ,  A61B5/4064 ,  A61B5/4839 ,  A61B18/1492 ,  A61B2018/00357 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61M5/00 ,  A61N1/0565 ,  G06F19/00

摘要： A system and method to target a biological rhythm disorder include processing cardiac signals via a computing device to determine a shape in a region of tissue defined by a source associated with the biological rhythm disorder that migrates spatially on or within the shape, and identifying at least one portion of the tissue proximate to the shape to enable selective modification of the at least one portion of tissue in order to terminate or alter the biological rhythm disorder.

公开(公告)号：EP2533687B1

公开(公告)日：2016-07-27

申请号：EP12711553.3

申请日：2012-03-21

申请人： Topera, Inc. ,  The Regents of the University of California

发明人： BRIGGS, Carey Robert ,  NARAYAN, Sanjiv

IPC分类号： A61B5/024 ,  A61B5/0255 ,  A61B5/00 ,  A61B5/042 ,  A61B5/0452 ,  A61B5/0205 ,  A61B5/04 ,  A61B5/046 ,  A61B5/0464

CPC分类号： A61B5/02405 ,  A61B5/0002 ,  A61B5/0205 ,  A61B5/0255 ,  A61B5/04011 ,  A61B5/04012 ,  A61B5/0422 ,  A61B5/0452 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/4836 ,  A61B5/6852 ,  A61B5/7203 ,  A61B5/7217 ,  A61B5/7239 ,  A61B5/7246 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/742 ,  A61B5/743 ,  A61B18/02 ,  A61B18/12 ,  A61B18/18 ,  A61B2018/00577 ,  A61B2562/046

公开(公告)号：EP2967399A2

公开(公告)日：2016-01-20

申请号：EP14763969.4

申请日：2014-03-14

申请人： The Regents of the University of California ,  Topera, Inc.

发明人： NARAYAN, Sanjiv ,  BRIGGS, Carey Robert ,  SEHRA, Ruchir

IPC分类号： A61B5/0452

CPC分类号： A61B5/04012 ,  A61B5/0205 ,  A61B5/02405 ,  A61B5/0255 ,  A61B5/04011 ,  A61B5/0422 ,  A61B5/0452 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/7203 ,  A61B5/7217 ,  A61B5/7239 ,  A61B5/7246 ,  A61B5/7278 ,  A61B5/742 ,  A61B2562/046

摘要： An example system and method of reconstructing cardiac activation information are disclosed. An analysis signal and a reference signal are processed to determine whether there is a first point of change in a first selected-order derivative of the analysis signal with respect to a first selected-order derivative of the reference signal above a first threshold. The analysis signal and the reference signal are processed to determine whether there is a second point of change in a second selected-order derivative of the analysis cardiac signal above a second threshold. An activation onset time is assigned in the analysis cardiac signal at a point based on a mathematical association of the first point of change and the second point of change to define cardiac activation indicating a beat in the analysis cardiac signal.

公开(公告)号：EP3330894A1

公开(公告)日：2018-06-06

申请号：EP18150721.1

申请日：2012-05-02

申请人： Topera, Inc. ,  The Regents of The University of California Santa Cruz

发明人： NARAYAN, Sanjiv ,  BRIGGS, Carey Robert

IPC分类号： G06K9/00

CPC分类号： A61B5/04012 ,  A61B5/042 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/4029 ,  A61B5/4064 ,  A61B5/4839 ,  A61B18/1492 ,  A61B2018/00357 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61M5/00 ,  A61N1/0565 ,  G06F19/00

摘要： Provided is a system and method to target a biological rhythm disorder, such as a heart rhythm disorder. The system and method include processing cardiac signals via a computing device to determine a shape in a region of tissue defined by a source associated with the biological rhythm disorder that migrates spatially on or within the shape, and identifying at least one portion of the tissue proximate to the shape to enable selective modification of the at least one portion of tissue in order to terminate or alter the heart rhythm disorder.

公开(公告)号：EP2787880A1

公开(公告)日：2014-10-15

申请号：EP12855738.6

申请日：2012-12-08

申请人： The Regents of the University of California ,  Topera, Inc.

发明人： BRIGGS, Carey Robert ,  NARAYAN, Sanjiv

IPC分类号： A61B5/0452 ,  A61B5/0464 ,  A61B5/042

CPC分类号： A61B5/0468 ,  A61B5/002 ,  A61B5/02405 ,  A61B5/04011 ,  A61B5/04012 ,  A61B5/042 ,  A61B5/0422 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/04525 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/7239 ,  A61B5/7246 ,  A61B5/7257 ,  A61B5/7425 ,  A61B5/743 ,  A61B8/02

摘要： An example system and method of determining regularity associated with a rhythm disorder of a heart are disclosed. In accordance with the method, a derivative of a first cardiac signal at a plurality of first time points is processed against a derivative of a second cardiac signal at a plurality of second time points to define a plurality of coordinate pairs of the first cardiac signal against the second cardial signal. Thereafter, an index of regularity that exceeds a threshold is determined. The index of regularity indicates an approximate congruence of the plurality of coordinate pairs among the first cardiac signal and the second cardiac signal.