公开(公告)号：EP3196183B1

公开(公告)日：2019-05-01

申请号：EP15841268.4

申请日：2015-09-07

申请人： Toray Fine Chemicals Co., Ltd.

发明人： NAKATANI, Jiro ,  NOZOE, Tatsuhiro

IPC分类号： C07C45/42 ,  C07C45/45 ,  C07C49/80

公开(公告)号：EP3196183A1

公开(公告)日：2017-07-26

申请号：EP15841268.4

申请日：2015-09-07

申请人： Toray Fine Chemicals Co., Ltd.

发明人： NAKATANI, Jiro ,  NOZOE, Tatsuhiro

IPC分类号： C07C45/42 ,  C07C49/80

CPC分类号： C07C45/42 ,  C07C45/455 ,  C07C49/80

摘要： The present invention is a method of producing a 2'-trifluoromethyl-substituted aromatic ketone comprising reacting a 2-halogen-substituted benzotrifluoride compound with magnesium metal to convert the compound to a Grignard reagent; and reacting the Grignard reagent with an acid anhydride; and then hydrolyzing the resultant to produce a 2'-trifluoromethyl-substituted aromatic ketone. The method of producing a 2'-trifluoromethyl-substituted aromatic ketone of the present invention enables 2'-trifluoromethyl-substituted aromatic ketone to be produced without using expensive raw materials by generating a Grignard reagent as an intermediate and reacting this Grignard reagent with an acid anhydride in an efficient productivity. The 2'-trifluoromethyl-substituted aromatic ketone that is produced by the method of producing a 2'-trifluoromethyl-substituted aromatic ketone of the present invention can be used as fine chemicals, raw materials for pharmaceuticals and agrochemicals, raw materials for resins and plastics, electronics and information related materials, optical materials, and the like.

摘要翻译： 本发明是一种制备2'-三氟甲基取代的芳族酮的方法，该方法包括使2-卤素取代的三氟甲苯化合物与镁金属反应以将该化合物转化成格利雅试剂; 并使格氏试剂与酸酐反应; 然后水解生成物以产生2'-三氟甲基取代的芳族酮。 生产本发明的2'-三氟甲基取代的芳族酮的方法使得能够在不使用昂贵的原料的情况下通过生成格利雅试剂作为中间体来生产2'-三氟甲基取代的芳族酮并且使该格利雅试剂与酸 酸酐以有效的生产率生产。 通过本发明的2'-三氟甲基取代的芳香族酮的制造方法制造的2'-三氟甲基取代芳香族酮可以作为精细化学品，药品和农药的原料，树脂和塑料的原料 ，电子和信息相关材料，光学材料等。