公开(公告)号：EP3881926A1

公开(公告)日：2021-09-22

申请号：EP20747621.9

申请日：2020-01-17

Applicant: Toray Industries, Inc.

Inventor： USHIRO, Suguru ,  HAYASHI, Akihiro ,  SAKAGUCHI, Hirokazu

IPC: B01D63/02 ,  B01D69/02 ,  B01D69/08 ,  B01D71/26 ,  B01D71/28 ,  B01D71/30 ,  B01D71/34 ,  B01D71/38 ,  B01D71/40 ,  B01D71/42 ,  B01D71/44 ,  B01D71/48 ,  B01D71/50 ,  B01D71/52 ,  B01D71/54 ,  B01D71/56 ,  B01D71/68 ,  D01F1/08 ,  A61M1/18

Abstract: A separation membrane module includes a case and a separation membrane built in the case, wherein the separation membrane module satisfies the following requirements (1) to (3): (1) the separation membrane contains a hydrophobic polymer, a hydrophilic polymer, and a biocompatible copolymer, the hydrophilic polymer containing a hydrophilic polymer having mobility, (2) the separation membrane contains the hydrophilic polymer having mobility in a range of 1.0 to 1.7% by mass, and (3) a water content per self-weight of the separation membrane is in a range of 0 to 10% by mass. The separation membrane module is provided in which fouling of a membrane is suppressed and the amount of eluted substance is small.

公开(公告)号：EP3495004A1

公开(公告)日：2019-06-12

申请号：EP17836877.5

申请日：2017-07-28

Applicant: Toray Industries, Inc.

Inventor： USHIRO, Suguru ,  HAYASHI, Akihiro ,  UENO, Yoshiyuki

IPC: A61M1/16 ,  A61L33/00 ,  B01D69/12

Abstract: The purpose of the present invention is to provide a biological component adhesion-suppressing material that is able to suppress adhesion of platelets and proteins even when coming into contact with blood, etc. The present invention comprises a substrate which is provided with a functional layer having, fixed on a surface thereof that comes into contact with a biological component, a polymer including a saturated aliphatic monocarboxylic acid vinyl ester unit, wherein: when compositional analysis is performed on the surface of the functional layer using a TOF-SIMS device, the number of carbon atoms in an aliphatic chain representing an ion signal detected for saturated aliphatic carboxylic acid is 2-20; and an XPS measurement taken of the surface of the functional layer shows a peak derived from an ester group.

公开(公告)号：EP3141296A1

公开(公告)日：2017-03-15

申请号：EP15789788.5

申请日：2015-05-07

Applicant: Toray Industries, Inc.

Inventor： HAYASHI, Akihiro ,  UENO, Yoshiyuki

IPC: B01D71/68 ,  A61M1/18 ,  B01D63/02 ,  B01D65/02 ,  B01D69/02 ,  B01D69/08 ,  B01D71/38 ,  B01D71/40 ,  B01D71/44 ,  B01D71/52

CPC classification number: B01D71/68 ,  B01D63/02 ,  B01D63/021 ,  B01D65/02 ,  B01D69/02 ,  B01D69/08 ,  B01D71/38 ,  B01D71/40 ,  B01D71/44 ,  B01D71/52 ,  B01D2325/36

Abstract: Disclosed is a hollow fiber membrane module including a case and a hollow fiber membrane built in the case, wherein the hollow fiber membrane contains a polysulfone-based polymer and a hydrophilic polymer, and satisfies the following (A) and (B), and an amount of an eluted substance contained in a liquid obtained by circulating ultrapure water heated at 37°C through a passage of an inner surface side of the hollow fiber membrane for 4 hours at 200 mL/min is 1.0 mg/m 2 or less:
(A) an insoluble component accounts for less than 3% by mass of the total mass of the hollow fiber membrane when the hollow fiber membrane is dissolved in N,N-dimethylacetamide; and
(B) a flexible layer exists on a surface of a functional layer in a wet state and the flexible layer has a thickness of 7 nm or more. The present invention provides a hollow fiber membrane module including a hollow fiber membrane containing a polysulfone-based polymer and a hydrophilic polymer built therein, which elutes little eluted substance and exhibits high biocompatibility, while change in performance due to crosslinking of the hydrophilic polymer is suppressed.

Abstract translation: 公开了一种中空纤维膜组件，其包括壳体和内置于其中的中空纤维膜，其中中空纤维膜含有聚砜系聚合物和亲水性高分子，满足下述（A）和（B）， 将通过使中空纤维膜的内表面侧通过中空纤维膜的内表面侧以200mL / min通过4小时而使在37℃下加热的超纯水循环而得到的液体中所含的洗脱物的量为1.0mg / m 2以下：（ A）中空纤维膜溶解在N，N-二甲基乙酰胺中时，不溶成分占中空纤维膜总质量的3质量％以下; 和（B）在湿态的功能层的表面上存在柔性层，柔性层的厚度为7nm以上。 本发明提供一种中空纤维膜组件，其包括含有聚砜系聚合物和内置亲水性聚合物的中空纤维膜，其中洗脱少量洗脱物质并表现出高生物相容性，同时由于亲水性聚合物的交联而导致的性能变化被抑制 。

公开(公告)号：EP3845573A1

公开(公告)日：2021-07-07

申请号：EP21155811.9

申请日：2017-09-20

Applicant: Toray Industries, Inc.

Inventor： USHIRO, Suguru ,  HAYASHI, Akihiro ,  UENO, Yoshiyuki

IPC: C08F226/02 ,  A61L33/06 ,  C08F226/10

Abstract: The purpose of the present invention is to provide: a copolymer that is capable of being immobilized on a base material while maintaining a high antithrombotic property persistently without having to introduce heparin or an anticoagulant drug to the surface thereof; and a medical material using same. Provided is a copolymer that comprises monomer unit A, monomer unit B, and monomer unit C represented in in chemical formula 1, wherein monomer unit C has a mole fraction of 0.5-40% with respect to the total amount of all constituent monomer units.

公开(公告)号：EP4316646A1

公开(公告)日：2024-02-07

申请号：EP22775391.0

申请日：2022-03-17

Applicant: Toray Industries, Inc.

Inventor： SAKAGUCHI, Yuka ,  HAYASHI, Akihiro ,  HAN, Aishan ,  SAKAGUCHI, Hirokazu

IPC: B01J20/26 ,  B01J20/28 ,  G01N27/62

Abstract: An object of the present invention is to provide a porous adsorption material that is to be used for adsorbing and removing an impurity from a solution containing a raw biopharmaceutical compound while suppressing clogging and is high in separation selectivity, and the present invention provides a porous adsorption material that is to be used for adsorbing and removing an impurity from a solution containing a raw biopharmaceutical compound and includes a layer containing a nonionic polymer on at least one surface of the porous adsorption material.

公开(公告)号：EP3508232A1

公开(公告)日：2019-07-10

申请号：EP17846214.9

申请日：2017-08-22

Applicant: Toray Industries, Inc.

Inventor： USHIRO, Suguru ,  HAYASHI, Akihiro ,  UENO, Yoshiyuki

IPC: A61M1/18 ,  A61L33/06

Abstract: The purpose of the present invention is to provide a medical material capable of suppressing adhesion of platelets and proteins even when in contact with biological components such as blood for an extended period of time. The present invention provides a medical material that is a copolymer comprising hydrophobic units and hydrophilic units in which the hydrophobic units have a C2-20 terminal alkyl group in a side chain, the static contact angle of water in the copolymer is at least 30° and less than 70°, and the glass transition temperature of the copolymer exists at only one point in the range from 45°C to less than 90°C.

公开(公告)号：EP3053614A1

公开(公告)日：2016-08-10

申请号：EP14848452.0

申请日：2014-09-26

Applicant: Toray Industries, Inc.

Inventor： HAYASHI, Akihiro ,  NOSAKA, Shiro ,  UENO, Yoshiyuki

IPC: A61M1/18 ,  B01D63/02 ,  B01D69/00 ,  B01D69/08 ,  B01D71/68

CPC classification number: B01D67/0013 ,  A61M1/16 ,  B01D63/02 ,  B01D67/0016 ,  B01D69/02 ,  B01D69/08 ,  B01D71/58 ,  B01D71/68 ,  B01D2323/02 ,  B01D2325/02 ,  B01D2325/36

Abstract: The purpose of the present invention is to provide a porous membrane that has both high water permeability and excellent protein fractionation performance. Provided is a method for producing a porous membrane, said method comprising a step for discharging a membrane-forming dope that contains a hydrophilic polymer from a slit formed in a mouthpiece, and a step for, after the passage of the discharged membrane-forming dope through a dry part, solidifying the membrane-forming dope in a coagulation bath to give a porous membrane, wherein the cross-section area of the slit is 3-30 times inclusive as large as the cross-section area of the solidified porous membrane.

公开(公告)号：EP4063006A1

公开(公告)日：2022-09-28

申请号：EP20889553.2

申请日：2020-11-19

Applicant: Toray Industries, Inc.

Inventor： AKAIKE, Kaori ,  HAYASHI, Akihiro ,  SAKAGUCHI, Hirokazu

IPC: B01D69/02 ,  B01D71/38 ,  B01D71/44 ,  B01D71/68 ,  G01N27/62

Abstract: The present invention aims to provide a porous separation membrane that does not suffer a significant decrease in the protein permeability even after long term use. The porous separation membrane has an asymmetric structure with a dense layer forming one surface layer and with a coarse layer forming the other surface layer, supports a biocompatible polymer, and meet the requirements (1) and (2) given below in surface analysis of a cross section containing the dense layer and the coarse layer performed by TOF-SIMS:
(1) the minimum value of normalized intensity of the ion signal attributed to the biocompatible polymer in the coarse layer is 0.15 times or more of the maximum value, and
(2) the normalized average intensity of the ion signal attributed to the biocompatible polymer in the dense layer is 2.0 times or more of the normalized average intensity of the ion signal attributed to carboxylic acid in the coarse layer.

公开(公告)号：EP3766567A1

公开(公告)日：2021-01-20

申请号：EP19806556.7

申请日：2019-05-24

Applicant: Toray Industries, Inc.

Inventor： HAYASHI, Akihiro ,  AKAIKE, Kaori ,  USHIRO, Suguru ,  UENO, Yoshiyuki

IPC: B01D69/08 ,  B01D69/00 ,  B01D71/40 ,  B01D71/68 ,  C08J9/26 ,  C08J9/42

Abstract: Disclosed is a porous hollow fiber membrane containing a polysulfone-based polymer as a main component, which has an asymmetric structure in which the inner surface side is dense and the outer surface side is coarse, wherein an average of a minor axis diameter of pores of an inner surface is 20 nm or more and 40 nm or less, an open porosity of the inner surface is 10% or more and 30% or less, and a polymer including a monocarboxylic acid vinyl ester unit is supported on at least one of the outer surface and the inner surface. The present invention provides a hollow fiber membrane which has excellent removing performance of substances to be separated such as viruses, and can be used as a separation membrane having high permeability even in a treatment under low pressure.

公开(公告)号：EP3521328A1

公开(公告)日：2019-08-07

申请号：EP17855871.4

申请日：2017-09-20

Applicant: Toray Industries, Inc.

Inventor： USHIRO, Suguru ,  HAYASHI, Akihiro ,  UENO, Yoshiyuki

IPC: C08F226/00 ,  A61L33/06

Abstract: The purpose of the present invention is to provide: a copolymer that is capable of being immobilized on a base material while maintaining a high antithrombotic property persistently without having to introduce heparin or an anticoagulant drug to the surface thereof; and a medical material using same. Provided is a copolymer that comprises monomer unit A, monomer unit B, and monomer unit C represented in in chemical formula 1, wherein monomer unit C has a mole fraction of 0.5-40% with respect to the total amount of all constituent monomer units.