HOLLOW FIBER MEMBRANE MODULE AND MANUFACTURING METHOD THEREOF
    8.
    发明公开
    HOLLOW FIBER MEMBRANE MODULE AND MANUFACTURING METHOD THEREOF 审中-公开
    HOHLFASERMEMBRANMODUL UND HERSTELLUNGSVERFAHRENDAFÜR

    公开(公告)号:EP3141296A1

    公开(公告)日:2017-03-15

    申请号:EP15789788.5

    申请日:2015-05-07

    Abstract: Disclosed is a hollow fiber membrane module including a case and a hollow fiber membrane built in the case, wherein the hollow fiber membrane contains a polysulfone-based polymer and a hydrophilic polymer, and satisfies the following (A) and (B), and an amount of an eluted substance contained in a liquid obtained by circulating ultrapure water heated at 37°C through a passage of an inner surface side of the hollow fiber membrane for 4 hours at 200 mL/min is 1.0 mg/m 2 or less:
    (A) an insoluble component accounts for less than 3% by mass of the total mass of the hollow fiber membrane when the hollow fiber membrane is dissolved in N,N-dimethylacetamide; and
    (B) a flexible layer exists on a surface of a functional layer in a wet state and the flexible layer has a thickness of 7 nm or more. The present invention provides a hollow fiber membrane module including a hollow fiber membrane containing a polysulfone-based polymer and a hydrophilic polymer built therein, which elutes little eluted substance and exhibits high biocompatibility, while change in performance due to crosslinking of the hydrophilic polymer is suppressed.

    Abstract translation: 公开了一种中空纤维膜组件,其包括壳体和内置于其中的中空纤维膜,其中中空纤维膜含有聚砜系聚合物和亲水性高分子,满足下述(A)和(B), 将通过使中空纤维膜的内表面侧通过中空纤维膜的内表面侧以200mL / min通过4小时而使在37℃下加热的超纯水循环而得到的液体中所含的洗脱物的量为1.0mg / m 2以下:( A)中空纤维膜溶解在N,N-二甲基乙酰胺中时,不溶成分占中空纤维膜总质量的3质量%以下; 和(B)在湿态的功能层的表面上存在柔性层,柔性层的厚度为7nm以上。 本发明提供一种中空纤维膜组件,其包括含有聚砜系聚合物和内置亲水性聚合物的中空纤维膜,其中洗脱少量洗脱物质并表现出高生物相容性,同时由于亲水性聚合物的交联而导致的性能变化被抑制 。

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