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公开(公告)号：EP4317409A1
公开(公告)日：2024-02-07
申请号：EP22780271.7
申请日：2022-03-18
发明人： SAWABATA, Noriyoshi , MORITA, Kohei , OBAYASHI, Chiho , SAKAGUCHI, Hirokazu , TOMINAGA, Yoshiaki , ARAKANE, Toru , MORIOKA, Satoko , NODA, Yohei
IPC分类号： C12M3/04 , B01D39/00 , C12M3/06 , C12N5/071 , C12N5/0775 , C12N5/078 , C12N5/0789 , C12N5/09 , C12N5/095 , C12Q1/02 , G01N1/04
摘要： A filter having a plurality of filter pores penetrating one surface and the other surface of the filter, in which the filter pore has a first opening on the one surface and a second opening on the other surface, a ratio of a major axis diameter L1 to a minor axis diameter W1 of the first opening is 1.00 or more and 1.20 or less, the minor axis diameter W1 is 7.0 µm or more and 9.0 µm or less, a ratio of a major axis diameter L2 to a minor axis diameter W2 of the second opening is 1.00 or more and 1.20 or less, and a ratio of the minor axis diameter W2 to the minor axis diameter W 1 and a ratio of the major axis diameter L2 to the major axis diameter L1 are both 1.20 or more and 1.50 or less.
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公开(公告)号：EP4316646A1
公开(公告)日：2024-02-07
申请号：EP22775391.0
申请日：2022-03-17
摘要： An object of the present invention is to provide a porous adsorption material that is to be used for adsorbing and removing an impurity from a solution containing a raw biopharmaceutical compound while suppressing clogging and is high in separation selectivity, and the present invention provides a porous adsorption material that is to be used for adsorbing and removing an impurity from a solution containing a raw biopharmaceutical compound and includes a layer containing a nonionic polymer on at least one surface of the porous adsorption material.
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3.发明授权
公开(公告)号：EP2518100B1
公开(公告)日：2015-02-18
申请号：EP10839438.8
申请日：2010-12-22
IPC分类号： C08G81/00 , A61L33/00 , C08F8/34 , C08F16/06 , C08F18/08 , C08F26/10 , C08G77/392 , C08G77/46 , C08G83/00 , C08G85/00
CPC分类号： C08G85/004 , A61L33/0011 , A61L2400/18
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4.发明公开HYDROPHILIC POLYMER COMPOUND HAVING ANTICOAGULATION EFFECT 有权水溶性聚合物麻醉剂GERINNUNGSVERHINDERNDER WIRKUNG
公开(公告)号：EP2518100A1
公开(公告)日：2012-10-31
申请号：EP10839438.8
申请日：2010-12-22
IPC分类号： C08G81/00 , A61L33/00 , C08F8/34 , C08F16/06 , C08F18/08 , C08F26/10 , C08G77/392 , C08G77/46 , C08G83/00 , C08G85/00
CPC分类号： C08G85/004 , A61L33/0011 , A61L2400/18
摘要： An object of the present invention is to provide a hydrophilic polymer compound which can inhibit both of the blood coagulation reactions in the primary hemostasis stage in which platelets are involved and in the coagulation thrombus formation stage in which blood coagulation factors are involved, which hydrophilic polymer compound can be firmly immobilized on the surface of medical devices or medical materials, in the state retaining the anticoagulant activity. The present invention provides a hydrophilic polymer compound comprising a polymer compound which inhibits platelet adhesion, and a compound that inhibits blood coagulation reaction, bound to said polymer compound.
摘要翻译： 本发明的目的是提供一种亲水性高分子化合物，该亲水性高分子化合物可抑制血小板参与的初级止血阶段的血液凝固反应和涉及凝血因子的凝血性血栓形成阶段， 化合物可以在保持抗凝血活性的状态下牢固地固定在医疗装置或医疗材料的表面上。 本发明提供了包含抑制血小板粘附的聚合物化合物和与所述高分子化合物结合的抑制血液凝固反应的化合物的亲水性高分子化合物。
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公开(公告)号：EP2072070A1
公开(公告)日：2009-06-24
申请号：EP07807191.7
申请日：2007-09-13
CPC分类号： A61K47/34 , A61K31/40 , A61L31/16 , A61L33/0011 , A61L2300/42 , A61M1/3672 , A61M1/3673
摘要： The present invention relates to a substrate including a compound having blood anticoagulation activity and a hydrophilic polymer compound, wherein the amount of elution of the compound having blood anticoagulation activity is less than 0.6 µg/ml, and a manufacturing method of a substrate, wherein after a compound having blood anticoagulation activity and a hydrophilic compound brought in contact with a substrate are irradiated with radiation, unreacted components are washed out.
摘要翻译： 本发明涉及包含具有血液抗凝血活性的化合物和亲水性高分子化合物的底物，其中具有血液抗凝血活性的化合物的洗脱量低于0.6μg/ ml，和底物的制备方法，其中在 用辐射照射具有血液抗凝血活性的化合物和与基质接触的亲水性化合物，洗掉未反应的组分。
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公开(公告)号：EP4063006A1
公开(公告)日：2022-09-28
申请号：EP20889553.2
申请日：2020-11-19
摘要： The present invention aims to provide a porous separation membrane that does not suffer a significant decrease in the protein permeability even after long term use. The porous separation membrane has an asymmetric structure with a dense layer forming one surface layer and with a coarse layer forming the other surface layer, supports a biocompatible polymer, and meet the requirements (1) and (2) given below in surface analysis of a cross section containing the dense layer and the coarse layer performed by TOF-SIMS:
(1) the minimum value of normalized intensity of the ion signal attributed to the biocompatible polymer in the coarse layer is 0.15 times or more of the maximum value, and
(2) the normalized average intensity of the ion signal attributed to the biocompatible polymer in the dense layer is 2.0 times or more of the normalized average intensity of the ion signal attributed to carboxylic acid in the coarse layer.-
公开(公告)号：EP4026573A1
公开(公告)日：2022-07-13
申请号：EP20874844.2
申请日：2020-10-07
IPC分类号： A61M1/16
摘要： An object of the present invention is to provide a purification column which is a small purification column in which a volume of a liquid to be treated is reduced in order to reduce the amount of blood to be taken out and which realizes a low pressure loss and has high adsorption performance. The present invention provides a fiber bundle including a plurality of porous fibers that satisfies the following requirements (A) to (E):
(A) the porous fiber has a non-hollow shape,
(B) an arithmetic average roughness (dry Ra value) of a surface of the porous fiber in a dry state is 11 nm or more and 30 nm or less,
(C) an arithmetic average roughness (wet Ra value) of a surface of the porous fiber in a wet state is 12 nm or more and 40 nm or less,
(D) a value represented by wet Ra/dry Ra is 1.05 or more, and
(E) a linear rate of the fiber bundle represented by (length of fiber bundle)/(length of one porous fiber) is 0.97 or more and 1.00 or less.-
8.发明公开
公开(公告)号：EP3520883A1
公开(公告)日：2019-08-07
申请号：EP17856026.4
申请日：2017-09-25
摘要： An object of the present invention is to provide a hollow fiber membrane module which makes it possible to concentrate incubated platelets by efficiently removing water from an incubated platelet suspension liquid containing incubated platelets while suppressing deterioration of the function of the incubated platelets. The present invention provides an incubated platelet concentration module in which a plurality of hollow fiber membranes each having pores with an average pore diameter of 2 µm or less on a surface of the hollow fiber membrane are packed in a casing having at least one inlet for supplying an incubated platelet suspension liquid before concentration into the hollow fiber membranes, wherein a value (X/Y1) obtained by dividing a total cross-sectional area (X) of the plurality of hollow fiber membranes by a total cross-sectional area (Y1) of the least one inlet is 4.0 or less.
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公开(公告)号：EP2072070B1
公开(公告)日：2016-11-09
申请号：EP07807191.7
申请日：2007-09-13
CPC分类号： A61K47/34 , A61K31/40 , A61L31/16 , A61L33/0011 , A61L2300/42 , A61M1/3672 , A61M1/3673
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公开(公告)号：EP4119587A1
公开(公告)日：2023-01-18
申请号：EP21768658.3
申请日：2021-03-12
IPC分类号： C08F218/02 , C09D183/04 , C09D183/07 , A61L33/06
摘要： The present invention aims to provide a coating agent that can be applied to various materials without using radiation, and a medical material using the same. The present invention provides a coating agent containing a copolymer that contains: a monomer unit (unit A) containing a Si-O bond; a vinyl carboxylate monomer unit (unit B); and a monomer unit (unit C) containing a hydrophilic group.
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