公开(公告)号：EP1539785A2

公开(公告)日：2005-06-15

申请号：EP03762172.9

申请日：2003-06-26

申请人： Transgenrx, Inc. ,  The Board of Supervisors of Louisiana State University and Agriculturaland Mechanical College

发明人： COOPER, Richard K. ,  CADD, Gary G. ,  FIORETTI, William C. ,  DEBOER, Kenneth F.

IPC分类号： C07H21/00

CPC分类号： A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2227/30 ,  A01K2267/01 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/62 ,  C07K16/00 ,  C07K16/02 ,  C07K16/1063 ,  C07K16/26 ,  C07K2317/23 ,  C07K2317/34 ,  C12N15/85 ,  C12N15/8509 ,  C12N2800/90 ,  C12N2830/008 ,  C12N2830/90 ,  C12N2840/20

摘要： Administration of modified transposon-based vectors has been used to achieve stable incorporation of exogenous genes into animals. These transgenic animals produce transgenic progeny. Further, these transgenic animals produce large quantities of desired molecules encoded by the transgene. Transgenic egg-laying animals produce large quantities of desired molecules encoded by the transgene and deposit these molecules in the egg.

公开(公告)号：EP1539785B1

公开(公告)日：2009-05-06

申请号：EP03762172.9

申请日：2003-06-26

申请人： Transgenrx, Inc. ,  THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE

发明人： COOPER, Richard K. ,  CADD, Gary G. ,  FIORETTI, William C. ,  DEBOER, Kenneth F.

IPC分类号： C07H21/00 ,  C12N15/00

CPC分类号： A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2227/30 ,  A01K2267/01 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/62 ,  C07K16/00 ,  C07K16/02 ,  C07K16/1063 ,  C07K16/26 ,  C07K2317/23 ,  C07K2317/34 ,  C12N15/85 ,  C12N15/8509 ,  C12N2800/90 ,  C12N2830/008 ,  C12N2830/90 ,  C12N2840/20

摘要： Administration of modified transposon-based vectors has been used to achieve stable incorporation of exogenous genes into animals. These transgenic animals produce transgenic progeny. Further, these transgenic animals produce large quantities of desired molecules encoded by the transgene. Transgenic egg-laying animals produce large quantities of desired molecules encoded by the transgene and deposit these molecules in the egg.

公开(公告)号：EP2417263A1

公开(公告)日：2012-02-15

申请号：EP10715625.9

申请日：2010-04-09

申请人： THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE ,  TransGenRx, Inc.

发明人： COOPER, Richard, K. ,  FIORETTI, William C.

IPC分类号： C12N15/85

CPC分类号： C12N15/8509 ,  A01K2267/01 ,  C12N9/22 ,  C12N2800/90 ,  C12N2830/40 ,  C12N2830/46

摘要： Novel compositions for the
in vitro or
in vivo production of specific proteins are provided. The compositions comprise components of vectors, such as a vector backbone, a promoter, and a gene of interest that encodes for the protein of interest, and the transposon-based vectors comprising these components. Also provided are methods of making these compositions and methods of using these compositions for the production of desired proteins in vivo or in transfected cells
in vitro .