公开(公告)号：EP1539785B1

公开(公告)日：2009-05-06

申请号：EP03762172.9

申请日：2003-06-26

申请人： Transgenrx, Inc. ,  THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE

发明人： COOPER, Richard K. ,  CADD, Gary G. ,  FIORETTI, William C. ,  DEBOER, Kenneth F.

IPC分类号： C07H21/00 ,  C12N15/00

CPC分类号： A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2227/30 ,  A01K2267/01 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/62 ,  C07K16/00 ,  C07K16/02 ,  C07K16/1063 ,  C07K16/26 ,  C07K2317/23 ,  C07K2317/34 ,  C12N15/85 ,  C12N15/8509 ,  C12N2800/90 ,  C12N2830/008 ,  C12N2830/90 ,  C12N2840/20

摘要： Administration of modified transposon-based vectors has been used to achieve stable incorporation of exogenous genes into animals. These transgenic animals produce transgenic progeny. Further, these transgenic animals produce large quantities of desired molecules encoded by the transgene. Transgenic egg-laying animals produce large quantities of desired molecules encoded by the transgene and deposit these molecules in the egg.

公开(公告)号：EP1592789B1

公开(公告)日：2009-05-20

申请号：EP03800225.9

申请日：2003-12-24

申请人： TransGenRx, Inc. ,  THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE

发明人： COOPER, Richard, K. ,  FIORETTI, William, C. ,  CADD, Gary G.

IPC分类号： C12N15/00 ,  C12N15/63 ,  C12P21/00 ,  A01K67/027

CPC分类号： C12N15/8509 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2227/30 ,  A01K2267/01 ,  A23L15/00 ,  A23V2002/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/62 ,  C07K16/00 ,  C07K16/02 ,  C07K16/1063 ,  C07K16/26 ,  C07K2317/23 ,  C07K2317/34 ,  C12N15/85 ,  C12N2800/90 ,  C12N2830/003 ,  C12N2830/008 ,  C12N2830/90 ,  C12N2840/20 ,  Y02A50/407 ,  Y02A50/469 ,  A23V2300/21

摘要： Administration of modified transposon-based vectors has been used to achieve stable incorporation of exogenous genes into animals. These transgenic animals produce transgenic progeny. Further, these transgenic animals produce large quantities of desired molecules encoded by the transgene. Transgenic egg-laying animals produce large quantities of desired molecules encoded by the transgene and deposit these molecules in the egg.

公开(公告)号：EP1592789A4

公开(公告)日：2006-09-13

申请号：EP03800225

申请日：2003-12-24

申请人： TRANSGENRX INC ,  UNIV LOUISIANA STATE

发明人： COOPER RICHARD K ,  FIORETTI WILLIAM C ,  CADD GARY G

IPC分类号： A01K67/027 ,  A23L15/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/62 ,  C07K16/00 ,  C07K16/02 ,  C07K16/10 ,  C07K16/26 ,  C12N15/85 ,  C12N15/00 ,  C12N15/63 ,  C12P21/00

CPC分类号： C12N15/8509 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2227/30 ,  A01K2267/01 ,  A23L15/00 ,  A23V2002/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/62 ,  C07K16/00 ,  C07K16/02 ,  C07K16/1063 ,  C07K16/26 ,  C07K2317/23 ,  C07K2317/34 ,  C12N15/85 ,  C12N2800/90 ,  C12N2830/003 ,  C12N2830/008 ,  C12N2830/90 ,  C12N2840/20 ,  A23V2300/21

摘要： Administration of modified transposon-based vectors has been used to achieve stable incorporation of exogenous genes into animals. These transgenic animals produce transgenic progeny. Further, these transgenic animals produce large quantities of desired molecules encoded by the transgene. Transgenic egg-laying animals produce large quantities of desired molecules encoded by the transgene and deposit these molecules in the egg.

公开(公告)号：EP1592789A2

公开(公告)日：2005-11-09

申请号：EP03800225.9

申请日：2003-12-24

申请人： Transgenrx, Inc. ,  THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE

发明人： COOPER, Richard, K. ,  FIORETTI, William, C. ,  CADD, Gary G.

IPC分类号： C12N15/00 ,  C12N15/63 ,  C12P21/00 ,  A01K67/027

CPC分类号： C12N15/8509 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2227/30 ,  A01K2267/01 ,  A23L15/00 ,  A23V2002/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/62 ,  C07K16/00 ,  C07K16/02 ,  C07K16/1063 ,  C07K16/26 ,  C07K2317/23 ,  C07K2317/34 ,  C12N15/85 ,  C12N2800/90 ,  C12N2830/003 ,  C12N2830/008 ,  C12N2830/90 ,  C12N2840/20 ,  Y02A50/407 ,  Y02A50/469 ,  A23V2300/21

摘要： Administration of modified transposon-based vectors has been used to achieve stable incorporation of exogenous genes into animals. These transgenic animals produce transgenic progeny. Further, these transgenic animals produce large quantities of desired molecules encoded by the transgene. Transgenic egg-laying animals produce large quantities of desired molecules encoded by the transgene and deposit these molecules in the egg.

公开(公告)号：EP2342224A2

公开(公告)日：2011-07-13

申请号：EP09815462.8

申请日：2009-09-25

申请人： TransGenRx, Inc. ,  THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE

发明人： FIORETTI, William, C. ,  COOPER, Richard, K.

IPC分类号： C07K14/555 ,  C12N15/63 ,  C07H21/04 ,  C12P21/06

CPC分类号： C07K14/555 ,  A01K2217/052 ,  A01K2227/30 ,  A01K2267/01 ,  C07K14/465 ,  C07K2319/43 ,  C07K2319/50 ,  C12N15/85 ,  C12N15/8509 ,  C12N2800/90 ,  C12N2830/15 ,  C12N2830/40 ,  C12N2830/46 ,  C12N2830/60 ,  C12N2830/90 ,  C12N2840/105

摘要： Novel compositions for the production of interferons such as interferon-α 2a, interferon-α 2b, or interferon-β 1a (IFN-α 2a, IFN-α 2b, or IFN-β 1a) are provided. The compositions comprise components of vectors, such as a vector backbone, a promoter, and a gene of interest that encodes an interferon such as IFN-α 2a, IFN-α 2b, or IFN-β 1a, and the vectors comprising these components. In certain embodiments, these vectors are transposon-based vectors. Also provided are methods of making these compositions and methods of using these compositions for the production of an interferon such as IFN-α 2a, IFN-α 2b, or IFN-β 1a.

公开(公告)号：EP1597378A2

公开(公告)日：2005-11-23

申请号：EP03808563.5

申请日：2003-12-24

申请人： Transgenrx, Inc. ,  THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE

发明人： COOPER, Richard, K. ,  FIORETTI, William, C. ,  CADD, Gary, G.

IPC分类号： C12P21/00 ,  A01K67/027 ,  A01K67/033 ,  C07H21/04 ,  C12N15/00

CPC分类号： C12N15/8509 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2227/30 ,  A01K2267/01 ,  A23L15/00 ,  A23V2002/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/62 ,  C07K16/00 ,  C07K16/02 ,  C07K16/1063 ,  C07K16/26 ,  C07K2317/23 ,  C07K2317/34 ,  C12N15/85 ,  C12N2800/90 ,  C12N2830/003 ,  C12N2830/008 ,  C12N2830/90 ,  C12N2840/20 ,  Y02A50/407 ,  Y02A50/469 ,  A23V2300/21

摘要： Administration of modified transposon-based vectors has been used to achieve stable incorporation of exogenous genes into animals. These transgenic animals produce transgenic progeny. Further, these transgenic animals produce large quantities of desired molecules encoded by the transgene. Transgenic egg-laying animals produce large quantities of desired molecules encoded by the transgene and deposit these molecules in the egg.

摘要翻译： 本发明提供了一种在个体中产生多聚体蛋白质的新的，有效的和有效的方法。 多聚体蛋白质包括相关的多聚体蛋白质（两种或更多种相关多肽）和多价多聚体蛋白质（由多于一种目的基因编码的单一多肽）。 个体中多聚蛋白的表达和/或形成是通过将含有编码部分多聚蛋白的感兴趣基因的多核苷酸盒给予个体来实现的。 多核苷酸盒可另外含有一个或多个pro序列，prepro序列，cecropin前原序列和/或切割位点序列。

公开(公告)号：EP1539785A2

公开(公告)日：2005-06-15

申请号：EP03762172.9

申请日：2003-06-26

申请人： Transgenrx, Inc. ,  The Board of Supervisors of Louisiana State University and Agriculturaland Mechanical College

发明人： COOPER, Richard K. ,  CADD, Gary G. ,  FIORETTI, William C. ,  DEBOER, Kenneth F.

IPC分类号： C07H21/00

CPC分类号： A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2227/30 ,  A01K2267/01 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/62 ,  C07K16/00 ,  C07K16/02 ,  C07K16/1063 ,  C07K16/26 ,  C07K2317/23 ,  C07K2317/34 ,  C12N15/85 ,  C12N15/8509 ,  C12N2800/90 ,  C12N2830/008 ,  C12N2830/90 ,  C12N2840/20

摘要： Administration of modified transposon-based vectors has been used to achieve stable incorporation of exogenous genes into animals. These transgenic animals produce transgenic progeny. Further, these transgenic animals produce large quantities of desired molecules encoded by the transgene. Transgenic egg-laying animals produce large quantities of desired molecules encoded by the transgene and deposit these molecules in the egg.

公开(公告)号：EP2417263A1

公开(公告)日：2012-02-15

申请号：EP10715625.9

申请日：2010-04-09

申请人： THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE ,  TransGenRx, Inc.

发明人： COOPER, Richard, K. ,  FIORETTI, William C.

IPC分类号： C12N15/85

CPC分类号： C12N15/8509 ,  A01K2267/01 ,  C12N9/22 ,  C12N2800/90 ,  C12N2830/40 ,  C12N2830/46

摘要： Novel compositions for the
in vitro or
in vivo production of specific proteins are provided. The compositions comprise components of vectors, such as a vector backbone, a promoter, and a gene of interest that encodes for the protein of interest, and the transposon-based vectors comprising these components. Also provided are methods of making these compositions and methods of using these compositions for the production of desired proteins in vivo or in transfected cells
in vitro .

公开(公告)号：EP1597378A4

公开(公告)日：2007-05-09

申请号：EP03808563

申请日：2003-12-24

申请人： TRANSGENRX INC ,  UNIV LOUISIANA STATE

发明人： COOPER RICHARD K ,  FIORETTI WILLIAM C ,  CADD GARY G

IPC分类号： A01K67/027 ,  A23L15/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/62 ,  C07K16/00 ,  C07K16/02 ,  C07K16/10 ,  C07K16/26 ,  C12N15/85 ,  C12P21/00 ,  A01K67/033 ,  C07H21/04 ,  C12N15/00

CPC分类号： C12N15/8509 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2227/30 ,  A01K2267/01 ,  A23L15/00 ,  A23V2002/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/62 ,  C07K16/00 ,  C07K16/02 ,  C07K16/1063 ,  C07K16/26 ,  C07K2317/23 ,  C07K2317/34 ,  C12N15/85 ,  C12N2800/90 ,  C12N2830/003 ,  C12N2830/008 ,  C12N2830/90 ,  C12N2840/20 ,  A23V2300/21

摘要： Administration of modified transposon-based vectors has been used to achieve stable incorporation of exogenous genes into animals. These transgenic animals produce transgenic progeny. Further, these transgenic animals produce large quantities of desired molecules encoded by the transgene. Transgenic egg-laying animals produce large quantities of desired molecules encoded by the transgene and deposit these molecules in the egg.

公开(公告)号：EP1539785A4

公开(公告)日：2006-03-29

申请号：EP03762172

申请日：2003-06-26

申请人： TRANSGENRX INC ,  UNIV LOUISIANA STATE

发明人： COOPER RICHARD K ,  CADD GARY G ,  FIORETTI WILLIAM C ,  DEBOER KENNETH F

IPC分类号： A01K67/027 ,  A61K39/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/62 ,  C07K16/00 ,  C07K16/02 ,  C07K16/10 ,  C07K16/18 ,  C07K16/26 ,  C12N5/10 ,  C12N15/09 ,  C12N15/85 ,  C07H21/00 ,  C12N15/00

CPC分类号： A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2227/30 ,  A01K2267/01 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/62 ,  C07K16/00 ,  C07K16/02 ,  C07K16/1063 ,  C07K16/26 ,  C07K2317/23 ,  C07K2317/34 ,  C12N15/85 ,  C12N15/8509 ,  C12N2800/90 ,  C12N2830/008 ,  C12N2830/90 ,  C12N2840/20