公开(公告)号：EP3677118A1

公开(公告)日：2020-07-08

申请号：EP19204566.4

申请日：2007-04-19

申请人： Transmedics, Inc.

发明人： KYI, Stanley ,  HAVNER, Robert ,  HASSANEIN, Waleed ,  KHAYAL, Tamer ,  SALEH, Hesham ,  FATTAH, Ihab Abdel ,  TRACHTENBERG, Jon

IPC分类号： A01N1/02 ,  A61M11/00 ,  A61M11/04 ,  A61M16/00 ,  A61M16/10 ,  G01N33/49

摘要： Claims relate to an organ care system for maintaining an ex vivo lung in a near physiologic functioning condition comprising:
a perfusion circuit for flowing fluid into and out of the ex vivo lung; a composition for use in the perfusion circuit to maintain the ex vivo lung in the near physiologic functioning condition, the composition comprising one or more carbohydrates that include dextran, and a plurality of amino acids that do not include asparagine, glutamine, or cysteine; and
a nutritional subsystem comprising an infusion pump.

公开(公告)号：EP2244773A2

公开(公告)日：2010-11-03

申请号：EP09707471.0

申请日：2009-01-30

申请人： Transmedics, Inc.

发明人： FISHMAN, Robert ,  HAVENER, Robert ,  FATTAH, Ihab Abdel ,  ABDELAZIM, Anas ,  NEWELL, Scott ,  BISHOP, Tom ,  KHAYAL, Tamer ,  KYI, Stanley ,  TAYLOR, Ronald ,  HARRIOTT, Doug ,  DE REMER, Matthew ,  MURRAY, Paul ,  SULLIVAN, John ,  ANDERSON, Mark ,  BRINGHAM, Richard ,  VAN DRIEL, Michael ,  HASSANEIN, Waleed

IPC分类号： A61M16/00

CPC分类号： A01N1/021 ,  A01N1/02 ,  A01N1/0247

摘要： Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

公开(公告)号：EP4331362A3

公开(公告)日：2024-05-01

申请号：EP23209551.3

申请日：2009-01-30

申请人： TransMedics, Inc.

发明人： FISHMAN, Robert ,  HAVENER, Robert ,  FATTAH, Ihab Abdel ,  ABDELAZIM, Anas ,  NEWELL, Scott ,  BISHOP, Tom ,  KHAYAL, Tamer ,  KYI, Stanley ,  TAYLOR, Ronald ,  HARRIOTT, Doug ,  DE REMER, Matthew ,  MURRAY, Paul ,  SULLIVAN, John ,  ANDERSON, Mark ,  BRINGHAM, Richard ,  VAN DRIEL, Michael ,  HASSANEIN, Waleed

IPC分类号： A01N1/02

CPC分类号： A01N1/0247 ,  A01N1/02 ,  A01N1/021

摘要： Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

公开(公告)号：EP4331362A2

公开(公告)日：2024-03-06

申请号：EP23209551.3

申请日：2009-01-30

申请人： TransMedics, Inc.

发明人： FISHMAN, Robert ,  HAVENER, Robert ,  FATTAH, Ihab Abdel ,  ABDELAZIM, Anas ,  NEWELL, Scott ,  BISHOP, Tom ,  KHAYAL, Tamer ,  KYI, Stanley ,  TAYLOR, Ronald ,  HARRIOTT, Doug ,  DE REMER, Matthew ,  MURRAY, Paul ,  SULLIVAN, John ,  ANDERSON, Mark ,  BRINGHAM, Richard ,  VAN DRIEL, Michael ,  HASSANEIN, Waleed

IPC分类号： A01N1/02

摘要： Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.