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    DEVICE FOR HEART VALVE REPLACEMENT
    1.
    发明公开
    DEVICE FOR HEART VALVE REPLACEMENT 审中-公开

    公开(公告)号：EP4252714A3

    公开(公告)日：2023-12-20

    申请号：EP23192834.2

    申请日：2012-10-19

    申请人： Twelve, Inc.

    发明人： MORRISS, John ,  GIFFORD, Hanson ,  FANN, James L. ,  DUERI, Jean-Pierre ,  GITTINGS, Darrin ,  LUNA, Michael ,  DEEM, Mark ,  SUTTON, Douglas

    IPC分类号： A61F2/24

    摘要： A prosthetic heart valve device (100) for percutaneous replacement of a native heart valve includes an expandable retainer (110) at least partially surrounding and coupled to an inner valve support (120). The device can further include a prosthetic valve (130) coupled to the valve support. The retainer forms a donut-shaped flange (190) having an arcuate outer surface (142) for engaging tissue and an inner lumen defining a passage for blood to flow through the valve support. The retainer can include a plurality of circumferentially positioned, resiliency deformable and flexible ribs (114) which are coupled at their downstream ends 116 to the valve support 120. The flexible ribs, in one embodiment, can have a general C-shape configuration with the tips (117) of the flexible ribs and an opening (119) of the C-shape configuration oriented toward a longitudinal axis (101) of the device.

    DEVICE FOR HEART VALVE REPLACEMENT
    3.
    发明公开
    DEVICE FOR HEART VALVE REPLACEMENT 审中-公开

    公开(公告)号：EP4252714A2

    公开(公告)日：2023-10-04

    申请号：EP23192834.2

    申请日：2012-10-19

    申请人： Twelve, Inc.

    发明人： MORRISS, John ,  GIFFORD, Hanson ,  FANN, James L. ,  DUERI, Jean-Pierre ,  GITTINGS, Darrin ,  LUNA, Michael ,  DEEM, Mark ,  SUTTON, Douglas

    IPC分类号： A61F2/24

    摘要： A prosthetic heart valve device (100) for percutaneous replacement of a native heart valve includes an expandable retainer (110) at least partially surrounding and coupled to an inner valve support (120). The device can further include a prosthetic valve (130) coupled to the valve support. The retainer forms a donut-shaped flange (190) having an arcuate outer surface (142) for engaging tissue and an inner lumen defining a passage for blood to flow through the valve support. The retainer can include a plurality of circumferentially positioned, resiliency deformable and flexible ribs (114) which are coupled at their downstream ends 116 to the valve support 120. The flexible ribs, in one embodiment, can have a general C-shape configuration with the tips (117) of the flexible ribs and an opening (119) of the C-shape configuration oriented toward a longitudinal axis (101) of the device.

    PROSTHETIC HEART VALVE DEVICES
    4.
    发明公开
    PROSTHETIC HEART VALVE DEVICES 审中-公开

    公开(公告)号：EP3984500A1

    公开(公告)日：2022-04-20

    申请号：EP21212528.0

    申请日：2012-10-19

    申请人： Twelve, Inc.

    发明人： MORRISS, John ,  GIFFORD, Hanson, III ,  FANN, James, L. ,  DUERI, Jean-Pierre ,  MCLEAN, Matt ,  GITTINGS, Darrin ,  LUNA, Michael ,  DEEM, Mark ,  SUTTON, Douglas ,  GRAINGER, Jeffrey, J.

    IPC分类号： A61F2/24

    摘要： A prosthetic heart valve (100) includes a flexible anchoring member (110) at least partially surrounding and coupled to an inner valve support (120). The device can further include a prosthetic valve (130) coupled to, mounted within, or otherwise carried by the valve support. The valve support includes a plurality of posts (122) connected circumferentially by a plurality of struts (124), where the posts extend along an axial direction generally parallel to the longitudinal axis (101) and the struts extend circumferentially around and transverse to the longitudinal axis. The posts extend an entire longitudinal height HI of the valve support 120. The device also includes one or more sealing members (140) and tissue engaging elements (170) like spikes.

    DEVICES, SYSTEMS AND METHODS FOR HEART VALVE REPLACEMENT
    6.
    发明公开
    DEVICES, SYSTEMS AND METHODS FOR HEART VALVE REPLACEMENT 审中-公开
    VORRICHTUNGEN，SYSTEME UND VERFAHRENFÜRDEN ERSATZ EINER HERZKLAPPE

    公开(公告)号：EP2750630A1

    公开(公告)日：2014-07-09

    申请号：EP12784809.1

    申请日：2012-10-19

    申请人： Twelve, Inc.

    发明人： MORRISS, John ,  GIFFORD, Hanson ,  FANN, James, L. ,  DUERI, Jean-Pierre ,  GITTINGS, Darrin ,  LUNA, Michael ,  DEEM, Mark ,  SUTTON, Douglas

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2436 ,  A61F2210/0076 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/0025 ,  A61F2220/0041 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/006

    摘要： Prosthetic heart valve devices for percutaneous replacement of native heart valves and associated systems and method are disclosed herein. A prosthetic heart valve device configured in accordance with a particular embodiment of the present technology can include a valve support having an upstream end and a downstream end extending around a longitudinal axis and having a cross-sectional shape. The valve support can have an outer surface and an inner surface, wherein the inner surface is configured to support a prosthetic valve. The device can also include an expandable retainer coupled to the upstream end of the valve support. The retainer can be configured to engage tissue on or near the annulus. In some embodiments, the valve support is mechanically isolated from the retainer such that the cross-sectional shape of the valve support remains sufficiently stable when the retainer is deformed in a non-circular shape by engagement with the tissue.

    摘要翻译： 用于经皮更换天然心脏瓣膜的假体心脏瓣膜装置（100）包括至少部分地围绕并联接到内部阀支撑件（120）的可膨胀保持器（110）。 该装置还可包括联接到阀支撑件的人造瓣膜（130）。 保持器形成具有用于接合组织的弓形外表面（142）的环形凸缘（190）和限定血液通过阀支撑件的通道的内腔。 保持器可以包括多个周向定位的弹性变形和柔性肋（114），其在其下游端116处联接到阀支撑件120.在一个实施例中，柔性肋可以具有一般的C形构造，其中 柔性肋的尖端（117）和朝向装置的纵向轴线（101）定向的C形构造的开口（119）。

    DEVICE FOR HEART VALVE REPLACEMENT
    8.
    发明公开
    DEVICE FOR HEART VALVE REPLACEMENT 审中-公开

    公开(公告)号：EP3943047A1

    公开(公告)日：2022-01-26

    申请号：EP21181385.2

    申请日：2012-10-19

    申请人： Twelve, Inc.

    发明人： MORRISS, John ,  GIFFORD, Hanson ,  FANN, James L. ,  DUERI, Jean-Pierre ,  GITTINGS, Darrin ,  LUNA, Michael ,  DEEM, Mark ,  SUTTON, Douglas

    IPC分类号： A61F2/24

    摘要： A prosthetic heart valve device (100) for percutaneous replacement of a native heart valve includes an expandable retainer (110) at least partially surrounding and coupled to an inner valve support (120). The device can further include a prosthetic valve (130) coupled to the valve support. The retainer forms a donut-shaped flange (190) having an arcuate outer surface (142) for engaging tissue and an inner lumen defining a passage for blood to flow through the valve support. The retainer can include a plurality of circumferentially positioned, resiliency deformable and flexible ribs (114) which are coupled at their downstream ends 116 to the valve support 120. The flexible ribs, in one embodiment, can have a general C-shape configuration with the tips (117) of the flexible ribs and an opening (119) of the C-shape configuration oriented toward a longitudinal axis (101) of the device.