公开(公告)号：EP2940013A4

公开(公告)日：2016-08-03

申请号：EP13868493

申请日：2013-12-27

申请人： UBE INDUSTRIES

发明人： IWASE NORIAKI ,  NISHIDA HIROSHI ,  OKUDO MAKOTO ,  ITO MASAAKI ,  KONO SHIGEYUKI ,  MATOYAMA MASAAKI ,  USHIYAMA SHIGERU ,  OKANARI EIJI ,  MATSUNAGA HIROFUMI ,  NISHIKAWA KENJI ,  KIMURA TOMIO

IPC分类号： C07D333/36 ,  A61K31/381 ,  A61K31/427 ,  A61K31/443 ,  A61P13/00 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07D409/04 ,  C07D409/14 ,  C07D417/12

CPC分类号： C07D333/36 ,  A61K31/381 ,  A61K31/427 ,  A61K31/443 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12

摘要： A novel ±-halogen-substituted thiophene compound or a pharmacologically acceptable salt thereof, which has a potent LPA receptor-antagonist activity and is useful as a medicament is provided. A compound represented by the general formula (I) wherein A represents, a phenyl ring, a thiophene ring, or an isothiazole ring; R 1 is the same or different, and represents a halogen atom, or a C 1 -C 3 alkyl group; R 2 represents a hydrogen atom, or a C 1 -C 6 alkyl group; p represents an integer of 0 to 5; V represents CR 3 wherein R 3 represents a hydrogen atom, an amino group, a nitro group, or a C 1 -C 3 alkoxy group, or V represents a nitrogen atom; and X represents a halogen atom, or a salt thereof.

公开(公告)号：EP2511276A4

公开(公告)日：2012-12-19

申请号：EP10804402

申请日：2010-07-27

申请人： UBE INDUSTRIES

发明人： TSUBOIKE KAZUNARI ,  MIZUNO GEN ,  NISHIDA HIROSHI ,  KONO SHIGEYUKI ,  TOYOTA AKIKO ,  TANZAWA FUMIE ,  FUJIWARA KOSAKU

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P35/00 ,  A61P35/02 ,  A61P43/00

CPC分类号： C07D487/04

公开(公告)号：EP3162801A1

公开(公告)日：2017-05-03

申请号：EP15812460

申请日：2015-06-26

申请人： UBE INDUSTRIES

发明人： IWASE NORIAKI ,  NISHIDA HIROSHI ,  OKUDO MAKOTO ,  ITO MASAAKI ,  KONO SHIGEYUKI ,  MATOYAMA MASAAKI ,  USHIYAMA SHIGERU ,  OKANARI EIJI ,  MATSUNAGA HIROFUMI ,  NISHIKAWA KENJI ,  KIMURA TOMIO

IPC分类号： C07D333/36 ,  A61K31/381 ,  A61P13/00 ,  A61P19/04 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00

CPC分类号： C07D333/36 ,  A61K31/381

摘要： The invention provides a novel ±-halogen-substituted thiophene compound salt that has a potent LPA receptor antagonistic action and is useful as a medicament. The salt is represented by the general formula (I): (wherein R is a hydrogen atom or a methoxy group; X is a halogen atom; A is selected from the group consisting of: ;M is an alkali metal or an alkaline earth metal; and n is 1 when M is an alkali metal and is 2 when M is an alkaline earth metal).

摘要翻译： 本发明提供了一种新的±卤素取代的噻吩化合物盐，其具有有效的LPA受体拮抗作用并可用作药物。 该盐由通式（I）表示：（其中R是氢原子或甲氧基; X是卤素原子; A选自：; M是碱金属或碱土金属 ;当M是碱金属时n是1，当M是碱土金属时n是2）。

公开(公告)号：EP3214086A4

公开(公告)日：2018-04-18

申请号：EP15855181

申请日：2015-10-30

申请人： UBE INDUSTRIES

发明人： AGA YASUHIRO ,  USHIYAMA SHIGERU ,  IWASE NORIAKI ,  KONO SHIGEYUKI ,  SUNAMOTO HIDETOSHI ,  MATSUSHITA TAKASHI ,  OGI SAYAKA ,  TANAKA MASAYUKI ,  MATOYAMA MASAAKI ,  UMEZAKI SATOSHI ,  SHIRAISHI YUSUKE ,  ONUMA KAZUHIRO ,  KOJIMA MASAHIRO ,  NISHIYAMA HAYATO ,  KIMURA TOMIO

IPC分类号： C07F7/10 ,  A61K31/695 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00

CPC分类号： C07F7/10 ,  A61K31/695 ,  Y02P20/55

摘要： Provided is a compound represented by formula (I) or a pharmacologically acceptable salt thereof: wherein L 1 is an optionally substituted C 1-6 alkylene group or the like, L 2 is a single bond or the like, L 3 is a single bond or the like, R 1 , R 2 , and R 3 are each independently an optionally substituted C 1-4 alkyl group or the like, R 4 is a hydrogen atom or the like, and R 5 is a hydrogen atom or the like.

公开(公告)号：EP3162801A4

公开(公告)日：2018-01-24

申请号：EP15812460

申请日：2015-06-26

申请人： UBE INDUSTRIES

发明人： IWASE NORIAKI ,  NISHIDA HIROSHI ,  OKUDO MAKOTO ,  ITO MASAAKI ,  KONO SHIGEYUKI ,  MATOYAMA MASAAKI ,  USHIYAMA SHIGERU ,  OKANARI EIJI ,  MATSUNAGA HIROFUMI ,  NISHIKAWA KENJI ,  KIMURA TOMIO

IPC分类号： C07D333/36 ,  A61K31/381 ,  A61P13/00 ,  A61P19/04 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00

CPC分类号： C07D333/36 ,  A61K31/381

摘要： The invention provides a novel ±-halogen-substituted thiophene compound salt that has a potent LPA receptor antagonistic action and is useful as a medicament. The salt is represented by the general formula (I): (wherein R is a hydrogen atom or a methoxy group; X is a halogen atom; A is selected from the group consisting of: ;M is an alkali metal or an alkaline earth metal; and n is 1 when M is an alkali metal and is 2 when M is an alkaline earth metal).