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公开(公告)号：EP2592076B1
公开(公告)日：2015-05-13
申请号：EP11803677.1
申请日：2011-07-08
发明人： NAKAMURA, Tsuyoshi , NAMIKI, Hidenori , TERASAKA, Naoki , SHIMA, Akiko , HAGIHARA, Masahiko , IWASE, Noriaki , TAKATA, Katsunori , KIKUCHI, Osamu , TSUBOIKE, Kazunari , SETOGUCHI, Hiroyuki , YONEDA, Kenji , SUNAMOTO, Hidetoshi , ITO, Koji
IPC分类号： C07D401/14 , A61K31/506 , A61K31/5377 , A61K31/541 , A61P3/04 , A61P3/06 , A61P9/10 , A61P43/00
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07F7/1804
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2.发明授权NOVEL INDAZOLE DERIVATIVE OR SALT THEREOF, MANUFACTURING INTERMEDIATE THEREFOR, ANTIOXIDANT USING SAME, AND USE FOR AN INDAZOLE DERIVATIVE OR SALT THEREOF 有权NEW吲唑或其盐，A及其中间体，抗氧化剂和正确使用FOR A吲唑衍生物或其盐制备方法
公开(公告)号：EP2578219B1
公开(公告)日：2014-10-01
申请号：EP11786710.1
申请日：2011-05-26
申请人： Ube Industries, Ltd.
发明人： HAGIHARA, Masahiko , KOMORI, Ken-ichi , SUNAMOTO, Hidetoshi , NISHIDA, Hiroshi , TSUZAKI, Yasunori , TAKAMA, Akira , KIDO, Kazutaka , FUJIMOTO, Tomokazu , MATSUGI, Takeshi
IPC分类号： A61K31/4439 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/06 , A61P3/10 , A61P7/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/02 , A61P17/06 , A61P25/16 , A61P25/28 , A61P27/02 , A61P27/04 , A61P27/06
CPC分类号： C07D401/14 , C07D401/04 , C07D401/10 , C07D405/14
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公开(公告)号：EP2592076A1
公开(公告)日：2013-05-15
申请号：EP11803677.1
申请日：2011-07-08
发明人： NAKAMURA, Tsuyoshi , NAMIKI, Hidenori , TERASAKA, Naoki , SHIMA, Akiko , HAGIHARA, Masahiko , IWASE, Noriaki , TAKATA, Katsunori , KIKUCHI, Osamu , TSUBOIKE, Kazunari , SETOGUCHI, Hiroyuki , YONEDA, Kenji , SUNAMOTO, Hidetoshi , ITO, Koji
IPC分类号： C07D401/14 , A61K31/506 , A61K31/5377 , A61K31/541 , A61P3/04 , A61P3/06 , A61P9/10 , A61P43/00
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07F7/1804
摘要： The present invention provides a substituted pyridine compound or a pharmacologically acceptable salt thereof which has excellent CETP inhibition activity and is useful as a medicament. The present invention provides a compound represented by a general formula (I),
wherein R 1 is H, optionally substituted alkyl, OH, optionally substituted alkoxy, alkylsulfonyl, optionally substituted amino, carboxy, optionally substituted carbonyl, CN, halogeno, optionally substituted phenyl, optionally substituted aromatic heterocyclyl, optionally substituted saturated heterocyclyl, optionally substituted saturated heterocyclyloxy or optionally substituted saturated heterocyclylcarbonyl, etc., and the like.摘要翻译： 本发明提供具有优异的CETP抑制活性并且可用作药物的取代吡啶化合物或其药理学上可接受的盐。 本发明提供由通式（I）表示的化合物，其中R1为H，任选取代的烷基，OH，任选取代的烷氧基，烷基磺酰基，任选取代的氨基，羧基，任选取代的羰基，CN，卤代，任选取代的苯基， 任选取代的芳族杂环基，任选取代的饱和杂环基，任选取代的饱和杂环氧基或任选取代的饱和杂环基羰基等等。
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公开(公告)号：EP2468729A1
公开(公告)日：2012-06-27
申请号：EP12160543.0
申请日：2004-10-15
发明人： HAGIHARA, Masahiko , KOMORI, Ken-ichi , SUNAMOTO, Hidetoshi , NISHIDA, Hiroshi , MATSUGI, Takeshi , NAKAJIMA, Tadashi , HATANO, Masakazu , KIDO, Kazutaka , HARA, Hideaki
IPC分类号： C07D231/56 , C07D401/04 , A61K31/416 , A61K31/4439 , A61P27/06 , A61P43/00 , C07D403/04 , C07D413/04
CPC分类号： C07D231/56 , C07D401/04 , C07D403/04 , C07D413/04
摘要： The invention relates to compounds of formula (I):
in which R 1 , R 2 , R 3 , R 4 , R 5 and X are as defined in the description. These compounds are useful as Rho kinase inhibitors.摘要翻译： 本发明涉及式（I）化合物：其中R 1，R 2，R 3，R 4，R 5和X如说明书中所定义。 这些化合物可用作Rho激酶抑制剂。
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公开(公告)号：EP3214086A1
公开(公告)日：2017-09-06
申请号：EP15855181.2
申请日：2015-10-30
申请人： Ube Industries, Ltd.
发明人： AGA, Yasuhiro , USHIYAMA, Shigeru , IWASE, Noriaki , KONO, Shigeyuki , SUNAMOTO, Hidetoshi , MATSUSHITA, Takashi , OGI, Sayaka , TANAKA, Masayuki , MATOYAMA, Masaaki , UMEZAKI, Satoshi , SHIRAISHI, Yusuke , ONUMA, Kazuhiro , KOJIMA, Masahiro , NISHIYAMA, Hayato , KIMURA, Tomio
CPC分类号： C07F7/10 , A61K31/695 , Y02P20/55
摘要： Provided is a compound represented by formula (I) or a pharmacologically acceptable salt thereof:
wherein L 1 is an optionally substituted C 1-6 alkylene group or the like, L 2 is a single bond or the like, L 3 is a single bond or the like, R 1 , R 2 , and R 3 are each independently an optionally substituted C 1-4 alkyl group or the like, R 4 is a hydrogen atom or the like, and R 5 is a hydrogen atom or the like.摘要翻译： 提供由式（I）表示的化合物或其药理学上可接受的盐：其中L 1是任选取代的C 1-6亚烷基等，L 2是单键等，L 3是单键等， R1，R2和R3各自独立地为任选取代的C1-4烷基等，R4为氢原子等，R5为氢原子等。
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公开(公告)号：EP2468729B1
公开(公告)日：2013-12-25
申请号：EP12160543.0
申请日：2004-10-15
申请人： Ube Industries, Ltd.
发明人： HAGIHARA, Masahiko , KOMORI, Ken-ichi , SUNAMOTO, Hidetoshi , NISHIDA, Hiroshi , MATSUGI, Takeshi , NAKAJIMA, Tadashi , HATANO, Masakazu , KIDO, Kazutaka , HARA, Hideaki
IPC分类号： C07D231/56 , C07D401/04 , A61K31/416 , A61K31/4439 , A61P27/06 , A61P43/00 , C07D403/04 , C07D413/04
CPC分类号： C07D231/56 , C07D401/04 , C07D403/04 , C07D413/04
摘要： An object of the present invention is to create a novel indazole derivative useful as a drug and to find a novel pharmacological action of the derivative. The compound of the present invention is represented by the formula [I] and has an excellent Rho kinase inhibiting action. In the formula, a ring X is a benzene ring or a pyridine ring; R 1 and R 2 are H or alkyl; R 3 and R 4 are halogen, H, OH, alkoxy, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, aryloxy, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, carboxy, hydrocarbonyl, alkylcarbonyl, etc.; and R 5 is halogen atom, H, OH, alkoxy, aryloxy, alkyl or aryl. Each group can be substituted.
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7.发明公开NOVEL INDAZOLE DERIVATIVE OR SALT THEREOF, MANUFACTURING INTERMEDIATE THEREFOR, ANTIOXIDANT USING SAME, AND USE FOR AN INDAZOLE DERIVATIVE OR SALT THEREOF 有权NEW吲唑或其盐，A及其中间体，抗氧化剂和正确使用FOR A吲唑衍生物或其盐制备方法
公开(公告)号：EP2578219A1
公开(公告)日：2013-04-10
申请号：EP11786710.1
申请日：2011-05-26
申请人： Ube Industries, Ltd.
发明人： HAGIHARA, Masahiko , KOMORI, Ken-ichi , SUNAMOTO, Hidetoshi , NISHIDA, Hiroshi , TSUZAKI, Yasunori , TAKAMA, Akira , KIDO, Kazutaka , FUJIMOTO, Tomokazu , MATSUGI, Takeshi
IPC分类号： A61K31/4439 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/06 , A61P3/10 , A61P7/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/02 , A61P17/06 , A61P25/16 , A61P25/28 , A61P27/02 , A61P27/04 , A61P27/06
CPC分类号： C07D401/14 , C07D401/04 , C07D401/10 , C07D405/14
摘要： A compound represented by formula (1) or salt thereof and a production intermediate thereof are created. The compound exhibited an excellent antioxidation action in a microsome lipid peroxidation measuring system using a rat liver microsome. Therefore, the compound or salt thereof is useful as an antioxidant. The present invention also provides use of a compound represented by the formula (1) or a pharmaceutically acceptable salt thereof for production of an antioxidant.
摘要翻译： 由式（1）或其盐和一种生产中间表示的化合物或其被创建。 化合物显示在微粒体脂质过氧化的测量系统使用大鼠肝微粒优良的抗氧化作用。 因此，该化合物或其盐是作为抗氧化剂是有用的。 本发明因此提供了式（1）或用于生产抗氧化剂的药学上可接受的盐表示的化合物。
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