公开(公告)号：EP3311168A1

公开(公告)日：2018-04-25

申请号：EP15784067.9

申请日：2015-10-22

申请人： UCB Biopharma SPRL

发明人： O'CONNELL, James Philip ,  PORTER, John Robert ,  LAWSON, Alastair ,  KROEPLIEN, Boris ,  RAPECKI, Stephen Edward ,  NORMAN, Timothy John ,  WARRELLOW, Graham John ,  ARAKAKI, Tracy Lynn ,  BURGIN, Alex Buntin ,  PITT, William Ross ,  CALMIANO, Mark Daniel ,  SCHUBERT, David Andreas ,  LIGHTWOOD, Daniel John ,  WOOTTON, Rebecca Jayne

IPC分类号： G01N33/68 ,  C07K14/705 ,  C07K14/525 ,  C07D401/14 ,  C07D471/00

CPC分类号： G01N33/6845 ,  A61K47/6425 ,  A61P35/00 ,  A61P37/00 ,  C07D213/72 ,  C07D235/04 ,  C07D239/26 ,  C07D401/14 ,  C07D471/00 ,  C07D471/04 ,  C07K14/525 ,  C07K14/70575 ,  C07K16/241 ,  C07K2317/55 ,  C07K2317/92 ,  G01N33/6854 ,  G01N33/6863 ,  G01N2333/525 ,  G01N2500/02

摘要： The invention is in the field of TNF signalling. Compounds have been identified which are capable of modulating signalling of TNF trimers through receptors. Methods of identifying such compounds are therefore provided. The compounds themselves have utility in therapy.