公开(公告)号：EP1755684B1

公开(公告)日：2016-08-31

申请号：EP05746563.5

申请日：2005-05-25

申请人： UCB Biopharma SPRL

发明人： EATON, Michael Anthony William ,  NORMAN, Timothy John ,  PORTER, John Robert

IPC分类号： A61K47/48

CPC分类号： A61K47/542 ,  A61K47/60

公开(公告)号：EP3311169A1

公开(公告)日：2018-04-25

申请号：EP15784069.5

申请日：2015-10-22

申请人： UCB Biopharma SPRL

发明人： O'CONNELL, James Philip ,  PORTER, John Robert ,  LAWSON, Alastair ,  KROEPLIEN, Boris ,  RAPECKI, Stephen Edward ,  NORMAN, Timothy John ,  WARRELLOW, Graham John

IPC分类号： G01N33/68 ,  C07D401/14 ,  C07K14/525 ,  C07D471/00 ,  C07K14/705

CPC分类号： G01N33/6845 ,  A61K47/6425 ,  A61P35/00 ,  A61P37/00 ,  C07D213/72 ,  C07D235/04 ,  C07D239/26 ,  C07D401/14 ,  C07D471/00 ,  C07D471/04 ,  C07K14/525 ,  C07K14/70575 ,  C07K16/241 ,  C07K2317/55 ,  C07K2317/92 ,  G01N33/6854 ,  G01N33/6863 ,  G01N2333/525 ,  G01N2500/02

摘要： The invention is in the field of TNF signalling. Compounds have been identified which are capable of modulating signalling of TNF trimers through receptors. Methods of identifying such compounds are therefore provided. The compounds themselves have utility in therapy.

公开(公告)号：EP3519423A1

公开(公告)日：2019-08-07

申请号：EP17781040.5

申请日：2017-09-27

申请人： UCB Biopharma SPRL

发明人： BAKER, Terence Seward ,  EATON, Michael Anthony William ,  NORMAN, Timothy John ,  TURNER, James Petrie

IPC分类号： C07J51/00 ,  C07F9/09 ,  A61K31/575 ,  A61K31/661

公开(公告)号：EP3311168A1

公开(公告)日：2018-04-25

申请号：EP15784067.9

申请日：2015-10-22

申请人： UCB Biopharma SPRL

发明人： O'CONNELL, James Philip ,  PORTER, John Robert ,  LAWSON, Alastair ,  KROEPLIEN, Boris ,  RAPECKI, Stephen Edward ,  NORMAN, Timothy John ,  WARRELLOW, Graham John ,  ARAKAKI, Tracy Lynn ,  BURGIN, Alex Buntin ,  PITT, William Ross ,  CALMIANO, Mark Daniel ,  SCHUBERT, David Andreas ,  LIGHTWOOD, Daniel John ,  WOOTTON, Rebecca Jayne

IPC分类号： G01N33/68 ,  C07K14/705 ,  C07K14/525 ,  C07D401/14 ,  C07D471/00

CPC分类号： G01N33/6845 ,  A61K47/6425 ,  A61P35/00 ,  A61P37/00 ,  C07D213/72 ,  C07D235/04 ,  C07D239/26 ,  C07D401/14 ,  C07D471/00 ,  C07D471/04 ,  C07K14/525 ,  C07K14/70575 ,  C07K16/241 ,  C07K2317/55 ,  C07K2317/92 ,  G01N33/6854 ,  G01N33/6863 ,  G01N2333/525 ,  G01N2500/02

摘要： The invention is in the field of TNF signalling. Compounds have been identified which are capable of modulating signalling of TNF trimers through receptors. Methods of identifying such compounds are therefore provided. The compounds themselves have utility in therapy.

公开(公告)号：EP3311167A1

公开(公告)日：2018-04-25

申请号：EP15784066.1

申请日：2015-10-22

申请人： UCB Biopharma SPRL

发明人： O'CONNELL, James Philip ,  PORTER, John Robert ,  LAWSON, Alastair ,  KROEPLIEN, Boris, ,  RAPECKI, Stephen Edward ,  NORMAN, Timothy John ,  MCMILLAN, David James ,  WARRELLOW, Graham John ,  BROOKINGS, Daniel Christopher ,  ALEXANDER, Rikki Peter

IPC分类号： G01N33/68 ,  C07D401/14 ,  C07K14/525 ,  C07D471/00 ,  C07K14/705

摘要： The invention is in the field of TNF signalling. Compounds have been identified which are capable of modulating signalling of TNF trimers through receptors. Methods of identifying such compounds are therefore provided. The compounds themselves have utility in therapy.

公开(公告)号：EP3303318A1

公开(公告)日：2018-04-11

申请号：EP16728291.2

申请日：2016-06-07

申请人： UCB Biopharma SPRL

发明人： BRACE, Gareth Neil ,  CHOVATIA, Prafulkumar Tulshibhai ,  FOULKES, Gregory ,  JOHNSON, James Andrew ,  JONES, Severine Danielle ,  KROEPLIEN, Boris ,  LECOMTE, Fabien Claude ,  LOKE, Pui Leng ,  LOWE, Martin Alexander ,  MANDAL, Ajay ,  NORMAN, Timothy John ,  PALMER, Christopher Francis ,  PÉREZ-FUERTES, Yolanda ,  PORTER, John Robert ,  SMYTH, Donald ,  TRANI, Giancarlo ,  UDDIN, Muhammed ,  ZHU, Zhaoning

IPC分类号： C07D401/06 ,  C07D413/06 ,  C07D498/04 ,  A61K31/517 ,  A61K31/519 ,  A61P29/00

CPC分类号： C07D498/04 ,  A61K31/423 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/473 ,  A61K31/538 ,  A61K31/5383 ,  A61K31/55 ,  A61P3/00 ,  A61P9/00 ,  A61P23/00 ,  A61P25/00 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  C07D401/06 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D519/00

摘要： A series of substituted 3,4-dihydro-2H-.1,4-benzoxazin-3-one derivatives, and analogues thereof, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neuradegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.