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公开(公告)号：EP2423226A3
公开(公告)日：2012-05-30
申请号：EP11179368.3
申请日：2007-11-09
申请人： Amgen Inc. , UCB Pharma, S.A.
发明人： Robinson, Martyn Kim , Paszty, Christopher J. , Lawson, Alistair , Popplewell, Andy , Henry, Alistair James
IPC分类号： C07K16/22 , A61K39/395
CPC分类号： C07K16/18 , C07K16/22 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Compositions and methods relating to sclerostin binding agents, such as antibodies and polypeptides capable of binding to sclerostin, are provided.
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公开(公告)号：EP2336163A1
公开(公告)日：2011-06-22
申请号：EP10014375.9
申请日：2006-04-28
申请人： UCB Pharma S.A. , Amgen, Inc
发明人： Paszty, Christopher , Robinson, Martyn Kim , Graham, Kevin , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Lu, Hsieng Sen , Popplewell, Andy , Shen, Wenyan , Winkler, David , Winters, Aaron George
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin-binding agents, such as antibodies capable of binding to sclerostin, are provided.
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公开(公告)号：EP2423226A2
公开(公告)日：2012-02-29
申请号：EP11179368.3
申请日：2007-11-09
申请人： Amgen Inc. , UCB Pharma, S.A.
发明人： Robinson, Martyn Kim , Paszty, Christopher J. , Lawson, Alistair , Popplewell, Andy , Henry, Alistair James
IPC分类号： C07K16/22 , A61K39/395
CPC分类号： C07K16/18 , C07K16/22 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Compositions and methods relating to sclerostin binding agents, such as antibodies and polypeptides capable of binding to sclerostin, are provided.
摘要翻译： 提供了与软骨素结合剂相关的组合物和方法，例如能够结合硬化蛋白的抗体和多肽。
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公开(公告)号：EP2325199A1
公开(公告)日：2011-05-25
申请号：EP10014362.7
申请日：2006-04-28
申请人： UCB Pharma S.A. , Amgen, Inc
发明人： Paszty, Christopher , Robinson, Martyn Kim , Graham, Kevin , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Lu, Hsieng Sen , Winters, Aaron George , Winkler, David , Shen, Wenyan , Popplewell, Andy
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin-binding agents, such as antibodies capable of binding to sclerostin, are provided.
摘要翻译： 提供了与硬骨素蛋白的表位和硬化素结合剂相关的组合物和方法，例如能够结合硬骨素的抗体。
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公开(公告)号：EP2301961A1
公开(公告)日：2011-03-30
申请号：EP10014373.4
申请日：2006-04-28
申请人： UCB Pharma, S.A. , Amgen, Inc.
发明人： Lu, Hsieng Sen , Paszty, Christopher , Robinson, Martyn Kim , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Winkler, David , Winters, Aaron George
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/51 , C07K16/22 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/63
摘要： The invention relates to polypeptide fragments of sclerostin and antibodies that bind to the fragments. The antibodies are useful in treating diseases of low bone density, such as osteoporosis, and in accelerating the healing of bone fractures.
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公开(公告)号：EP2345668A1
公开(公告)日：2011-07-20
申请号：EP10014360.1
申请日：2006-04-28
申请人： UCB Pharma, S.A. , Amgen, Inc.
发明人： Lu, Hsieng Sen , Paszty, Christopher , Robinson, Martyn Kim , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Winkler, David , Winters, Aaron George
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/51 , C07K16/22 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/63
摘要： The invention relates to polypeptide fragments of sclerostin and antibodies that bind to the fragments. The antibodies are useful in treating diseases of low bone density, such as osteoporosis, and in accelerating the healing of bone fractures.
摘要翻译： 本发明涉及结合片段的硬化蛋白的多肽片段和抗体。 该抗体可用于治疗低骨密度疾病，如骨质疏松症，以及加速骨折愈合。
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公开(公告)号：EP2298800A1
公开(公告)日：2011-03-23
申请号：EP10014361.9
申请日：2006-04-28
申请人： UCB Pharma, S.A. , Amgen, Inc.
发明人： Lu, Hsieng Sen , Paszty, Christopher , Robinson, Martyn Kim , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Winkler, David , Winters, Aaron George
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/51 , C07K16/22 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/63
摘要： The invention relates to polypeptide fragments of sclerostin and antibodies that bind to the fragments. The antibodies are useful in treating diseases of low bone density, such as osteoporosis, and in accelerating the healing of bone fractures.
摘要翻译： 本发明涉及结合片段的硬化蛋白的多肽片段和抗体。 该抗体可用于治疗低骨密度疾病，如骨质疏松症，以及加速骨折愈合。
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公开(公告)号：EP2325200A1
公开(公告)日：2011-05-25
申请号：EP10014374.2
申请日：2006-04-28
申请人： UCB Pharma S.A. , Amgen, Inc
发明人： Paszty, Christopher , Robinson, Martyn Kim , Graham, Kevin , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Lu, Hsieng Sen , Popplewell, Andy , Shen, Wenyan , Winkler, David , Winters, Aaron George
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin-binding agents, such as antibodies capable of binding to sclerostin, are provided.
摘要翻译： 提供了与硬骨素蛋白表位有关的组合物和方法，以及硬骨素结合剂，例如能结合硬化蛋白的抗体。
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公开(公告)号：EP2295448A1
公开(公告)日：2011-03-16
申请号：EP10014372.6
申请日：2006-04-28
申请人： UCB Pharma, S.A. , Amgen, Inc.
发明人： Lu, Hsieng Sen , Paszty, Christopher , Robinson, Martyn Kim , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Winkler, David , Winters, Aaron George
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/51 , C07K16/22 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/63
摘要： The invention relates to polypeptide fragments of sclerostin and antibodies that bind to the fragments. The antibodies are useful in treating diseases of low bone density, such as osteoporosis, and in accelerating the healing of bone fractures.
摘要翻译： 本发明涉及硬骨素的多肽片段和结合该片段的抗体。 该抗体可用于治疗骨密度低的疾病，如骨质疏松症，以及加速骨折愈合。
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公开(公告)号：EP2264063A1
公开(公告)日：2010-12-22
申请号：EP10008795.6
申请日：2006-04-28
申请人： UCB Pharma, S.A. , Amgen, Inc
发明人： Paszty, Christopher , Robinson, Marty Kim , Graham, Kevin , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Lu, Hsieng Sen , Popplewell, Andy , Shen, Wenyan , Winkler, David , Winters, Aaron George
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
摘要翻译： 提供了与软骨素蛋白表位有关的组合物和方法，以及硬骨素结合剂，例如能结合硬化蛋白的抗体。
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