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公开(公告)号：EP2325199A1
公开(公告)日：2011-05-25
申请号：EP10014362.7
申请日：2006-04-28
申请人： UCB Pharma S.A. , Amgen, Inc
发明人： Paszty, Christopher , Robinson, Martyn Kim , Graham, Kevin , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Lu, Hsieng Sen , Winters, Aaron George , Winkler, David , Shen, Wenyan , Popplewell, Andy
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin-binding agents, such as antibodies capable of binding to sclerostin, are provided.
摘要翻译： 提供了与硬骨素蛋白的表位和硬化素结合剂相关的组合物和方法，例如能够结合硬骨素的抗体。
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公开(公告)号：EP2325200A1
公开(公告)日：2011-05-25
申请号：EP10014374.2
申请日：2006-04-28
申请人： UCB Pharma S.A. , Amgen, Inc
发明人： Paszty, Christopher , Robinson, Martyn Kim , Graham, Kevin , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Lu, Hsieng Sen , Popplewell, Andy , Shen, Wenyan , Winkler, David , Winters, Aaron George
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin-binding agents, such as antibodies capable of binding to sclerostin, are provided.
摘要翻译： 提供了与硬骨素蛋白表位有关的组合物和方法，以及硬骨素结合剂，例如能结合硬化蛋白的抗体。
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公开(公告)号：EP2264063A1
公开(公告)日：2010-12-22
申请号：EP10008795.6
申请日：2006-04-28
申请人： UCB Pharma, S.A. , Amgen, Inc
发明人： Paszty, Christopher , Robinson, Marty Kim , Graham, Kevin , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Lu, Hsieng Sen , Popplewell, Andy , Shen, Wenyan , Winkler, David , Winters, Aaron George
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
摘要翻译： 提供了与软骨素蛋白表位有关的组合物和方法，以及硬骨素结合剂，例如能结合硬化蛋白的抗体。
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公开(公告)号：EP2336163A1
公开(公告)日：2011-06-22
申请号：EP10014375.9
申请日：2006-04-28
申请人： UCB Pharma S.A. , Amgen, Inc
发明人： Paszty, Christopher , Robinson, Martyn Kim , Graham, Kevin , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Lu, Hsieng Sen , Popplewell, Andy , Shen, Wenyan , Winkler, David , Winters, Aaron George
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin-binding agents, such as antibodies capable of binding to sclerostin, are provided.
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公开(公告)号：EP2264063B1
公开(公告)日：2018-06-27
申请号：EP10008795.6
申请日：2006-04-28
申请人： UCB Pharma, S.A.
发明人： Paszty, Christopher , Robinson, Marty Kim , Graham, Kevin , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Lu, Hsieng Sen , Popplewell, Andy , Shen, Wenyan , Winkler, David , Winters, Aaron George
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.
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公开(公告)号：EP2489731B1
公开(公告)日：2014-08-27
申请号：EP12003811.2
申请日：2008-07-25
申请人： Amgen, Inc
发明人： Zhou, Mingyue , Boone, Thomas Charles , Meininger, David Park , Schwarz, Margit , Shan, Bei , Shen, Wenyan
CPC分类号： C12N9/1029 , A61K47/68 , C12Y203/01043
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7.发明公开Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9) 审中-公开抗原结合蛋白与前蛋白转化酶枯草杆菌蛋白酶/可心9型（PCSK9）
公开(公告)号：EP2641917A3
公开(公告)日：2014-02-19
申请号：EP13151352.5
申请日：2008-08-22
申请人： Amgen Inc.
发明人： Jackson, Simon Mark , Walker, Nigel Pelham Clinton , Piper, Derek Evan , Shan, Bei , Shen, Wenyan , Chan, Joyce Chi Yee , King, Chadwick Terence , Ketchem, Randal Robert , Mehlin, Christopher , Carabeo, Teresa Arazas , Cao, Qiong
IPC分类号： C07K16/40 , A61P3/06 , A61K39/395 , A61K45/06 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/505 , A61K31/66 , A61K31/47 , A61K39/00
摘要： Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.
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公开(公告)号：EP2641918A2
公开(公告)日：2013-09-25
申请号：EP13151381.4
申请日：2008-08-22
申请人： Amgen Inc.
发明人： Jackson, Simon Mark , Walker, Nigel Pelham Clinton , Piper, Derek Evan , Shan, Bei , Shen, Wenyan , Chan, Joyce Chi Yee , King, Chadwick Terence , Ketchem, Randal Robert , Mehlin, Christopher , Carabeo, Teresa , Cao, Qiong
IPC分类号： C07K16/40 , A61P3/06 , A61K39/395 , A61K45/06 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , A61K31/505 , A61K31/66
CPC分类号： C07K16/40 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , A61K31/505 , A61K31/66 , A61K39/395 , A61K45/06 , A61K2039/505 , C07K2299/00 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.
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公开(公告)号：EP2641917B1
公开(公告)日：2020-05-06
申请号：EP13151352.5
申请日：2008-08-22
申请人： Amgen Inc.
发明人： Jackson, Simon Mark , Walker, Nigel Pelham Clinton , Piper, Derek Evan , Shan, Bei , Shen, Wenyan , Chan, Joyce Chi Yee , King, Chadwick Terence , Ketchem, Randal Robert , Mehlin, Christopher , Carabeo, Teresa Arazas , Cao, Qiong
IPC分类号： C07K16/40 , A61P3/06 , A61K39/395 , A61K45/06 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/505 , A61K31/66 , A61K31/47 , A61K39/00
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公开(公告)号：EP2325199B1
公开(公告)日：2015-03-04
申请号：EP10014362.7
申请日：2006-04-28
申请人： AMGEN, INC.
发明人： Paszty, Christopher , Robinson, Martyn Kim , Graham, Kevin , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Lu, Hsieng Sen , Winters, Aaron George , Winkler, David , Shen, Wenyan , Popplewell, Andy
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
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