公开(公告)号：EP2645997A2

公开(公告)日：2013-10-09

申请号：EP11791442.4

申请日：2011-12-01

申请人： UCB Pharma GmbH

发明人： CAWELLO, Willi ,  SCHUBERT, Martin, Alexander

IPC分类号： A61K9/16 ,  A61K9/20 ,  A61K31/165 ,  A61P25/08 ,  A61P25/14 ,  A61P25/18

CPC分类号： A61K31/165 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/2027 ,  A61K9/205 ,  A61K9/2054 ,  A61K9/2866 ,  A61K9/4891 ,  A61K9/50

摘要： A modified release formulation of lacosamide suitable for once-daily administration.

公开(公告)号：EP2922533A1

公开(公告)日：2015-09-30

申请号：EP13795432.7

申请日：2013-11-21

申请人： UCB Pharma GmbH ,  LTS LOHMANN Therapie-Systeme AG

发明人： CAWELLO, Willi ,  LAPPERT, Aurelia ,  KASSNER, Kristina ,  WOLFF, Hans-Michael ,  MÜLLER, Walter ,  LEONHARD, Johannes Josef ,  EMGENBROICH, Marco

IPC分类号： A61K9/70 ,  A61K31/381

CPC分类号： A61K9/7092 ,  A61K9/7069 ,  A61K9/7084 ,  A61K31/381 ,  B32B37/12 ,  B32B2556/00

摘要： The present invention relates to a transdermal therapeutic system, comprising (a) a backing layer, (b) a solvent -based self-adhesive matrix layer containing rotigotine as active ingredient, and (c) a release liner, wherein the self- adhesive matrix layer has a coating weight of about 75-400 g/m
2 and comprises a reservoir layer containing about 9-25 wt.-% rotigotine based on the weight of the reservoir layer, a kit comprising two transdermal therapeutic systems of the present invention as well as a method for the preparation of the transdermal therapeutic system of the present invention. In addition, the present invention relates to a transdermal therapeutic system comprising rotigotine as active ingredient for use in the treatment of patients suffering from Parkinson's disease, Parkinson's plus syndrome, depression, fibromyalgia and the restless-legs syndrome and for use in the treatment or prevention of dopaminergic neuron loss or cognitive disorders by transdermal administration of rotigotine once or twice weekly, wherein the transdermal therapeutic system comprises a backing layer, a solvent -based rotigotine containing self-adhesive matrix layer as well as a release liner and is adapted to allow for the transdermal administration of therapeutically effective amounts of rotigotine for at least 3 days.

公开(公告)号：EP2646001A2

公开(公告)日：2013-10-09

申请号：EP11817472.1

申请日：2011-12-01

申请人： UCB Pharma GmbH

发明人： CAWELLO, Willi ,  SCHUBERT, Martin, Alexander

IPC分类号： A61K9/16 ,  A61K9/20 ,  A61K31/165 ,  A61P25/08 ,  A61P25/14 ,  A61P25/18

CPC分类号： A61K31/165 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/2027 ,  A61K9/205 ,  A61K9/2054 ,  A61K9/2866 ,  A61K9/4891 ,  A61K9/50

摘要： A modified release formulation of lacosamide.

摘要翻译： 拉科酰胺的改性释放制剂。

公开(公告)号：EP3766485A1

公开(公告)日：2021-01-20

申请号：EP20188230.5

申请日：2011-12-01

申请人： UCB Pharma GmbH

发明人： CAWELLO, Willi ,  SCHUBERT, Martin Alexander

IPC分类号： A61K9/28 ,  A61K9/50 ,  A61K31/165 ,  A61P25/08 ,  A61P25/14 ,  A61P25/18 ,  A61P25/00 ,  A61K9/20 ,  A61K9/16

摘要： A modified release formulation of lacosamide suitable for once-daily adminsitration.