利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

5 条记录 (耗时 0.016 秒)

    MULTI-DAY PATCH FOR THE TRANSDERMAL ADMINISTRATION OF ROTIGOTINE
    1.
    发明公开
    MULTI-DAY PATCH FOR THE TRANSDERMAL ADMINISTRATION OF ROTIGOTINE 有权
    几天补丁罗替高汀透皮给药

    公开(公告)号：EP2922533A1

    公开(公告)日：2015-09-30

    申请号：EP13795432.7

    申请日：2013-11-21

    申请人： UCB Pharma GmbH ,  LTS LOHMANN Therapie-Systeme AG

    发明人： CAWELLO, Willi ,  LAPPERT, Aurelia ,  KASSNER, Kristina ,  WOLFF, Hans-Michael ,  MÜLLER, Walter ,  LEONHARD, Johannes Josef ,  EMGENBROICH, Marco

    IPC分类号： A61K9/70 ,  A61K31/381

    CPC分类号： A61K9/7092 ,  A61K9/7069 ,  A61K9/7084 ,  A61K31/381 ,  B32B37/12 ,  B32B2556/00

    摘要： The present invention relates to a transdermal therapeutic system, comprising (a) a backing layer, (b) a solvent -based self-adhesive matrix layer containing rotigotine as active ingredient, and (c) a release liner, wherein the self- adhesive matrix layer has a coating weight of about 75-400 g/m
    2 and comprises a reservoir layer containing about 9-25 wt.-% rotigotine based on the weight of the reservoir layer, a kit comprising two transdermal therapeutic systems of the present invention as well as a method for the preparation of the transdermal therapeutic system of the present invention. In addition, the present invention relates to a transdermal therapeutic system comprising rotigotine as active ingredient for use in the treatment of patients suffering from Parkinson's disease, Parkinson's plus syndrome, depression, fibromyalgia and the restless-legs syndrome and for use in the treatment or prevention of dopaminergic neuron loss or cognitive disorders by transdermal administration of rotigotine once or twice weekly, wherein the transdermal therapeutic system comprises a backing layer, a solvent -based rotigotine containing self-adhesive matrix layer as well as a release liner and is adapted to allow for the transdermal administration of therapeutically effective amounts of rotigotine for at least 3 days.

    MULTI-DAY PATCH FOR THE TRANSDERMAL ADMINISTRATION OF ROTIGOTINE
    2.
    发明授权
    MULTI-DAY PATCH FOR THE TRANSDERMAL ADMINISTRATION OF ROTIGOTINE 有权
    ROTIGOTINE TRANSDERMAL管理的多日补丁

    公开(公告)号：EP2922533B1

    公开(公告)日：2017-06-14

    申请号：EP13795432.7

    申请日：2013-11-21

    申请人： UCB Biopharma SPRL ,  LTS LOHMANN Therapie-Systeme AG

    发明人： CAWELLO, Willi ,  LAPPERT, Aurelia ,  KASSNER, Kristina ,  WOLFF, Hans-Michael ,  MÜLLER, Walter ,  LEONHARD, Johannes Josef ,  EMGENBROICH, Marco

    IPC分类号： A61K9/70 ,  A61K31/381

    CPC分类号： A61K9/7092 ,  A61K9/7069 ,  A61K9/7084 ,  A61K31/381 ,  B32B37/12 ,  B32B2556/00

    摘要： The present invention relates to a transdermal therapeutic system, comprising (a) a backing layer, (b) a solvent-based self-adhesive matrix layer containing rotigotine as active ingredient, and (c) a release liner, wherein the self-adhesive matrix layer has a coating weight of about 75-400 g/m2 and comprises a reservoir layer containing about 9-25 wt.-% rotigotine based on the weight of the reservoir layer, a kit comprising two transdermal therapeutic systems of the present invention as well as a method for the preparation of the transdermal therapeutic system of the present invention. In addition, the present invention relates to a transdermal therapeutic system comprising rotigotine as active ingredient for use in the treatment of patients suffering from Parkinson's disease, Parkinson's plus syndrome, depression, fibromyalgia and the restless-legs syndrome and for use in the treatment or prevention of dopaminergic neuron loss or cognitive disorders by transdermal administration of rotigotine once or twice weekly, wherein the transdermal therapeutic system comprises a backing layer, a solvent-based rotigotine containing self-adhesive matrix layer as well as a release liner and is adapted to allow for the transdermal administration of therapeutically effective amounts of rotigotine for at least 3 days.

    摘要翻译： 本发明涉及透皮治疗系统，其包含（a）背衬层，（b）含有罗替戈汀作为活性成分的基于溶剂的自粘基质层，和（c）剥离衬垫，其中自粘基质 层具有约75-400g / m 2的涂层重量并且包含基于储库层的重量含有约9-25重量％罗替戈汀的储库层，包含本发明的两种透皮治疗系统的试剂盒 作为制备本发明的经皮治疗系统的方法。 另外，本发明涉及包含罗替戈汀作为活性成分的透皮治疗系统，用于治疗患有帕金森病，帕金森综合征，抑郁症，纤维肌痛和不安腿综合征的患者，并用于治疗或预防 的多巴胺能神经元丢失或认知障碍，其中透皮施用罗替戈汀每周一次或两次，其中透皮治疗系统包括背层，基于溶剂的罗替戈汀含有自粘基质层以及释放衬里，并且适于允许 经皮给药治疗有效量的罗替戈汀至少3天。