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公开(公告)号：EP3560953A1
公开(公告)日：2019-10-30
申请号：EP19172397.2
申请日：2015-12-23
申请人： UCL Business PLC , Autolus Limited
发明人： PULÉ, Martin , CORDOBA, Shaun , ONUOHA, Shimobi , THOMAS, Simon
IPC分类号： C07K14/705 , C07K16/28 , C07K16/30 , C12N5/0783
摘要： The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising an antigen-binding domain, wherein the antigen-binding domain of the first CAR binds to CD19 and the antigen-binding domain of the second CAR binds to CD22.
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公开(公告)号：EP3237442B1
公开(公告)日：2019-07-10
申请号：EP15817520.8
申请日：2015-12-23
申请人： UCL Business PLC , Autolus Limited
发明人： PULÉ, Martin , CORDOBA, Shaun , ONUOHA, Shimobi , THOMAS, Simon
IPC分类号： C07K14/705 , C07K16/28 , C07K16/30 , C12N5/0783
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公开(公告)号：EP3237442A1
公开(公告)日：2017-11-01
申请号：EP15817520.8
申请日：2015-12-23
申请人： UCL Business PLC , Autolus Limited
发明人： PULÉ, Martin , CORDOBA, Shaun , ONUOHA, Shimobi , THOMAS, Simon
IPC分类号： C07K14/705 , C07K16/28 , C07K16/30 , C12N5/0783
CPC分类号： C07K14/70521 , A61K35/00 , A61K35/17 , A61K38/1774 , A61K39/0011 , A61K2039/505 , A61K2039/5158 , C07K14/7051 , C07K14/70535 , C07K16/2803 , C07K16/2863 , C07K16/3061 , C07K2317/31 , C07K2317/622 , C07K2319/03 , C07K2319/74 , C12N5/0636 , C12N5/0638 , C12N2501/505 , C12N2501/599 , C12N2510/02
摘要： The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising an antigen-binding domain, wherein the antigen-binding domain of the first CAR binds to CD19 and the antigen-binding domain of the second CAR binds to CD22.
摘要翻译： 本发明提供了在细胞表面共表达第一嵌合抗原受体（CAR）和第二CAR的细胞，每个CAR包含抗原结合结构域，其中第一CAR的抗原结合结构域与CD19结合并且 第二种CAR的抗原结合结构域结合CD22。
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公开(公告)号：EP3114147B1
公开(公告)日：2018-04-18
申请号：EP15709320.4
申请日：2015-03-06
申请人： UCL Business Plc.
发明人： PULÉ, Martin , ANDERSON, John , THOMAS, Simon
IPC分类号： C07K19/00 , A61K39/395 , A61P35/00 , C12N15/13 , C07K16/30 , C07K14/00 , C07K14/705 , C07K14/725
CPC分类号： C07K16/3084 , A61K35/17 , A61K38/1774 , A61K38/179 , A61K39/39558 , A61K2039/505 , C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K14/70578 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/53 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/03 , C07K2319/20 , C07K2319/30 , C12N15/85 , C12N2510/00
摘要： Provision of a chimeric antigen receptor (CAR) comprising a disialoganglioside (GD2)-binding domain which comprises a) a heavy chain variable region (VH) having complementarity determining regions (CDRs) with the following sequences: b) a light chain variable region (VL) having CDRs with the following sequences: T cells expressing such a CDR are useful in the treatment of some cancers.
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公开(公告)号：EP3114147A1
公开(公告)日：2017-01-11
申请号：EP15709320.4
申请日：2015-03-06
申请人： UCL Business Plc.
发明人： PULÉ, Martin , ANDERSON, John , THOMAS, Simon
IPC分类号： C07K19/00 , A61K39/395 , A61P35/00 , C12N15/13 , C07K16/30 , C07K14/00 , C07K14/705 , C07K14/725
CPC分类号： C07K16/3084 , A61K35/17 , A61K38/1774 , A61K38/179 , A61K39/39558 , A61K2039/505 , C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K14/70578 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/53 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/03 , C07K2319/20 , C07K2319/30 , C12N15/85 , C12N2510/00
摘要： Provision of a chimeric antigen receptor (CAR) comprising a disialoganglioside (GD2)-binding domain which comprises a) a heavy chain variable region (VH) having complementarity determining regions (CDRs) with the following sequences: b) a light chain variable region (VL) having CDRs with the following sequences: T cells expressing such a CDR are useful in the treatment of some cancers.
摘要翻译： 提供包含二唾液酸神经节苷脂（GD2）结合结构域的嵌合抗原受体（CAR），其包含a）具有以下序列的互补决定区（CDR）的重链可变区（VH）：b）轻链可变区 VL）具有以下序列的CDR：表达这种CAR的T细胞可用于治疗某些癌症。
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公开(公告)号：EP3241851A1
公开(公告)日：2017-11-08
申请号：EP17160533.0
申请日：2015-03-06
申请人： UCL Business PLC
发明人： PULÉ, Martin , ANDERSON, John , THOMAS, Simon
IPC分类号： C07K19/00 , A61K39/395 , A61P35/00 , C12N15/13 , C07K16/30 , C07K14/00 , C07K14/705 , C07K14/725
CPC分类号： C07K16/3084 , A61K35/17 , A61K38/1774 , A61K38/179 , A61K39/39558 , A61K2039/505 , C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K14/70578 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/53 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/03 , C07K2319/20 , C07K2319/30 , C12N15/85 , C12N2510/00
摘要： Provision of a chimeric antigen receptor (CAR) comprising a disialoganglioside (GD2)-binding domain which comprises
a) a heavy chain variable region (VH) having complementarity determining regions (CDRs) with the following sequences:
b) a light chain variable region (VL) having CDRs with the following sequences: T cells expressing such a CDR are useful in the treatment of some cancers.摘要翻译： 提供包含唾液酸神经节苷脂（GD2）结合结构域的嵌合抗原受体（CAR），其包含a）具有互补决定区（CDR）的重链可变区（VH），其具有以下序列：b）轻链可变区 VL）具有以下序列的CDR：表达这种CDR的T细胞可用于治疗一些癌症。
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公开(公告)号：EP3553091A1
公开(公告)日：2019-10-16
申请号：EP19167976.0
申请日：2015-03-06
申请人： UCL Business PLC
发明人： PULÉ, Martin , ANDERSON, John , THOMAS, Simon
IPC分类号： C07K19/00 , A61K39/395 , A61P35/00 , C12N15/13 , C07K16/30 , C07K14/00 , C07K14/705 , C07K14/725
摘要： Provision of a method for making a GD2-expressing cell which comprises the step of introducing a nucleic acid encoding GM3 synthase and a nucleic acid encoding GD2 synthase into a cell.
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公开(公告)号：EP3303568A1
公开(公告)日：2018-04-11
申请号：EP16726416.7
申请日：2016-05-31
申请人： UCL Business PLC
发明人： PULÉ, Martin , CORDOBA, Shaun , THOMAS, Simon , KONG, Khai
IPC分类号： C12N5/0783 , C12N15/63 , C07K14/725
CPC分类号： C07K14/7051 , A61K2039/5156 , A61K2039/5158 , A61P35/00 , C07K16/2803 , C07K16/2809 , C07K16/2815 , C07K16/2818 , C07K2317/622 , C07K2319/02 , C07K2319/033 , C12N5/0636 , C12N15/867 , C12N2501/998 , C12N2510/00
摘要： The present invention relates to a cell which comprises a chimeric antigen receptor (CAR) and a signal transduction modifying protein, selected from one of the following: (i) a truncated protein which comprises an SH2 domain from a protein which binds a phosphorylated immunoreceptor tyrosine-based activation motif (ITAM), but lacks a kinase domain; (ii) a truncated protein which comprises an SH2 domain from a protein which binds a phosphorylated immunoreceptor tyrosine-based inhibition motif (ITIM) but lacks a phosphatase domain; (iii) a fusion protein which comprises (a) an SH2 domain from a protein which binds a phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) or from a protein which binds a phosphorylated immunoreceptor tyrosine-based inhibition motif (ITIM); and (ii) a heterologous domain.
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公开(公告)号：EP4368704A3
公开(公告)日：2024-05-29
申请号：EP23217769.1
申请日：2015-12-23
申请人： Autolus Limited
发明人： PULÉ, Martin , CORDOBA, Shaun , ONUOHA, Shimobi , THOMAS, Simon
IPC分类号： C07K14/705 , C07K16/28 , C07K16/30 , C12N5/0783
CPC分类号： C12N5/0636 , C12N2510/0220130101 , C07K14/7051 , C07K16/2803 , A61K2039/50520130101 , C07K2317/3120130101 , C07K2317/62220130101 , C07K2319/0320130101 , A61K35/00 , C07K14/70521 , A61K38/1774 , A61P35/00 , C12N5/0638 , A61K39/4611 , A61K39/4631 , A61K39/464412 , A61K39/464413
摘要： The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising an antigen-binding domain, wherein the antigen-binding domain of the first CAR binds to CD19 and the antigen-binding domain of the second CAR binds to CD22.
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