公开(公告)号：EP0902839A4

公开(公告)日：2004-06-30

申请号：EP97903962

申请日：1997-01-27

申请人： UNIV CALIFORNIA

发明人： CARRERA CARLOS J ,  CARSON DENNIS A ,  COTTAM HOWARD B ,  NOBORI TSUTOMU

IPC分类号： C12N15/09 ,  A61K31/00 ,  A61K31/195 ,  A61K31/198 ,  A61K45/00 ,  A61P35/00 ,  C07H21/04 ,  C07K7/06 ,  C07K7/08 ,  C07K16/40 ,  C12N1/21 ,  C12N5/06 ,  C12N9/10 ,  C12N9/12 ,  C12N15/00 ,  C12N15/02 ,  C12P19/34 ,  C12P21/08 ,  C12Q1/00 ,  C12Q1/25 ,  C12Q1/68 ,  C12R1/19 ,  C12R1/91 ,  G01N33/50 ,  G01N33/566 ,  G01N33/573 ,  A61P35/02

CPC分类号： C07K16/40 ,  A61K31/00 ,  A61K31/195 ,  A61K31/198 ,  C12N9/1077 ,  C12Q1/25 ,  C12Q1/6886 ,  C12Q2600/106 ,  G01N33/5005 ,  G01N33/573 ,  Y10S435/963 ,  Y10S435/968 ,  Y10S435/975

公开(公告)号：EP1090291A4

公开(公告)日：2004-08-25

申请号：EP99928832

申请日：1999-06-21

申请人： UNIV CALIFORNIA

发明人： CARSON DENNIS A ,  SCHMID MATHIAS ,  CARRERA CARLOS J

IPC分类号： C12Q1/68 ,  G01N33/48

CPC分类号： C12Q1/6886 ,  C12Q2600/112

摘要： The invention provides a method for diagnosis of, and determining a prognosis for, cancer causatively associated with derangements of chromosome 9p21. Underlying the invention is the discovery that such derangements have their genesis in deletions occurring centromeric to STS 3.21, most often including breakpoints in exon 8 and/or between exons 4 and 5 of the gene which codes for methylthioadenosine phosphorylase. As the cancer and tumor development advance, deletions in 9p21 progress centromerically from the genesis point toward the gene encoding p16. Thus, the method of the invention is performed by determining whether (a) portions of the 9p21 region including and telomeric to STS 3.21 are deleted; and (b) portions of the 9p21 region centromeric to STS 3.21 are deleted; wherein a positive finding in step (a) and a negative finding in step (b) are indicative of a cancer in an early stage of tumor development and a positive finding in step (b) is indicative of a cancer in an advanced stage of tumor development.

公开(公告)号：EP1034299A4

公开(公告)日：2001-03-07

申请号：EP98953964

申请日：1998-10-23

申请人： UNIV CALIFORNIA

发明人： CARSON DENNIS A ,  COTTAM HOWARD B ,  NOBORI TSUTOMU ,  CARRERA CARLOS J

IPC分类号： C12N9/99 ,  A61K31/195 ,  A61K31/198 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/706 ,  A61K31/7064 ,  A61K45/00 ,  A61P35/00 ,  A61P35/02 ,  C07H1/00 ,  C07H17/02 ,  C07H19/04 ,  C07H19/14 ,  C07K16/40 ,  C12N9/10 ,  C12Q1/00 ,  C12Q1/02 ,  C12Q1/25 ,  C12Q1/34 ,  C12Q1/42 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/573

CPC分类号： C07K16/40 ,  C12N9/1077 ,  C12Q1/25 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  G01N33/5005 ,  G01N33/573