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公开(公告)号：EP1204412A4
公开(公告)日：2004-04-21
申请号：EP00961986
申请日：2000-07-13
申请人： UNIV CALIFORNIA
IPC分类号： A61K31/198 , A61K31/407 , A61K31/7076 , A61K45/06 , A61P35/00 , A61P35/02 , G01N33/50 , A61K31/40 , A61K31/404
CPC分类号： G01N33/5011 , A61K31/198 , A61K31/407 , A61K45/06 , Y10S514/908 , A61K2300/00
摘要： A method of treating multiple myeloma (MM) is provided comprising administering an amount of etodolac to a subject afflicted with MM that is effective to selectively reduce the viability of and/or sensitize the cancer cells to an anti-cancer agent.
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2.发明公开USES OF PHOSPHOLIPID CONJUGATES OF SYNTHETIC TLR7 AGONISTS 审中-公开VERWENDUNG VON PHOSPHOLIPID-KONJUGATEN AUS SYNTHETISCHEN TLR7-AGONISTEN
公开(公告)号：EP2563366A4
公开(公告)日：2013-11-20
申请号：EP11777689
申请日：2011-04-29
申请人： UNIV CALIFORNIA
CPC分类号： A61K39/39 , A61K31/52 , A61K31/66 , A61K39/07 , A61K47/544 , A61K2039/543 , A61K2039/55511 , A61K2039/55555 , C07F9/65616
摘要： The invention provides uses for phospholipid conjugates of TLR agonists, for instance in vaccines, and to prevent, inhibit or treat a variety of disorders including inflammation, cancer and pathogen, e.g., microbe, infection.
摘要翻译： 本发明提供TLR激动剂的磷脂缀合物例如疫苗中的用途，并且用于预防，抑制或治疗多种病症，包括炎症，癌症和病原体，例如微生物感染。
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公开(公告)号：EP1931352A4
公开(公告)日：2011-11-23
申请号：EP06813535
申请日：2006-08-21
申请人： UNIV CALIFORNIA
IPC分类号： A61K31/522 , C07D473/10
CPC分类号： C07D473/16 , C07D473/18 , C07D473/24 , C07D473/34
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4.发明公开METHOD FOR INHIBITING ADENYLOSUCCINATE SYNTHETASE ACTIVITY METHYLTHIOADENOSINE PHOSPHORYLASE DEFICIENT CELLS 失效用于抑制腺苷酸合成酶的活性在甲硫磷酸不足的细胞
公开(公告)号：EP0902839A4
公开(公告)日：2004-06-30
申请号：EP97903962
申请日：1997-01-27
申请人： UNIV CALIFORNIA
IPC分类号： C12N15/09 , A61K31/00 , A61K31/195 , A61K31/198 , A61K45/00 , A61P35/00 , C07H21/04 , C07K7/06 , C07K7/08 , C07K16/40 , C12N1/21 , C12N5/06 , C12N9/10 , C12N9/12 , C12N15/00 , C12N15/02 , C12P19/34 , C12P21/08 , C12Q1/00 , C12Q1/25 , C12Q1/68 , C12R1/19 , C12R1/91 , G01N33/50 , G01N33/566 , G01N33/573 , A61P35/02
CPC分类号： C07K16/40 , A61K31/00 , A61K31/195 , A61K31/198 , C12N9/1077 , C12Q1/25 , C12Q1/6886 , C12Q2600/106 , G01N33/5005 , G01N33/573 , Y10S435/963 , Y10S435/968 , Y10S435/975
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公开(公告)号：EP1039897A4
公开(公告)日：2002-10-02
申请号：EP98958023
申请日：1998-11-16
申请人： UNIV CALIFORNIA
发明人： CARSON DENNIS A , SHIH HSIEN C , COTTAM HOWARD B , LEONI LORENZO
IPC分类号： C07C45/74 , C07C49/747 , C07C49/755 , C07C205/45 , C07C225/22 , C07C251/44 , C07D213/50 , C07D213/89 , C07D317/70 , C07F9/38 , A61K31/35 , A61K31/335 , A61K31/36 , C07D307/77 , C07D317/48 , C07D319/08 , C07D321/10
CPC分类号： C07D213/89 , C07C45/74 , C07C49/747 , C07C49/755 , C07C205/45 , C07C225/22 , C07C251/44 , C07C2602/08 , C07C2602/10 , C07D213/50 , C07D317/70 , C07F9/3882
摘要： A new family of indanone and tetralone tubulin-binding compounds (TBs) is disclosed. Unlike classical TBs, which inhibit mitosis among affected dividing cells, the TBs of the invention possess two unique properties: (1) they induce apoptosis among stationary phase (non-dividing) malignant cells, yet do not impair the viability of normal nonproliferating cells; and, (2) they affect cells which have acquired MDR more powerfully than they affect cells without MDR. Thus, the TBs of the invention provide means to target malignant cells for chemotherapy, even after previous therapies have failed, without affecting normal cells and tissues in the host.
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公开(公告)号：EP2029597A4
公开(公告)日：2011-11-23
申请号：EP07755916
申请日：2007-04-23
申请人： UNIV CALIFORNIA
IPC分类号： C07D473/04 , A61K31/52 , A61K31/522 , A61P31/00 , A61P35/00 , A61P37/00 , C07D473/16 , C07D473/18 , C07D473/20 , C07D473/22 , C07D473/24 , C07D473/26 , C07D473/28 , C07D473/30 , C07D473/32 , C07D473/34 , C07D473/36 , C07D473/38
CPC分类号： A61K47/48046 , C07D473/18
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公开(公告)号：EP1034299A4
公开(公告)日：2001-03-07
申请号：EP98953964
申请日：1998-10-23
申请人： UNIV CALIFORNIA
IPC分类号： C12N9/99 , A61K31/195 , A61K31/198 , A61K31/7042 , A61K31/7052 , A61K31/706 , A61K31/7064 , A61K45/00 , A61P35/00 , A61P35/02 , C07H1/00 , C07H17/02 , C07H19/04 , C07H19/14 , C07K16/40 , C12N9/10 , C12Q1/00 , C12Q1/02 , C12Q1/25 , C12Q1/34 , C12Q1/42 , C12Q1/68 , G01N33/50 , G01N33/573
CPC分类号： C07K16/40 , C12N9/1077 , C12Q1/25 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , G01N33/5005 , G01N33/573
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公开(公告)号：EP0801568A4
公开(公告)日：1998-02-25
申请号：EP95944144
申请日：1995-12-18
申请人： UNIV CALIFORNIA
发明人： CARSON DENNIS A , COTTAM HOWARD B , WASSON D BRUCE
IPC分类号： A61K31/47 , A61K31/472 , A61K31/505 , A61K31/519 , A61K31/52 , A61K31/522 , A61P17/00 , A61P29/00 , A61P43/00 , C07D217/24 , C07D239/96 , C07D473/04 , C07D473/06 , C07D473/10 , C07D475/02 , C07D487/04 , C07D513/04
CPC分类号： C07D513/04 , C07D217/24 , C07D239/96 , C07D473/06 , C07D473/10 , C07D475/02
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