公开(公告)号：EP2925340A4

公开(公告)日：2017-01-04

申请号：EP13857618

申请日：2013-11-20

申请人： UNIV CINCINNATI ,  ABDEL-MALEK ZALFA A ,  KOIKOV LEONID ,  KNITTEL JAMES J

发明人： ABDEL-MALEK ZALFA A ,  KOIKOV LEONID ,  KNITTEL JAMES J

IPC分类号： A61K38/34 ,  A61K8/64 ,  A61K38/00 ,  A61K38/06 ,  A61K38/07 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/04 ,  A61Q19/08 ,  C07K5/097 ,  C07K5/117

CPC分类号： C07K5/1024 ,  A61K8/06 ,  A61K8/64 ,  A61K9/0014 ,  A61K38/00 ,  A61K38/06 ,  A61K38/07 ,  A61Q17/04 ,  A61Q19/004 ,  A61Q19/04 ,  A61Q19/08 ,  C07K5/0821

摘要： Short tri- and tetrapeptides according to the following Formula I Ar(CH2)mX1—X2—CO—X3—X4—X5-(Trp)n-NX6R are potent, selective agonists of melanocortin 1 receptor (MC1R). Provided herein are skin care compositions including Formula I peptide agonists of MC1R and methods of regulating a skin condition of a mammal that include applying to a treatment surface of the body a safe and effective amount of a skin care composition including a Formula I peptide. The peptides, skin care compositions, and skin care methods described herein are useful in regulating a skin condition of a mammal associated with exposure ultraviolet (UV) radiation, including sunburn, UV sensitivity, photoaging, and skin pigmentation, particularly in the absence of sun exposure.

公开(公告)号：EP2922565A4

公开(公告)日：2016-06-15

申请号：EP13856556

申请日：2013-11-20

申请人： UNIV CINCINNATI ,  ABDEL MALEK ZALFA A ,  KOIKOV LEONID ,  KNITTEL JAMES J

发明人： ABDEL-MALEK ZALFA A ,  KOIKOV LEONID ,  KNITTEL JAMES J

IPC分类号： A61K38/34 ,  A61K8/64 ,  A61K38/00 ,  A61K38/06 ,  A61K38/07 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/04 ,  A61Q19/08 ,  C07K5/097 ,  C07K5/117

CPC分类号： C07K5/1024 ,  A61K8/06 ,  A61K8/64 ,  A61K9/0014 ,  A61K38/00 ,  A61K38/06 ,  A61K38/07 ,  A61Q17/04 ,  A61Q19/004 ,  A61Q19/04 ,  A61Q19/08 ,  C07K5/0821

摘要： Short tri- and tetrapeptides according to the following Formula I Ar(CH2)mX1—X2—CO—X3—X4—X5-(Trp)n-NX6R are potent, selective agonists of melanocortin 1 receptor (MC1R). Provided herein are skin care compositions including Formula I peptide agonists of MC1R and methods of regulating a skin condition of a mammal that include applying to a treatment surface of the body a safe and effective amount of a skin care composition including a Formula I peptide. The peptides, skin care compositions, and skin care methods described herein are useful in regulating a skin condition of a mammal associated with exposure ultraviolet (UV) radiation, including sunburn, UV sensitivity, photoaging, and skin pigmentation, particularly in the absence of sun exposure.

摘要翻译： 根据下式I Ar（CH2）mX1-X2-CO-X3-X4-X5-（Trp）n-NX6R的短三肽和四肽是黑皮质素1受体（MC1R）的有效选择性激动剂。 本文提供包含MC1R的式I肽激动剂的护肤组合物和调节哺乳动物皮肤状况的方法，其包括向身体的治疗表面施用安全有效量的包含式I肽的护肤组合物。 本文所述的肽，皮肤护理组合物和护肤方法可用于调节与暴露于紫外线（UV）辐射相关的哺乳动物的皮肤状况，包括晒伤，UV敏感性，光老化和皮肤色素沉着，特别是在没有阳光的情况下 曝光。