公开(公告)号：EP3148430A4

公开(公告)日：2018-05-16

申请号：EP15800043

申请日：2015-05-28

申请人： UNIV CINCINNATI

发明人： HEIKENFELD JASON C

IPC分类号： A61B5/05 ,  A61B5/00 ,  A61B5/053 ,  A61B5/145 ,  A61B10/00 ,  A61N1/04 ,  A61N1/32

CPC分类号： A61B10/0064 ,  A61B5/053 ,  A61B5/0531 ,  A61B5/14517 ,  A61B5/14521 ,  A61B5/4266 ,  A61B5/6833 ,  A61B2010/0009 ,  A61B2503/045 ,  A61B2503/10 ,  A61B2503/12 ,  A61B2560/0412 ,  A61B2560/0443 ,  A61B2562/18 ,  A61N1/0428 ,  A61N1/325

摘要： A sweat sensor device (200) includes one or more sweat sensors (220) and a seal (280) covering the one or more sweat sensors (220). The seal (280) is adapted to protect the sweat sensors (220) from outside contaminants when the device (200) is placed on the skin (12). The sweat sensor device (200) may include an absorbing medium (230) to absorb sweat from the skin (12) that is covered by the seal (280). The seal (280) can be permeable to gas, permeable to water and impermeable to at least one aqueous solute, or selectively permeable to at least one aqueous solute. The sweat sensor device (200) may include an artificial sweat stimulation mechanism (345) for stimulating sweat when the device (200) is placed on the skin (12).

公开(公告)号：EP3286305A2

公开(公告)日：2018-02-28

申请号：EP16784068

申请日：2016-04-25

申请人： UNIV CINCINNATI

发明人： ADDEPALLI BALASUBRAHMANYAM ,  LESSNER NICHOLAS PAUL ,  LIMBACH PATRICK ALAN ,  VENUS SARAH

IPC分类号： C12N9/22 ,  C07H21/04 ,  C07K14/00 ,  C12P21/06 ,  C12Q1/68

CPC分类号： C12N9/22 ,  C12Q1/6869 ,  C12Q2521/327

摘要： A recombinant ribonuclease is disclosed. The recombinant ribonuclease is produced by introducing a recombinant DNA sequence into a host; activating expression of the recombinant DNA sequence within the host to produce the recombinant ribonuclease; and isolating the recombinant ribonuclease from the host. Additionally, a method of analyzing an RNA sequence includes digesting the RNA with a first recombinant ribonuclease to give digestion products comprising nucleotides of the RNA sequence; and analyzing the digestion products using an analytical method to provide the identity of at least some of the nucleotides. The recombinant ribonuclease includes at least one of a uridine-specific recombinant RNase MCI and a cytidine-specific recombinant RNase Cusativin.

公开(公告)号：EP3148415A4

公开(公告)日：2018-01-24

申请号：EP15799317

申请日：2015-05-28

申请人： UNIV CINCINNATI

发明人： HEIKENFELD JASON C

IPC分类号： A61B5/00 ,  A61B5/145 ,  A61B5/1477 ,  G01N33/487

CPC分类号： A61B5/14517 ,  A61B5/1468 ,  A61B5/1477 ,  A61B5/4266 ,  A61B5/441 ,  A61B5/6802 ,  A61B5/6833 ,  G01N33/48721

摘要： An electronic sweat sensor (300) includes a plurality of porous substrates (310, 312), each porous substrate (310, 312) having an electrically conductive surface (320, 322). The porous substrates (310, 312) have a generally planar surface. The generally planar surface may be adapted to be positioned on skin (12) generally coplanar with the skin. The electronic sweat sensor (300) further includes a porous spacer (315) layer defining a gap between at least two of the porous substrates (310, 312). When an analyte flow (305), which may be from skin (12), is moving perpendicular to the planar surface and through at least one of the porous substrates (310, 312), at least one of the conductive surfaces (320, 322) provides an electrical response to the presence of the analyte flow (305).

公开(公告)号：EP2465007A4

公开(公告)日：2017-01-11

申请号：EP10808825

申请日：2010-08-13

申请人： UNIV CINCINNATI

发明人： HEIKENFELD JASON ,  KREIT ERIC ,  YANG SHU

IPC分类号： C25B9/00 ,  G02B26/00

CPC分类号： B01L3/502792 ,  B01L3/502715 ,  G02B26/004

公开(公告)号：EP2925340A4

公开(公告)日：2017-01-04

申请号：EP13857618

申请日：2013-11-20

申请人： UNIV CINCINNATI ,  ABDEL-MALEK ZALFA A ,  KOIKOV LEONID ,  KNITTEL JAMES J

发明人： ABDEL-MALEK ZALFA A ,  KOIKOV LEONID ,  KNITTEL JAMES J

IPC分类号： A61K38/34 ,  A61K8/64 ,  A61K38/00 ,  A61K38/06 ,  A61K38/07 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/04 ,  A61Q19/08 ,  C07K5/097 ,  C07K5/117

CPC分类号： C07K5/1024 ,  A61K8/06 ,  A61K8/64 ,  A61K9/0014 ,  A61K38/00 ,  A61K38/06 ,  A61K38/07 ,  A61Q17/04 ,  A61Q19/004 ,  A61Q19/04 ,  A61Q19/08 ,  C07K5/0821

摘要： Short tri- and tetrapeptides according to the following Formula I Ar(CH2)mX1—X2—CO—X3—X4—X5-(Trp)n-NX6R are potent, selective agonists of melanocortin 1 receptor (MC1R). Provided herein are skin care compositions including Formula I peptide agonists of MC1R and methods of regulating a skin condition of a mammal that include applying to a treatment surface of the body a safe and effective amount of a skin care composition including a Formula I peptide. The peptides, skin care compositions, and skin care methods described herein are useful in regulating a skin condition of a mammal associated with exposure ultraviolet (UV) radiation, including sunburn, UV sensitivity, photoaging, and skin pigmentation, particularly in the absence of sun exposure.

公开(公告)号：EP2819993A4

公开(公告)日：2016-01-20

申请号：EP13755719

申请日：2013-03-01

申请人： UNIV CINCINNATI ,  CINCINNATI CHILDREN S HOSPITAL MEDICAL CT

发明人： MERINO EDWARD J ,  MULLOY JAMES C ,  LI GUORUI ,  BELL-HORWATH TIFFANY

IPC分类号： C07C229/00 ,  A01N43/40 ,  A61K31/138 ,  A61K31/145 ,  A61K31/167 ,  A61K31/196 ,  A61K31/215 ,  A61K31/216 ,  A61K31/451 ,  A61K45/06 ,  C07C217/20 ,  C07C217/84 ,  C07C233/25 ,  C07C237/04 ,  C07C237/08 ,  C07C273/00 ,  C07C323/25 ,  C07D295/096

CPC分类号： C07C217/20 ,  A61K31/138 ,  A61K31/145 ,  A61K31/167 ,  A61K31/196 ,  A61K31/215 ,  A61K31/216 ,  A61K31/451 ,  A61K45/06 ,  C07C217/84 ,  C07C229/42 ,  C07C233/25 ,  C07C237/04 ,  C07C237/08 ,  C07C321/28 ,  C07C323/25 ,  C07D295/096 ,  A61K2300/00

摘要： Provided are compounds according to the following Formula I: The Formula I compounds are activated in the presence of reactive oxygen species (ROS) and are therefore selective anti-cancer therapeutics for cancers associated with elevated ROS. Also provided are methods and pharmaceutical compositions for treating cancers associated with increased ROS.

摘要翻译： 提供根据下式I的化合物：式I化合物在活性氧（ROS）存在下活化，因此是与升高的ROS相关的癌症的选择性抗癌治疗剂。 还提供了用于治疗与增加的ROS相关的癌症的方法和药物组合物。

公开(公告)号：EP1774391A4

公开(公告)日：2009-11-04

申请号：EP05769337

申请日：2005-07-08

申请人： UNIV CINCINNATI

发明人： STECKL ANDREW J ,  HEIKENFELD JASON C

IPC分类号： G02B26/02

CPC分类号： G02B26/004 ,  G02B5/02

公开(公告)号：EP1169483A4

公开(公告)日：2003-03-12

申请号：EP00980212

申请日：2000-03-10

申请人： UNIV CINCINNATI

发明人： LIGGETT STEPHEN B

IPC分类号： C07K14/705 ,  C12Q1/68

CPC分类号： C07K14/70571 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156

摘要： A method for predicting an individual's response to the ss-agonists salmeterol, albuterol, metaproterenol, terbutaline and formoterol is disclosed. Individuals expressing the Ile164 ss2AR variant are likely to exhibit a reduced response as compared to individuals expressing the Thr164 ss2AR variant. The method is useful for making treatment decisions for patients suffering from asthma and chronic obstructive pulmonary diseases.

公开(公告)号：EP0692971A4

公开(公告)日：1997-11-12

申请号：EP94913965

申请日：1994-03-29

申请人： UNIV CINCINNATI

发明人： BALASUBRAMANIAM AMBIKAIPAKAN

IPC分类号： A61K38/00 ,  A61P1/00 ,  A61P3/00 ,  A61P3/12 ,  C07K7/06 ,  C07K14/575 ,  A61K38/17 ,  C07K5/00 ,  C07K7/00 ,  C07K14/47 ,  C07K17/00

CPC分类号： C07K14/575 ,  A61K38/00 ,  C07K14/57545

公开(公告)号：EP0590060A4

公开(公告)日：1994-05-25

申请号：EP92914240

申请日：1992-06-11

申请人： UNIV CINCINNATI

发明人： MICHAEL JACOB G

IPC分类号： A61K9/50 ,  A61K9/52 ,  A61K38/00 ,  A61K38/17 ,  A61K38/39 ,  A61K38/48 ,  A61K39/00 ,  A61K39/12 ,  A61K39/35 ,  A61K39/39 ,  A61K47/42 ,  A61P37/08

CPC分类号： A61K36/28 ,  A61K9/5078 ,  A61K39/35 ,  A61K47/42 ,  A61K2039/542 ,  A61K2039/55505 ,  A61K2039/55555 ,  Y10S514/825

摘要： An orally administrable therapeutic protein is provided by combining the therapeutic protein with a stabilizing agent in an aqueous solution. The solution is coated onto nonpareils and microencapsulated with a water emulsifiable enteric coating composition. The microcapsules are orally administered. The coating protects the protein as it passes through the stomach. Upon reaching the small intestines, the basic pH of the intestinal juices will dissolve the coating, allowing the protein to be released and induce antigen specific immune response which has the specificity of the native molecule. The stabilizing agent protects the therapeutic protein from denaturation during the encapsulation process.