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公开(公告)号：EP2318430A4
公开(公告)日：2012-08-29
申请号：EP09806982
申请日：2009-08-14
发明人： KORBER BETTE T , FISCHER WILLIAM , LETVIN NORMAN , LIAO HUA-XIN , HAYNES BARTON F , HAHN BEATRICE H
IPC分类号： C07K14/155 , A61K39/21 , C12N15/49
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2710/24143 , C12N2740/16022 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16234 , C12N2740/16334
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公开(公告)号：EP1917040A4
公开(公告)日：2012-12-12
申请号：EP06802155
申请日：2006-08-23
发明人： KORBER BETTE T , PERKINS SIMON , BHATTACHARYA TANMOY , FISCHER WILLIAM M , THEILER JAMES , LETVIN NORMAN , HAYNES BARTON F , HAHN BEATRICE H , YUSIM KARINA , KUIKEN CARLA
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , C12N2740/16034
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3.发明公开CAP260, CAP174 AND K0224 HIV-1 ENVELOPES, PEPTIDE AND COMPOSITIONS 审中-公开CAP260-，CAP174- UND K0224-HIV-1信封，肽和佐剂明胶
公开(公告)号：EP3083661A4
公开(公告)日：2017-06-28
申请号：EP14870945
申请日：2014-12-18
发明人： HAYNES BARTON F , KORBER BETTE T
IPC分类号： C07K14/155 , A61K39/00 , A61K39/12 , A61K39/21 , A61K39/295 , A61K39/39 , C07K14/005 , C12N7/00 , C12N15/49 , C12N15/63 , C12N15/863
CPC分类号： A61K39/21 , A61K39/12 , A61K39/295 , A61K39/39 , A61K2039/545 , A61K2039/55566 , A61K2039/575 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171
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公开(公告)号：EP3119890A4
公开(公告)日：2017-12-27
申请号：EP15764507
申请日：2015-03-19
发明人： HAYNES BARTON F , GAO FENG , KORBER BETTE T , HRABER PETER T
IPC分类号： C12N15/46 , A61K39/21 , C07K14/155 , C12N15/85
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2710/24143 , C12N2740/16134
摘要： In certain aspects the invention provides HIV-1 immunogens, including envelopes (CH505) and selections therefrom, and methods for swarm immunizations using combinations of HIV-1 envelopes.
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公开(公告)号：EP3126502A4
公开(公告)日：2018-01-17
申请号：EP15772335
申请日：2015-03-31
IPC分类号： C12N15/49 , A61K31/7088 , A61K39/21 , C07K14/155
CPC分类号： A61K31/7088 , A61K39/12 , A61K39/21 , A61K2039/70 , C07K14/155 , C12N2740/16034
摘要： In certain aspects the invention provides immonogenic compositions comprising CH848 HIV-1 envelopes and their use in methods to induce immune responses in subjects, e.g., human subjects.
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公开(公告)号：EP2895500A4
公开(公告)日：2016-04-13
申请号：EP13837551
申请日：2013-09-12
申请人： UNIV DUKE , LOS ALAMOS NAT SECURITY LLC , UNIV PENNSYLVANIA , UNIV BOSTON , US GOV HEALTH & HUMAN SERV , UNIV LELAND STANFORD JUNIOR
发明人： HAYNES BARTON F , LIAO HUA-XIN , LYNCH REBECCA M , ZHOU TONGQING , GAO FENG , BOYD SCOTT , SHAW GEORGE M , HAHN BEATRICE H , KEPLER THOMAS B , KORBER BETTE T , KWONG PETER , MASCOLA JOHN
IPC分类号： C07K14/155 , A61K39/12 , A61P31/18
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/57 , C07K14/005 , C12N7/00 , C12N2740/15022 , C12N2740/16022 , C12N2740/16122 , C12N2740/16134
摘要： The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the production of broadly neutralizing HIV-1 antibodies in a subject (e.g., a human).
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公开(公告)号：EP3197488A4
公开(公告)日：2018-03-21
申请号：EP15843595
申请日：2015-09-25
发明人： HAYNES BARTON F , LIAO HUA XIN , KORBER BETTE T , HRABER PETER T
IPC分类号： A61K39/21
CPC分类号： A61K39/21 , A61K31/4706 , A61K39/12 , A61K39/3955 , A61K47/48276 , A61K47/4833 , A61K47/48338 , A61K47/48815 , A61K2039/505 , A61K2039/545 , A61K2039/6018 , A61K2039/627 , C07K14/70578 , C07K2319/70 , C12N7/00 , C12N2740/16134
摘要： In certain aspects the invention provides a selection of HIV-1 envelopes suitable for use as immunogens, and methods of using these immunogens to induce neutralizing antibodies. In certain embodiments, the immunogens are designed to trimerize. In other embodiments, the immunogens comprise an immune modulating component.
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公开(公告)号：EP3122881A4
公开(公告)日：2017-11-15
申请号：EP15769306
申请日：2015-03-25
发明人： HAYNES BARTON F , KORBER BETTE T
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/70 , C12N2740/16034 , C12N2740/16134 , C12N2740/16234 , C12N2740/16334
摘要： The invention is directed to mosaic HIV 1 genes designed to induce T-cell responses.
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公开(公告)号：EP2986628A4
公开(公告)日：2016-09-21
申请号：EP14785257
申请日：2014-04-15
申请人： UNIV DUKE , GOVERNMENT OF THE US AS REPRESENTED BY THE SECRETARY OF THE ARMY ON BEHALF OF WALTER REED ARMY INST , JACKSON H M FOUND MILITARY MED , LOS ALAMOS NAT SECURITY LLC
发明人： KIM JEROME , ROLLAND MORGANE , KORBER BETTE T , HAYNES BARTON F
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/70 , C12N7/00 , C12N2740/16122 , C12N2740/16134
摘要： The present invention relates, in general, to human immunodeficiency virus-1 (HIV-1) particular, to a polyvalent vaccine for HIV-1 and to methods of making and using same.
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公开(公告)号：EP1667714A4
公开(公告)日：2008-09-24
申请号：EP04784298
申请日：2004-09-17
发明人： HAYNES BARTON F , GAO FENG , KORBER BETTE T , HAHN BEATRICE H , SHAW GEORGE M , KOTHE DENISE , LI YING YING , DECKER JULIE , LIAO HUA-XIN
IPC分类号： A61K39/21 , C07H21/04 , C12N20060101 , C12N5/02 , C12N15/74
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K16/4225 , C12N2740/15022 , C12N2740/15034 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16322
摘要： The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.
摘要翻译： 本发明一般涉及免疫原，特别涉及用于诱导中和大范围的HIV原代分离物和/或诱导T细胞免疫应答的免疫原的抗体的免疫原。 本发明还涉及使用这种免疫原诱导抗HIV抗体的方法和/或诱导T细胞免疫应答的方法。 本发明还涉及编码本发明免疫原的核酸序列。
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