公开(公告)号：EP0963219A4

公开(公告)日：2002-11-13

申请号：EP97938149

申请日：1997-08-13

申请人： UNIV DUKE ,  WISCONSIN MED COLLEGE INC

发明人： STAMLER JONATHAN S ,  GRIFFITH OWEN W

IPC分类号： A61K31/00 ,  A61K31/195 ,  A61K31/255 ,  C07C381/10 ,  A61N1/362 ,  A61K39/395 ,  A61K39/40 ,  A61P9/00 ,  A61P31/00 ,  A61P33/00 ,  A61P35/00 ,  G01N31/00 ,  G01N33/00 ,  G01N33/03 ,  G01N33/26 ,  G01N33/554 ,  G01N33/569 ,  G01N33/574

CPC分类号： A61K31/00 ,  A61K31/195 ,  A61K31/255 ,  C07C381/10

摘要： Mammals are treated for infections or for conditions associated with pathologically proliferating mammalian cell growth by administration of a manipulator of nitrosative stress to selectively kill or reduce the growth of the microbes or helminths causing the infection or of host cells infected with the microbes or of the pathologically proliferating mammalian cells. Novel agents include alpha-alkyl-S-alkyl-homocysteine sulfoxmines wherein the alpha-alkyl contains 2 to 8 carbon atoms, and the S-alkyl contains 1 to 10 carbon atoms. Mammals in need of increased nitrosative stress defenses are treated, e.g., humans at risk for a stroke because of having had a transient ischemic attack, are treated. Treatments to increase nitrosative stress defenses include repeated administrations of low doses of manipulators of nitrosative stress so that the subject treated has increased tolerance to nitrosative stress. Mammals are treated for protozoal infections by systemic administration of L-buthionine-S-sulfoximine and agent that increases nitrosative stress.

公开(公告)号：EP0707577A4

公开(公告)日：1996-11-06

申请号：EP94916576

申请日：1994-05-06

申请人： WISCONSIN MED COLLEGE INC

发明人： GRIFFITH OWEN W ,  NARAYANAN KRISHNASWAMY

IPC分类号： C07D333/20 ,  A61K31/18 ,  A61K31/195 ,  A61K31/198 ,  A61P9/00 ,  A61P25/00 ,  A61P37/06 ,  A61P43/00 ,  C07C281/16 ,  C07C323/25 ,  C07C335/04 ,  C07C335/08 ,  C07D233/64 ,  C07D333/22 ,  A61K31/155 ,  A61K31/17 ,  A61K31/38 ,  C07C257/14 ,  C07C279/04 ,  C07C335/02

CPC分类号： C07C335/08 ,  C07D333/22

公开(公告)号：EP1244460A4

公开(公告)日：2004-10-06

申请号：EP00975204

申请日：2000-10-23

申请人： UNIV DUKE ,  CORNELL RES FOUNDATION INC

发明人： STAMLER JONATHAN S ,  DAY BRIAN J ,  GRIFFITH OWEN W ,  GROSS STEVEN S

IPC分类号： A61K31/00 ,  A61K31/223 ,  A61K31/44 ,  A61K31/4425 ,  A61K31/444 ,  A61K31/4985 ,  A61K33/00 ,  A61K31/24 ,  A61K31/495 ,  A61K31/70 ,  A61P9/10 ,  A61P9/12 ,  A61P13/08 ,  A61P35/00

CPC分类号： A61K31/44 ,  A61K31/00 ,  A61K31/223 ,  A61K31/4425 ,  A61K31/444 ,  A61K31/4985 ,  A61K33/00 ,  A61K31/22 ,  A61K2300/00