公开(公告)号：EP1941031A4

公开(公告)日：2009-06-10

申请号：EP06825367

申请日：2006-10-03

申请人： UNIV ILLINOIS ,  ZHAO YONG ,  MAZZONE THEODORE

发明人： ZHAO YONG ,  MAZZONE THEODORE

IPC分类号： C12N5/074 ,  C12N5/0783

CPC分类号： C12N5/0607 ,  A61K2035/122 ,  C12N5/0636 ,  C12N2501/23 ,  C12N2501/59 ,  C12N2502/03

公开(公告)号：EP2510084A4

公开(公告)日：2015-04-08

申请号：EP10843462

申请日：2010-12-08

申请人： UNIV ILLINOIS

发明人： ZHAO YONG

IPC分类号： C12M3/00 ,  A61K35/12 ,  A61K35/26 ,  A61P37/00 ,  C12M1/12 ,  C12M1/34 ,  C12M1/42 ,  C12N5/0735 ,  C12N5/078 ,  C12N5/0783

CPC分类号： A61M1/3489 ,  A61K2035/122 ,  A61M1/3472 ,  A61M2202/0407 ,  C12M25/08 ,  C12M35/08 ,  C12N5/0634 ,  C12N2502/11

摘要： Methods and apparatus are disclosed co-culturing stem cells with mononuclear cells and/or lymphocytes to modulate their function. The invention also discloses the use of stem cells to educate autoreactive immune cells as a mechanism to treat autoimmune diseases and immune disorder-related diseases, such as diabetes. In one aspect of the invention, bioreactors are disclosed closed for modulating lymphocytes and suppressing autoreactive T cells. The bioreactors can include a chamber having at least one positively charged and/or hydrophobic substrate surface, a population of stem cells attached to the substrate surface, an inlet conduit for introducing lymphocytes into the chamber, and an outlet conduit for extracting treated lymphocytes following co-culturing with the stem cells.