公开(公告)号：EP1093515A4

公开(公告)日：2007-05-02

申请号：EP99928478

申请日：1999-06-08

申请人： UNIV SOUTH FLORIDA

发明人： JAROSZESKI MARK J ,  GILBERT RICHARD A ,  HELLER RICHARD

IPC分类号： C12M3/00 ,  C12N5/16 ,  C12N13/00

CPC分类号： C12N13/00 ,  C12M35/02

摘要： An apparatus is provided for producing cell electrofusion (20) wherein the cells to be fused are directed to and retained on one side of a substrate (34) and between the electrodes (30, 32). Thus, a significant portion of the cells are in close cell-to-cell contact so that dielectrophoresis is not needed before electrofusion. In a preferred embodiment, the substrate is porous (34) and the cells are held onto the porous substrate by means of a vacuum (38).

公开(公告)号：EP0814819A4

公开(公告)日：2001-05-02

申请号：EP96908759

申请日：1996-03-12

申请人： UNIV SOUTH FLORIDA

发明人： SANBERG PAUL R ,  CAMERON DON F ,  BORLONGAN CESARIO V ,  HELLER RICHARD

IPC分类号： A61K35/12 ,  A61K35/30 ,  A61K35/48 ,  C12N5/071 ,  A61K35/00 ,  A01N63/00 ,  C12N5/06

CPC分类号： C12N5/0683 ,  A61K35/12 ,  A61K35/30 ,  A61K35/48 ,  A61K2035/122 ,  C12N5/0618 ,  C12N2502/246

摘要： A method of producing a sustained localized immunosuppressive effect in localized tissues is achieved by transplanting Sertoli cells proximate to the tissue.

公开(公告)号：EP1301584A4

公开(公告)日：2004-08-04

申请号：EP01912789

申请日：2001-02-16

申请人： UNIV SOUTH FLORIDA

发明人： JAROSZESKI MARK J ,  GILBERT RICHARD A ,  HELLER RICHARD

IPC分类号： C12M1/42 ,  C12M3/00 ,  C12N13/00 ,  C12N15/02

CPC分类号： C12N13/00 ,  C12M35/02 ,  C12N15/02

摘要： A new and useful apparatus for producing cell electrofusion is provided. The apparatus comprises: a. a chamber with a substrate disposed therein; b. means for directing the cells to be fused toward one side of the substrate; and c. a device for inducing fusion of the portion of the cells.

摘要翻译： 提供了一种用于生产细胞电融合的新型有用的装置。 该装置包括：a。 一个具有衬底的腔室，b。 用于引导所述细胞被熔化到所述基底的一侧的装置; 和c。 用于诱导细胞部分融合的装置。