公开(公告)号：EP2702135A4

公开(公告)日：2015-01-28

申请号：EP12776772

申请日：2012-04-27

申请人： UNIV SOUTHERN CALIFORNIA

发明人： ZHU DANHONG ,  HINTON DAVID ,  AHUJA ASHISH ,  HUMAYUN MARK

IPC分类号： A01N1/02

CPC分类号： A01N1/0252 ,  A01N1/0268 ,  A01N1/0284 ,  A61L27/16 ,  A61L27/34 ,  A61L27/3813 ,  A61L27/3834 ,  A61L27/58 ,  C12N5/0621

摘要： Disclosed herein are methods and compositions for the cryopreservation of stem cells, such as stem-cell derived retinal pigment epithelial cells, that have been seeded onto and cultured on a substrate, such as a polymeric substrate. Such cryopreserved stem cells are useful for cell therapies, such as treatment of ocular damage or disease.

公开(公告)号：EP2593117A4

公开(公告)日：2014-01-15

申请号：EP11807411

申请日：2011-07-12

申请人： UNIV SOUTHERN CALIFORNIA ,  CALIFORNIA INST OF TECHN ,  UNIV CALIFORNIA AT SANTA BARBARA

发明人： HUMAYUN MARK ,  AHUJA ASHISH ,  TAI YU-CHONG ,  HINTON DAVID ,  GRUBBS ROBERT ,  CLEGG DENNIS ,  JOHNSON LINCOLN VALLANCE ,  HIKITA SHERRY T

IPC分类号： A61K35/54 ,  A61F2/14 ,  A61K35/44 ,  A61L27/38 ,  B32B3/00

CPC分类号： A61L27/18 ,  A61K9/0051 ,  A61K35/30 ,  A61K35/545 ,  A61K47/34 ,  A61L27/3813 ,  A61L27/3834 ,  A61L27/56 ,  A61L2430/00 ,  A61L2430/16 ,  Y10T428/24479

摘要： Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.

摘要翻译： 在本发明公开了基材细胞递送到靶组织需要治疗各种疾病并诱导细胞死亡，损伤或功能丧失。 基板被配置为提供接种的细胞，包括干细胞，具有结构支撑确实允许与互连和细胞和靶组织之间的生物信号的传输。