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1.发明公开BIOCOMPATIBLE SUBSTRATE FOR FACILITATING INTERCONNECTIONS BETWEEN STEM CELLS AND TARGET TISSUES AND METHODS FOR IMPLANTING SAME 审中-公开生物相容性基底，以促进植入干细胞和靶组织和方法之间的联系
公开(公告)号：EP2593117A4
公开(公告)日：2014-01-15
申请号：EP11807411
申请日：2011-07-12
发明人： HUMAYUN MARK , AHUJA ASHISH , TAI YU-CHONG , HINTON DAVID , GRUBBS ROBERT , CLEGG DENNIS , JOHNSON LINCOLN VALLANCE , HIKITA SHERRY T
CPC分类号： A61L27/18 , A61K9/0051 , A61K35/30 , A61K35/545 , A61K47/34 , A61L27/3813 , A61L27/3834 , A61L27/56 , A61L2430/00 , A61L2430/16 , Y10T428/24479
摘要： Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
摘要翻译： 在本发明公开了基材细胞递送到靶组织需要治疗各种疾病并诱导细胞死亡，损伤或功能丧失。 基板被配置为提供接种的细胞，包括干细胞，具有结构支撑确实允许与互连和细胞和靶组织之间的生物信号的传输。
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公开(公告)号：EP2887906A4
公开(公告)日：2016-06-08
申请号：EP13830601
申请日：2013-08-22
发明人： TAI YU-CHONG , ZHAO YU JOY , HUMAYUN MARK , WEILAND JAMES D
CPC分类号： A61F9/007 , A61F2/14 , A61F2250/0001 , A61N1/0529 , A61N1/0543 , A61N1/0551 , A61N1/36046 , A61N1/3605 , A61N1/3787 , C23F1/00 , H01F27/2804 , H01F2027/2809
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公开(公告)号：EP2713951A4
公开(公告)日：2015-04-22
申请号：EP12790087
申请日：2012-01-13
发明人： DEBOER CHARLES , TAI YU-CHONG , HUMAYUN MARK
IPC分类号： A61F2/16 , A61L27/14 , C08L101/16
CPC分类号： A61F2/1635 , A61F2/1613 , A61F9/007 , A61F2250/0003 , A61L27/48 , A61L2430/16 , C08G2261/3424 , C08L65/04
摘要： Systems, devices, and methods are presented for a prosthetic injectable intraocular lens. One or more silicone elastomeric patches located outside the optical path on the anterior side but away from the equator can be accessed by surgical needles in order to fill or adjust optically clear fluid within the lens. The fluid can be adjusted in order to set a base dioptric power of the lens and otherwise adjust a lens after its initial insertion. The elastomeric patches are sized so that they self-seal after a needle is withdrawn. A straight or stepped slit in the patch can allow a blunt needle to more easily access the interior of the lens.
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公开(公告)号：EP2459658A4
公开(公告)日：2012-12-26
申请号：EP10806850
申请日：2010-07-23
发明人： LEE CHOON WOO , GRUBBS ROBERT H , HUMAYUN MARK
CPC分类号： C09D5/14 , A01N33/12 , C08G73/0206 , C08G73/0226 , C09D5/1637 , C09D179/02 , D06M16/00 , Y10T428/31721 , Y10T428/31725 , A01N25/34 , A01N2300/00
摘要： The disclosure provides methods and materials suitable for preparing coating layers on substrates. The coatings comprise quaternary amine groups and therefore impart anti-bacterial properties to the substrate. In one embodiment, for example, there is provided a quaternary amine-containing polymeric coating comprising propylene and ethylene repeat units.
摘要翻译： 本公开提供适合于在基底上制备涂层的方法和材料。 涂层包含季胺基，因此赋予基底抗菌性能。 在一个实施方案中，例如，提供了包含丙烯和乙烯重复单元的含季铵的聚合物涂层。
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5.发明公开BATCH-FABRICATED FLEXIBLE INTRAOCULAR RETINAL PROSTHESIS SYSTEMS AND METHODS FOR MANUFACTURING THE SAME 审中-公开桩生产中产生的灵活的眼内人工视网膜系统和其生产方法
公开(公告)号：EP1879645A4
公开(公告)日：2009-11-04
申请号：EP06751676
申请日：2006-04-28
发明人： TAI YU-CHONG , RODGER DAMIEN C , LI WEN , HUMAYUN MARK , WEILAND JAMES D , AMERI HOSSEIN
CPC分类号： A61N1/0543 , A61F9/08 , A61N1/36046 , Y10T29/49002 , Y10T29/49128 , Y10T29/4913 , Y10T29/49156 , Y10T29/49224
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6.发明公开METHOD OF CRYOPRESERVATION OF STEM CELL-DERIVED RETINAL PIGMENT EPITHELIAL CELLS ON POLYMERIC SUBSTRATE 审中-公开低温保存从干细胞的方法获得的视网膜色素上皮上的聚合物衬底
公开(公告)号：EP2702135A4
公开(公告)日：2015-01-28
申请号：EP12776772
申请日：2012-04-27
发明人： ZHU DANHONG , HINTON DAVID , AHUJA ASHISH , HUMAYUN MARK
IPC分类号： A01N1/02
CPC分类号： A01N1/0252 , A01N1/0268 , A01N1/0284 , A61L27/16 , A61L27/34 , A61L27/3813 , A61L27/3834 , A61L27/58 , C12N5/0621
摘要： Disclosed herein are methods and compositions for the cryopreservation of stem cells, such as stem-cell derived retinal pigment epithelial cells, that have been seeded onto and cultured on a substrate, such as a polymeric substrate. Such cryopreserved stem cells are useful for cell therapies, such as treatment of ocular damage or disease.
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