公开(公告)号：EP3229842A4

公开(公告)日：2018-07-25

申请号：EP15866947

申请日：2015-12-08

申请人： UNIV TEXAS

发明人： SIEGWART DANIEL J ,  HAO JING ,  ZHOU KEJIN ,  MILLER JASON ,  KOS PETRA ,  XUE LIAN

IPC分类号： A61K47/32 ,  A61K9/00 ,  A61K9/51 ,  A61K31/713 ,  A61K47/22 ,  A61K47/24 ,  A61K47/28 ,  A61K47/34 ,  C08G63/688 ,  C08G63/91 ,  C08G65/48 ,  C12N15/113

CPC分类号： A61K47/34 ,  A61K9/0019 ,  A61K9/5153 ,  A61K31/713 ,  A61K47/22 ,  A61K47/24 ,  A61K47/28 ,  C08G63/688 ,  C08G63/912 ,  C08G65/48 ,  C12N15/113 ,  C12N2310/14

摘要： Polymers produced by ring opening polymerization which comprises an amino group that can be used in compositions to deliver a nucleic acid such as a miRNA or a siRNA. In some embodiments, compositions which comprise the polymers described herein and a nucleic acid are also provided herein. In some embodiments, these compositions are used to silence one or more genes in vivo or treat a disease or disorder.