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公开(公告)号：EP3209299A4
公开(公告)日：2018-04-04
申请号：EP15852998
申请日：2015-10-21
发明人： BREKKEN ROLF A , DING KE , REN XIAOMEI , TU ZHENGCHAO , WANG ZHEN , AGUILERA KRISTINA Y
IPC分类号： A61K31/535 , A61P35/00
CPC分类号： C07D401/14 , A61K31/337 , A61K31/4725 , A61K31/7068 , A61K45/06 , A61K2300/00 , C07D401/04
摘要： Compounds of formula (I), their pharmaceutically acceptable salts and stereoisomers thereof, as well as application in effectively inhibiting the enzymatic activity of discoidin domain receptor 1 and can be used as new therapeutic agents for preventing and treating e.g. inflammation, liver fibrosis, kidney fibrosis, lung fibrosis, skin scar, atherosclerosis, and cancer. The compound of formula I is: wherein the variables are as defined herein.
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公开(公告)号：EP3225619A4
公开(公告)日：2018-05-23
申请号：EP15863532
申请日：2015-11-18
发明人： DING KE , DING JIAN , CHAN SHINGPAN , GENG MEIYU , REN XIAOMEI , XIE HUA , TU ZHENGCHAO , CHEN YI
IPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , A61P35/00 , A61P35/02 , C07D239/47 , C07D401/02 , C07D403/12
CPC分类号： C07D403/12 , A61K31/4523 , A61K31/505 , A61K31/506 , A61K31/53 , A61K31/5377 , A61K31/551 , C07D239/47 , C07D239/48 , C07D401/02 , C07D401/12
摘要： Disclosed are a 2-aminopyrimidine compound and pharmaceutical composition and use thereof. The structure of the 2-aminopyrimidine compound is as represented by formula I, in the formula, R 1 , R 2 , R 3 , R 4 , R 5 , X, Y, Z, W, (i) being as defined in the specification and the claims. Such compounds effectively inhibit the growth of a variety of tumor cells and have inhibitory effects on EGFR and IGF1R protease, and can be used for preparing antineoplastic drugs and overcome the tolerance induced by the existing drugs such as gefitinib, erlotinib and the like. The compound has selectivity for tumors, in particular the wild-type non-small cell lung cancer and have good pharmacokinetic characteristics.
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3.发明公开THE COMPOUNDS AS THE ESTROGEN RELATED RECEPTORS MODULATORS AND THE USES THEREOF 审中-公开AS与雌激素有关受体调节剂的化合物及其用途
公开(公告)号：EP2266962A4
公开(公告)日：2011-12-07
申请号：EP09719079
申请日：2009-03-05
发明人： DING KE , WONG CHIWAI , KANG ZHANFANG , ZHOU XI
IPC分类号： C07D239/88 , A61K31/517 , A61K31/519 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , C07D239/86 , C07D239/90 , C07D239/91 , C07D471/04 , C07D487/04
CPC分类号： C07D239/86 , C07D239/90 , C07D239/91 , C07D471/04 , C07D487/04
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公开(公告)号：EP2314588A4
公开(公告)日：2012-03-07
申请号：EP09797343
申请日：2009-03-06
发明人： DING KE , WONG CHIWAI , PENG LIJIE , KANG ZHANFANG , ZHOU XI
IPC分类号： C07D471/04 , A61K31/517 , A61K31/519 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10
CPC分类号： C07D471/04
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5.发明公开HETEROCYCLIC ALKYNYL BENZENE COMPOUNDS AND MEDICAL COMPOSITIONS AND USES THEREOF 审中-公开杂环ALKINYLBENZOLVERBINDUNGEN和医疗组合物，其及其用途
公开(公告)号：EP2594567A4
公开(公告)日：2015-03-11
申请号：EP11800049
申请日：2011-06-03
发明人： DING KE , WANG DEPING , PEI DUANQING , ZHANG ZHANG , SHEN MENGJIE , LUO KUN , FENG YUBING
IPC分类号： C07D403/12 , A61K31/437 , A61K31/4439 , A61K31/496 , A61K31/506 , A61K31/519 , A61P35/00 , A61P35/02 , C07D239/42 , C07D401/12 , C07D471/04 , C07D487/04
CPC分类号： C07D401/12 , C07D239/42 , C07D403/12 , C07D471/04 , C07D487/04
摘要： The heterocyclic alkynyl benzene compounds of formula (I), their pharmaceutically acceptable salts and stereoisomers thereof, as well as application in preparing drugs for preventing or treating tumors. The compounds can overcome the clinically induced resistance against Gleevec.
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6.发明公开PYRIMIDOPYRIMIDONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF 审中-公开PYRIMIDOPYRIMIDONDERIVATE，药物组合物及用途
公开(公告)号：EP2746283A4
公开(公告)日：2014-11-05
申请号：EP11867338
申请日：2011-12-21
发明人： DING KE , CHANG SHAOHUA , XU SHILIN , ZHANG LIANWEN , TU ZHENGCHAO , DING JIAN , GENG MEIYU , CHEN YI
IPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/551 , A61P35/00 , A61P35/02
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/551
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