公开(公告)号：EP3209299A4

公开(公告)日：2018-04-04

申请号：EP15852998

申请日：2015-10-21

申请人： UNIV TEXAS ,  GUANGZHOU INST BIOMED & HEALTH

发明人： BREKKEN ROLF A ,  DING KE ,  REN XIAOMEI ,  TU ZHENGCHAO ,  WANG ZHEN ,  AGUILERA KRISTINA Y

IPC分类号： A61K31/535 ,  A61P35/00

CPC分类号： C07D401/14 ,  A61K31/337 ,  A61K31/4725 ,  A61K31/7068 ,  A61K45/06 ,  A61K2300/00 ,  C07D401/04

摘要： Compounds of formula (I), their pharmaceutically acceptable salts and stereoisomers thereof, as well as application in effectively inhibiting the enzymatic activity of discoidin domain receptor 1 and can be used as new therapeutic agents for preventing and treating e.g. inflammation, liver fibrosis, kidney fibrosis, lung fibrosis, skin scar, atherosclerosis, and cancer. The compound of formula I is: wherein the variables are as defined herein.