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1.发明公开MANIPULATION OF NON-TERMINALLY DIFFERENTIATED CELLS USING THE NOTCH PATHWAY 失效不是最终的分化细胞下的使用NOTCH-WAY操纵
公开(公告)号：EP0948348A4
公开(公告)日：2002-05-22
申请号：EP96933960
申请日：1996-09-27
申请人： UNIV YALE
IPC分类号： C12N15/09 , A61K31/00 , A61K35/12 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P43/00 , C07K14/47 , C12N5/00 , C12N5/07 , C12N5/0797 , C12N5/10 , C12P21/02 , C12N5/08 , A61K38/17
CPC分类号： C12N5/0623 , A61K35/12 , A61K38/00 , C07K14/47 , C12N5/0018 , C12N5/0601 , C12N2501/42
摘要： The present invention is directed to methods for the expansion of non-terminally differentiated cells ("precursor cells") using agonists of Notch function, by inhibiting the differentiation of the cells without inhibiting proliferation (mitotic activity) such that an expanded population of non-terminally differentiated cells is obtained. The cells are preferably stem or progenitor cells. These expanded cells can be used in cell replacement therapy to provide desired cell populations and help in the regeneration of diseased and/or injured tissues. The expanded cell populations can also be made recombinant and used for gene therapy, or can be used to supply functions associated with a particular precursor cell or its progeny cell.
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2.发明公开VERTEBRATE DELTEX PROTEINS, NUCLEIC ACIDS, AND ANTIBODIES, AND RELATED METHODS AND COMPOSITIONS 失效DELTEX蛋白质，核酸，和脊椎动物的抗体及相关的方法和组合物
公开(公告)号：EP0869802A4
公开(公告)日：2001-11-14
申请号：EP96942785
申请日：1996-11-22
申请人： UNIV YALE
IPC分类号： G01N33/50 , A61K31/00 , A61K31/70 , A61K31/7088 , A61K35/12 , A61K35/76 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P11/00 , A61P15/00 , A61P35/00 , C07K7/04 , C07K14/07 , C07K14/47 , C07K16/18 , C07K19/00 , C12N1/19 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/566 , G01N33/577 , C07H17/00 , C07K1/00 , C07K14/00 , C07K16/00 , C12N1/00 , C12N5/00 , C12N15/00 , C12Q1/00
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