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公开(公告)号：EP2220088A2
公开(公告)日：2010-08-25
申请号：EP08847147.9
申请日：2008-11-05
发明人： SCOLASTICO, Carlo , MANZONI, Leonardo, Pierpaolo , SENECI, Pierfausto , BELVISI, Laura , DELIA, Domenico , BOLOGNESI, Martino , MASTRANGELO, Eloise , MILANI, Mario De Mayo De Mari , MOTTO, Llaria , DRAGO, Carmelo
IPC分类号： C07D487/04 , A61K31/5517 , A61P35/00
CPC分类号： C07D487/04 , C07K5/0808
摘要： The present invention relates to compounds conformationally constrained mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients.
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公开(公告)号：EP4359391A1
公开(公告)日：2024-05-01
申请号：EP22738012.8
申请日：2022-06-23
IPC分类号： C07D251/46 , C07D495/04 , C07D401/06 , C07D401/14 , C07D403/12 , A61P25/00 , A61P31/00 , A61P35/00 , A61K31/53
CPC分类号： C07D251/46 , C07D403/12 , C07D495/04 , C07D401/06 , C07D401/14 , A61P25/00 , A61P35/00 , A61P31/00
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3.发明公开NEW HOMO- AND HETERODIMERIC SMAC MIMETIC COMPOUNDS AS APOPTOSIS INDUCERS 有权HOMO和表格异MIME SMAC化合物作为细胞凋亡诱导剂
公开(公告)号：EP2817322A2
公开(公告)日：2014-12-31
申请号：EP12865538.8
申请日：2012-02-20
申请人： Universita' degli Studi di Milano , Fondazione IRCCS Istituto Nazionale dei Tumori , CISI Scrl , Fondazione Cariplo
发明人： SENECI, Pierfausto , BELVISI, Laura , COSSU, Federica , DELIA, Domenico , DRAGO, Carmelo , LECIS, Daniele , MAIORANA, Stefano , MANZONI, Leonardo, Pierpaolo , MASTRANGELO, Eloise , MILANI DE MAYO DE MARI, Mario , PEREGO, Paola Maria Chiara , VASILE, Francesca
IPC分类号： C07K5/083 , C07D487/04 , A61P35/00 , A61K31/5517
CPC分类号： A61K38/07 , A61K38/00 , A61K38/06 , A61K45/06 , C07D519/00 , C07K5/0804 , C07K5/0806 , C07K5/0808 , C07K5/1005 , C07K5/1008 , C07K5/101
摘要： The present invention relates to conformationally constrained homo- and heterodimeric mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients.
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公开(公告)号：EP3468950A1
公开(公告)日：2019-04-17
申请号：EP17737371.9
申请日：2017-06-14
申请人： Universita' degli Studi di Milano , Università Degli Studi Di Trento , Università Degli Studi di Napoli "Federico II"
发明人： PROVENZANI, Alessandro , D' AGOSTINO, Vito Giuseppe , THONGON, Natthakan , ZUCAL, Chiara , LAL, Preet , ADAMI, Valentina , SENECI, Pierfausto , MANZONI, Leonardo , MARINELLI, Luciana , NOVELLINO, Ettore , FRAGAI, Marco , LUCHINAT, Claudio , CEROFOLINI, Linda , FUCCIO, Carmelo
IPC分类号： C07D209/08
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5.发明授权HOMO- AND HETERODIMERIC SMAC MIMETIC COMPOUNDS AS APOPTOSIS INDUCERS 有权HOMO和表格异MIME SMAC化合物作为细胞凋亡诱导剂
公开(公告)号：EP2817322B1
公开(公告)日：2016-04-20
申请号：EP12865538.8
申请日：2012-02-20
申请人： Universita' degli Studi di Milano , Fondazione IRCCS Istituto Nazionale dei Tumori , CISI Scrl , Fondazione Cariplo
发明人： SENECI, Pierfausto , BELVISI, Laura , COSSU, Federica , DELIA, Domenico , DRAGO, Carmelo , LECIS, Daniele , MAIORANA, Stefano , MANZONI, Leonardo, Pierpaolo , MASTRANGELO, Eloise , MILANI DE MAYO DE MARI, Mario , PEREGO, Paola Maria Chiara , VASILE, Francesca
IPC分类号： C07K5/083 , C07K5/103 , C07D487/04 , A61P35/00 , A61K31/5517
CPC分类号： A61K38/07 , A61K38/00 , A61K38/06 , A61K45/06 , C07D519/00 , C07K5/0804 , C07K5/0806 , C07K5/0808 , C07K5/1005 , C07K5/1008 , C07K5/101
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