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    PROCEDE DE PREPARATION DE NANOPARTICULES LIPIDIQUES
    2.
    发明公开
    PROCEDE DE PREPARATION DE NANOPARTICULES LIPIDIQUES 有权
    用于生产脂质纳米粒

    公开(公告)号：EP2376218A1

    公开(公告)日：2011-10-19

    申请号：EP09803843.3

    申请日：2009-12-11

    申请人： UNIVERSITE D'ANGERS ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

    发明人： BENOIT, Jean-Pierre ,  THOMAS, Olivier ,  RAMADAN, Alyaa, Adel ,  SAULNIER, Patrick

    IPC分类号： B01J13/04

    CPC分类号： B01J13/04

    摘要： The present invention relates to a useful method for preparing nanocapsules with a liquid lipid core and a hard shell and loaded with at least one hydrophilic active agent, said method including at least the steps of: i) using at least one first water-in-oil microemulsion containing, in the hydrophilic phase thereof, at least one hydrophilic active agent; ii) using at least one second microemulsion that is formulated by the phase inversion of an emulsion; iii) adding said first microemulsion into said second microemulsion under conditions that are conducive to the formation of a novel microemulsion architecture wherein said hydrophilic active agent remains present in the hydrophilic phase of the first microemulsion; and iv) quenching the mixture that is formed in the preceding step so as to obtain microcapsules containing said hydrophilic active agent and being made of a lipid core that is liquid at room temperature and coated in a hard film at room temperature. The invention also relates to nanocapsules obtainable by said method.

    FILAMENTS DE POLYMERE POUR UNE UTILISATION EN TANT QUE DOSIMETRE THERMOLUMINESCENT
    10.
    发明公开
    FILAMENTS DE POLYMERE POUR UNE UTILISATION EN TANT QUE DOSIMETRE THERMOLUMINESCENT 审中-公开
    聚合物丝及其作为热释光

    公开(公告)号：EP1163538A1

    公开(公告)日：2001-12-19

    申请号：EP00914249.8

    申请日：2000-03-24

    申请人： MAINELAB ,  UNIVERSITE D'ANGERS

    发明人： MARTIN, Stéphane ,  BARDIES, Manuel ,  LISBONA, Albert ,  MORTEAU, Sophie ,  RICHARD, Jo[l ,  BENOIT, Jean-Pierre ,  DENIZOT, Benoît

    IPC分类号： G01T1/11

    CPC分类号： G01T1/11 ,  Y10T428/2913 ,  Y10T428/2927

    摘要： The invention relates to a filament comprising thermoluminescent particles that are evenly distributed in a polymer matrix, characterized in that the polymer matrix is a thermoplastic polymer having sufficient adhesion with respect to said thermoluminescent particles in order to ensure the cohesion of said filament and being such that the thermoluminescent response (signal) of the filament corresponds substantially to the dose of radiation absorbed and obtained after the filament is placed in contact with a physiological medium. The invention also relates to a method for thermoluminescence-based measurement of doses of beta radiation delivered by a transmitter on a target organ of a mammal, characterized in that a group of inventive filaments is introduced to the desired spot, whereby part of the length of said filaments remains outside the irradiated area, and in that the filaments are removed after irradiation and thermoluminescence is determined.