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公开(公告)号：EP2376218A1
公开(公告)日：2011-10-19
申请号：EP09803843.3
申请日：2009-12-11
IPC分类号： B01J13/04
CPC分类号： B01J13/04
摘要： The present invention relates to a useful method for preparing nanocapsules with a liquid lipid core and a hard shell and loaded with at least one hydrophilic active agent, said method including at least the steps of: i) using at least one first water-in-oil microemulsion containing, in the hydrophilic phase thereof, at least one hydrophilic active agent; ii) using at least one second microemulsion that is formulated by the phase inversion of an emulsion; iii) adding said first microemulsion into said second microemulsion under conditions that are conducive to the formation of a novel microemulsion architecture wherein said hydrophilic active agent remains present in the hydrophilic phase of the first microemulsion; and iv) quenching the mixture that is formed in the preceding step so as to obtain microcapsules containing said hydrophilic active agent and being made of a lipid core that is liquid at room temperature and coated in a hard film at room temperature. The invention also relates to nanocapsules obtainable by said method.
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3.发明公开NANOCAPSULES A COEUR LIPIDIQUE LIQUIDE CHARGEES EN ACTIF(S) HYDROSOLUBLE(S) OU HYDRODISPERSIBLE(S) 审中-公开用水溶性或水分散性成分的液体脂质核心纳米胶囊
公开(公告)号：EP2167053A2
公开(公告)日：2010-03-31
申请号：EP08805977.9
申请日：2008-06-11
申请人： UNIVERSITE D'ANGERS
CPC分类号： A61K9/5123 , A61K9/1075
摘要： The invention relates to nanocapsules with a liquid lipidic core and a solid lipidic shell, the lipidic core being loaded with at least one water-soluble or water-dispersible ingredient, said ingredient being present in the form of a reverse micellar system.
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4.发明授权NANOCAPSULES LIPIDIQUES, PROCEDE DE PREPARATION ET UTILISATION COMME MEDICAMENT 有权脂质纳米胶囊，其制造方法和用途医药
公开(公告)号：EP1265698B1
公开(公告)日：2004-06-16
申请号：EP01911828.0
申请日：2001-03-02
申请人： MAINELAB , UNIVERSITE D'ANGERS
发明人： HEURTAULT, Béatrice , SAULNIER, Patrick , BENOIT, Jean-Pierre , PROUST, Jacques-Emile , PECH, Brigitte , RICHARD, Joel
CPC分类号： A61K9/5123 , A61K9/5146 , B01F17/0028 , B01F17/0064 , B01F17/0085 , B01J13/0026 , B01J13/06
摘要： The invention concerns nanocapsules, in particular with an average size less than 50 nm, consisting of an essentially lipid core liquid or semiliquid at room temperature, coated with an essentially lipid film solid at room temperature having a thickness of 2 - 10 nm. The invention also concerns a method for preparing same which consists in producing a reverse phase of an aqueous emulsion brought about by several temperature raising and lowering cycles. Said lipid nanocapsules are particularly designed for producing a medicine.
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公开(公告)号：EP2167054A2
公开(公告)日：2010-03-31
申请号：EP08805978.7
申请日：2008-06-11
申请人： UNIVERSITE D'ANGERS
IPC分类号： A61K9/51
CPC分类号： A61K9/5123 , A61K9/1075 , A61K31/192 , A61K31/70
摘要： The present invention relates to a method for use in the preparation of nanocapsules which have a liquid lipid core and a solid lipid shell and which are loaded with at least one active agent, wherein said method comprises at least the steps consisting in providing a microemulsion formulated by phase inversion of an emulsion, providing a second composition, distinct from said microemulsion and completely or partly formed from at least one active agent, placing said microemulsion in the presence of said second composition under conditions suitable for the interaction of said active agent with said microemulsion and annealing said microemulsion having interacted with said active agent in such a way as to obtain said nanocapsules. The invention also relates to a corresponding kit.
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6.发明公开NANOCAPSULES LIPIDIQUES, PROCEDE DE PREPARATION ET UTILISATION COMME MEDICAMENT 有权脂质纳米胶囊，其制造方法和用途医药
公开(公告)号：EP1265698A1
公开(公告)日：2002-12-18
申请号：EP01911828.0
申请日：2001-03-02
申请人： MAINELAB , UNIVERSITE D'ANGERS
发明人： HEURTAULT, Béatrice , SAULNIER, Patrick , BENOIT, Jean-Pierre , PROUST, Jacques-Emile , PECH, Brigitte , RICHARD, Joel
CPC分类号： A61K9/5123 , A61K9/5146 , B01F17/0028 , B01F17/0064 , B01F17/0085 , B01J13/0026 , B01J13/06
摘要： The invention concerns nanocapsules, in particular with an average size less than 50 nm, consisting of an essentially lipid core liquid or semiliquid at room temperature, coated with an essentially lipid film solid at room temperature having a thickness of 2 - 10 nm. The invention also concerns a method for preparing same which consists in producing a reverse phase of an aqueous emulsion brought about by several temperature raising and lowering cycles. Said lipid nanocapsules are particularly designed for producing a medicine.
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