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1.发明公开ISOLATED PEPTIDES AND FRAGMENTS THEREOF FROM FIBRINOGEN FOR USE AS DRUGS, PARTICULARLY IN SKIN INFLAMMATORY DISEASES 审中-公开由纤维蛋白原分离的多肽及其片段，用作药物，特别是皮肤炎性疾病
公开(公告)号：EP3270950A1
公开(公告)日：2018-01-24
申请号：EP16713796.7
申请日：2016-03-21
申请人： UNIVERSITE PARIS DESCARTES , Assistance Publique-Hôpitaux de Paris , Universite Paris-Sud , Université Pierre et Marie Curie (Paris 6) , Institut National de la Santé et de la Recherche Médicale (INSERM) , Centre National de la Recherche Scientifique (CNRS) , Institut Gustave Roussy
CPC分类号： C07K14/75 , A61K9/0014 , A61K9/0019 , A61K38/00 , A61P17/06 , A61P17/10 , A61P29/00 , C07K2319/00 , C12N7/00
摘要： A present invention relates to isolated peptides obtained from human fibrinogen for their use as drug, particularly for the prevention and/or the treatment of inflammatory skin diseases, more particularly acne. The present invention also relates to fragments of these polypeptides, nucleic acid molecules encoding them, expression vectors, host cells, a pharmaceutical composition and a combination product containing them, and their use for treating and/or preventing inflammatory skin diseases, particularly acne.
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2.发明授权
公开(公告)号：EP3148537B1
公开(公告)日：2018-09-26
申请号：EP15745154.3
申请日：2015-05-29
申请人： Université Paris Descartes , Centre National de la Recherche Scientifique (CNRS) , Université Pierre et Marie Curie (Paris 6) , Institut National de la Santé et de la Recherche Médicale (INSERM) , Assistance Publique Hôpitaux de Paris
发明人： MICOUIN, Laurent , BLOND, Aurélie , CALVEZ, Vincent , MARCELLIN, Anne-Geneviève , SOULIE, Cathia , CORROT, Emilie
IPC分类号： A61K31/4192 , A61K31/445 , A61K31/451 , A61K31/454 , A61P31/18
CPC分类号： C07D211/56 , A61K31/4192 , A61K31/427 , A61K31/439 , A61K31/445 , A61K31/451 , A61K31/4525 , A61K31/454 , A61K31/505 , A61K31/513 , A61K31/52 , A61K31/536 , A61K31/55 , A61K31/675 , A61K31/7072 , A61K45/06 , C07D401/04 , C07D401/06 , C07D405/06 , A61K2300/00
摘要： The present invention relates to compounds, capable of activating HIV expression in reservoir cells, of formula (I) for use in the treatment of HIV infection.
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公开(公告)号：EP3474843A1
公开(公告)日：2019-05-01
申请号：EP17735077.4
申请日：2017-06-28
申请人： Assistance Publique - Hôpitaux de Paris , Institut National de la Santé et de la Recherche Médicale (INSERM) , Université Pierre et Marie Curie - Paris 6 (UPMC) , Université Paris Descartes , Centre National de la Recherche Scientifique (CNRS)
IPC分类号： A61K31/352 , A61K31/382 , A61K31/4706 , A61K45/06 , A61P31/12 , A61P31/22
摘要： The present invention relates to compounds of the following general formula (I) or (II) or a pharmaceutically acceptable salt and/or solvate thereof, for use in the prevention and/or the treatment of disorders associated to gammaherpesvirinae, in particular to the human herpesvirus 8 (HHV8) or the human herpes virus 4 (HHV4), and pharmaceutical compositions containing such compounds.
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4.发明公开CYCLIC COMPOUNDS HAVING A 1,3 DIAMINO-FUNCTIONALITY FOR USE IN THE TREATMENT OF HIV INFECTION 审中-公开带有130-DIAMINO功能，FOR USE IN HIV感染的治疗环状化合物
公开(公告)号：EP3148537A1
公开(公告)日：2017-04-05
申请号：EP15745154.3
申请日：2015-05-29
申请人： Université Paris Descartes , Centre National de la Recherche Scientifique CNRS , Université Pierre et Marie Curie (Paris 6) , Institut National de la Santé et de la Recherche Médicale (INSERM) , Assistance Publique Hôpitaux de Paris
发明人： MICOUIN, Laurent , BLOND, Aurélie , CALVEZ, Vincent , MARCELLIN, Anne-Geneviève , SOULIE, Cathia , CORROT, Emilie
IPC分类号： A61K31/4192 , A61K31/445 , A61K31/451 , A61K31/454 , A61P31/18
CPC分类号： C07D211/56 , A61K31/4192 , A61K31/427 , A61K31/439 , A61K31/445 , A61K31/451 , A61K31/4525 , A61K31/454 , A61K31/505 , A61K31/513 , A61K31/52 , A61K31/536 , A61K31/55 , A61K31/675 , A61K31/7072 , A61K45/06 , C07D401/04 , C07D401/06 , C07D405/06 , A61K2300/00
摘要： The present invention relates to compounds, capable of activating HIV expression in reservoir cells, of formula (I) for use in the treatment of HIV infection.
摘要翻译： 本发明涉及化合物，能够激活在储层单元HIV表达，式（I）为在HIV感染的治疗中的使用。
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公开(公告)号：EP3474843B1
公开(公告)日：2020-10-28
申请号：EP17735077.4
申请日：2017-06-28
申请人： Assistance Publique - Hôpitaux de Paris , Institut National de la Santé et de la Recherche Médicale (INSERM) , Sorbonne Université , Université Paris Descartes , Centre National de la Recherche Scientifique (CNRS)
IPC分类号： A61K31/352 , A61K31/382 , A61K31/4706 , A61K45/06 , A61P31/12 , A61P31/22
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公开(公告)号：EP3484476A1
公开(公告)日：2019-05-22
申请号：EP17745143.2
申请日：2017-07-13
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公开(公告)号：EP3943088A1
公开(公告)日：2022-01-26
申请号：EP21184745.4
申请日：2017-07-13
申请人： Université de Paris , ASSISTANCE PUBLIQUE, HOPITAUX DE PARIS , SORBONNE UNIVERSITE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , Institut National de la Santé et de la Recherche Médicale (INSERM)
摘要： The present invention relates to compounds of the following general formula (I) or (II):
or a pharmaceutically acceptable salt and/or solvate thereof, for use in the prevention and/or the treatment of disorders associated to the inflammation induced by P. acnes, in particular in the prevention and/or the treatment of acne, psoriasis, chronic urticaria, urticaria pigmentosa, cutaneous autoinflammatory diseases, hidradenitis or atopic dermatis.-
公开(公告)号：EP4153158A1
公开(公告)日：2023-03-29
申请号：EP21725548.8
申请日：2021-05-18
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Assistance Publique-Hôpitaux de Paris (APHP) , Sorbonne Université , Université Paris Cité , Université Paris-Est Créteil Val de Marne
发明人： VILLOUTREIX, Bruno , BEAUNE, Philippe , LEBOYER, Marion , TAMOUZA, Ryad , KRISHNAMOORTHY, Rajagopal , CALVEZ, Vincent , MARCELIN, Anne-Geneviève
IPC分类号： A61K31/135 , A61K31/19 , A61K31/343 , A61K31/4045 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/5415 , A61K31/55 , A61K31/5513 , A61K31/554 , A61K33/00 , A61P31/14 , A61K45/06
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公开(公告)号：EP3507309B1
公开(公告)日：2020-09-30
申请号：EP16762775.1
申请日：2016-09-05
申请人： SORBONNE UNIVERSITE , Centre National de la Recherche Scientifique , Institut National de la Santé et de la Recherche Médicale (INSERM) , Assistance Publique - Hôpitaux De Paris , Université Paris Descartes
发明人： SOLLOGOUB, Matthieu , CALVEZ, Vincent , MARCELIN, Anne-Geneviève , BOUTEILLER, Laurent , MENAND, Mickaël , EVENOU, Pierre , GOTHLAND, Adélie , COLESNIC, Dmitri , ROSSIGNOL, Julien
IPC分类号： C08B37/16
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公开(公告)号：EP3507309A1
公开(公告)日：2019-07-10
申请号：EP16762775.1
申请日：2016-09-05
申请人： SORBONNE UNIVERSITE , Centre National de la Recherche Scientifique , Institut National de la Santé et de la Recherche Médicale (INSERM) , Assistance Publique - Hôpitaux De Paris , Université Paris Descartes
发明人： SOLLOGOUB, Matthieu , CALVEZ, Vincent , MARCELIN, Anne-Geneviève , BOUTEILLER, Laurent , MENAND, Mickaël , EVENOU, Pierre , GOTHLAND, Adélie , COLESNIC, Dmitri , ROSSIGNOL, Julien
IPC分类号： C08B37/16
摘要： The invention relates to a capped cyclodextrin-hydrophobic moiety conjugate, to a supramolecular polymer formed of capped cyclodextrin-hydrophobic moiety conjugates according to the invention and to a siRNA-cyclodextrin complex comprising a supramolecular polymer according to the invention. The invention also relates to a method for manufacturing the capped cyclodextrin-hydrophobic moiety conjugate, the supramolecular polymer, the siRNA-cyclodextrin complex according to the invention. The capped cyclodextrin-hydrophobic moiety conjugate of the invention comprises a capped cyclodextrin group and at least one hydrophobic moiety bound by a first linker to one of the carbon atoms of the cap. The invention can be used for various applications in particular in the pharmaceutical field.
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