公开(公告)号：EP0286433B1

公开(公告)日：1992-10-21

申请号：EP88303172.6

申请日：1988-04-08

申请人： UNIVERSITY OF FLORIDA

发明人： Goldberg, Eugene P. Dept. Materials Science ,  Osborn, David C. ,  Kumar, Sudesh, G. ,  Larson, Jeffrey A. ,  Sheets, John W. ,  Burns, James W.

IPC分类号： A61L27/00 ,  A61F2/16 ,  C08J7/18

CPC分类号： A61L27/50 ,  A61F2/14 ,  A61F2002/16903 ,  A61L27/16 ,  A61L2400/18 ,  A61L2430/16 ,  C08J7/18 ,  A61F2/16 ,  C08L51/06

摘要： A method for modifying a PMMA surface by the gamma-irradiation induced polymerization thereon of N-vinylpyrrolidone, 2-hydroxyethylmethacrylate or a mixture thereof while maintaining the following conditions: a) monomer concentration in the range of from about 0.5% to about 50%, by weight; b) total gamma dose in the range of from about 0.01 to less than about 0.50 Mrad; c) gamma dose rate in the range of from about 10 to about 2500 rads/minute; and d) maintaining the molecular weight of the polymer in solution in the range of from about 250,000 to about 5,000,000. The invention also relates to modifying polypropylene, polyvinylidene fluoride, polycarbonate and silicone surfaces according to a similar method as well as materials produced by the above methods which are useful as ocular implants.

公开(公告)号：EP0667755A4

公开(公告)日：1996-03-27

申请号：EP94922529

申请日：1994-07-11

申请人： KABI PHARMACIA OPTHALMICS INC

发明人： RHEINISH ROBERT SCOTT ,  TONKS ALLAN R ,  RICHARDS THOMAS P

IPC分类号： A61F2/16

CPC分类号： A61F2/16 ,  A61F2002/1681 ,  A61F2002/1683 ,  A61F2002/16903 ,  A61F2002/16905

摘要： An intraocular lens (10) includes an optic body (12), and a pair of diametrically oppositely disposed elongate support haptics (14) extending radially outwardly and circumferentially on the optic body (12) to define a distal end foot portion (22) supportingly engageable with eye tissue and terminating in a distal (24) end for the haptic. In a first position for the haptics, the distal end foot portions (22) are spaced from the optic body (12). One of the optic body (12) and support haptic (14) defines releasable constraining features for engaging one of the optic body (12) or the other of the pair of haptics (14) to constrain the haptic (14) in a second position in which the distal end foot portion (22) thereof is adjacent to the optic body (12). In the second configuration of the intraocular lens (10) it is possible to pass the lens (10) into an eye via a surgical incision only slightly larger than the size of the optic body.

公开(公告)号：EP0667755A1

公开(公告)日：1995-08-23

申请号：EP94922529.0

申请日：1994-07-11

申请人： KABI PHARMACIA OPTHALMICS, INC.

发明人： RHEINISH, Robert, Scott ,  TONKS, Allan, R. ,  RICHARDS, Thomas, P.

IPC分类号： A61F2

CPC分类号： A61F2/16 ,  A61F2002/1681 ,  A61F2002/1683 ,  A61F2002/16903 ,  A61F2002/16905

摘要： An intraocular lens (10) includes an optic body (12), and a pair of diametrically oppositely disposed elongate support haptics (14) extending radially outwardly and circumferentially on the optic body (12) to define a distal end foot portion (22) supportingly engageable with eye tissue and terminating in a distal (24) end for the haptic. In a first position for the haptics, the distal end foot portions (22) are spaced from the optic body (12). One of the optic body (12) and support haptic (14) defines releasable constraining features for engaging one of the optic body (12) or the other of the pair of haptics (14) to constrain the haptic (14) in a second position in which the distal end foot portion (22) thereof is adjacent to the optic body (12). In the second configuration of the intraocular lens (10) it is possible to pass the lens (10) into an eye via a surgical incision only slightly larger than the size of the optic body.

公开(公告)号：EP0286433A3

公开(公告)日：1990-03-14

申请号：EP88303172.6

申请日：1988-04-08

申请人： UNIVERSITY OF FLORIDA

发明人： Goldberg, Eugene P. Dept. Materials Science ,  Osborn, David C. ,  Kumar, Sudesh, G. ,  Larson, Jeffrey A. ,  Sheets, John W. ,  Burns, James W.

IPC分类号： A61L27/00 ,  A61F2/16 ,  C08J7/18

CPC分类号： A61L27/50 ,  A61F2/14 ,  A61F2002/16903 ,  A61L27/16 ,  A61L2400/18 ,  A61L2430/16 ,  C08J7/18 ,  A61F2/16 ,  C08L51/06

摘要： A method for modifying a PMMA surface by the gamma-irradiation induced polymerization thereon of N-­vinylpyrrolidone, 2-hydroxyethylmethacrylate or a mixture thereof while maintaining the following conditions:
a) monomer concentration in the range of from about 0.5% to about 50%, by weight; b) total gamma dose in the range of from about 0.01 to less than about 0.50 Mrad; c) gamma dose rate in the range of from about 10 to about 2500 rads/minute; and d) maintaining the molecular weight of the polymer in solution in the range of from about 250,000 to about 5,000,000. The invention also relates to modifying polypropylene, polyvinylidene fluoride, polycarbonate and silicone surfaces according to a similar method as well as materials produced by the above methods which are useful as ocular implants.

公开(公告)号：EP2579814B1

公开(公告)日：2017-03-01

申请号：EP11792588.3

申请日：2011-06-08

申请人： Hoya Corporation

发明人： KUDO, Kazunori ,  NODA, Masahiro

IPC分类号： A61F2/16 ,  A61F2/00

CPC分类号： A61F2/1672 ,  A61F2/0095 ,  A61F2/148 ,  A61F2/1662 ,  A61F2/1664 ,  A61F2/1667 ,  A61F2/167 ,  A61F2/1678 ,  A61F2/1691 ,  A61F9/0008 ,  A61F9/0017 ,  A61F2002/1681 ,  A61F2002/16903

摘要： An exemplary ocular implant insertion system includes a case and a preloaded ocular implant insertion apparatus. The apparatus includes first and second movable structures that move the ocular implant in a predetermined sequence. The respective configurations of the case and the ocular implant insertion apparatus are such that the ocular implant insertion apparatus is not removable from the case when the ocular implant insertion apparatus is in the pre-use state and is removable after the first movable structure has moved at least a portion of the optical implant.

公开(公告)号：EP2579814A1

公开(公告)日：2013-04-17

申请号：EP11792588.3

申请日：2011-06-08

申请人： Hoya Corporation

发明人： KUDO, Kazunori ,  NODA, Masahiro

IPC分类号： A61F2/16 ,  A61F9/007

CPC分类号： A61F2/1672 ,  A61F2/0095 ,  A61F2/148 ,  A61F2/1662 ,  A61F2/1664 ,  A61F2/1667 ,  A61F2/167 ,  A61F2/1678 ,  A61F2/1691 ,  A61F9/0008 ,  A61F9/0017 ,  A61F2002/1681 ,  A61F2002/16903

摘要： An exemplary ocular implant insertion system includes a case and a preloaded ocular implant insertion apparatus. The apparatus includes first and second movable structures that move the ocular implant in a predetermined sequence. The respective configurations of the case and the ocular implant insertion apparatus are such that the ocular implant insertion apparatus is not removable from the case when the ocular implant insertion apparatus is in the pre-use state and is removable after the first movable structure has moved at least a portion of the optical implant.

摘要翻译： 示例性眼部植入物插入系统包括壳体和预加载的眼部植入物插入装置。 该装置包括以预定顺序移动眼部植入物的第一和第二可移动结构。 外壳和眼植入物插入装置的各自结构使得眼睛植入物插入装置不能从眼睛植入物插入装置处于使用前状态的情况下移除，并且在第一可移动结构移动之后是可移除的 至少一部分光学植入物。

公开(公告)号：EP0496022A1

公开(公告)日：1992-07-29

申请号：EP91100964.5

申请日：1991-01-25

申请人： Kraff, Manus C.

发明人： Kraff, Manus C.

IPC分类号： A61F2/16

CPC分类号： A61F2/1613 ,  A61F2002/16903 ,  A61F2002/169053 ,  A61F2250/0039

摘要： An intraocular lens apparatus for replacement of the natural lens following the extraction of the natural lens in cataract surgery. One or more resilient haptics, having one or both ends affixed to the lens body, are provided with alternating regions of varying transverse cross-sectional area along their length, so as to combine a relatively narrow insertion profile with great flexibility and stability once implanted within the eye.

摘要翻译： 一种眼内透镜装置，用于在白内障手术中提取天然晶状体后更换天然晶状体。 一个或多个具有一个或两个端部固定到透镜体上的弹性触觉件沿它们的长度设置有具有变化的横截面积的交替区域，以便一旦植入在其中，就将组合具有很大柔性和稳定性的相对窄的插入轮廓 眼。

公开(公告)号：EP0200806B1

公开(公告)日：1990-10-24

申请号：EP85105679.6

申请日：1985-05-09

申请人： Heslin, Buol K.

发明人： Heslin, Buol K.

IPC分类号： A61F2/16

CPC分类号： A61F2/16 ,  A61F2/1664 ,  A61F2002/1681 ,  A61F2002/1683 ,  A61F2002/16903 ,  A61F2002/16905

公开(公告)号：EP0286433A2

公开(公告)日：1988-10-12

申请号：EP88303172.6

申请日：1988-04-08

申请人： UNIVERSITY OF FLORIDA

发明人： Goldberg, Eugene P. Dept. Materials Science ,  Osborn, David C. ,  Kumar, Sudesh, G. ,  Larson, Jeffrey A. ,  Sheets, John W. ,  Burns, James W.

IPC分类号： A61L27/00 ,  A61F2/16 ,  C08J7/18

CPC分类号： A61L27/50 ,  A61F2/14 ,  A61F2002/16903 ,  A61L27/16 ,  A61L2400/18 ,  A61L2430/16 ,  C08J7/18 ,  A61F2/16 ,  C08L51/06

摘要： A method for modifying a PMMA surface by the gamma-irradiation induced polymerization thereon of N-­vinylpyrrolidone, 2-hydroxyethylmethacrylate or a mixture thereof while maintaining the following conditions:

a) monomer concentration in the range of from about 0.5% to about 50%, by weight;
b) total gamma dose in the range of from about 0.01 to less than about 0.50 Mrad;
c) gamma dose rate in the range of from about 10 to about 2500 rads/minute; and
d) maintaining the molecular weight of the polymer in solution in the range of from about 250,000 to about 5,000,000.

The invention also relates to modifying polypropylene, polyvinylidene fluoride, polycarbonate and silicone surfaces according to a similar method as well as materials produced by the above methods which are useful as ocular implants.

摘要翻译： 通过γ-射线诱导聚合在其上的N-乙烯基吡咯烷酮，甲基丙烯酸2-羟基乙酯或其混合物来改性PMMA表面的方法，同时保持以下条件：a）单体浓度在约0.5％至约50％的范围内， 重量 b）在约0.01至小于约0.5Mrad范围内的总γ剂量; c）γ剂量率在约10至约2500rad /分钟的范围内; 和d）将聚合物在溶液中的分子量保持在约250,000至约5,000,000的范围内。 本发明还涉及根据类似方法改性聚丙烯，聚偏二氟乙烯，聚碳酸酯和硅氧烷表面，以及用作眼睛植入物的上述方法制备的材料。

公开(公告)号：EP3329880A1

公开(公告)日：2018-06-06

申请号：EP16830223.0

申请日：2016-06-29

申请人： Chukyo Medical Co., Inc.

发明人： ICHIKAWA, Kazuo ,  YOSHIDA, Norihiko

IPC分类号： A61F2/16

CPC分类号： A61F2/16 ,  A61F2/1608 ,  A61F2/1629 ,  A61F2/1664 ,  A61F2002/1681 ,  A61F2002/1682 ,  A61F2002/16903 ,  A61F2002/1699 ,  A61F2220/0016

摘要： In an eye of a patient, ciliary processes 21 project from a ciliary body 20 located in a circumferential direction about a visual axis C, toward the visual axis C. A hook portion 4 is provided which is formed so as to extend from base portions 21a of the ciliary processes 21 along the outer surfaces of the ciliary processes 21 via anterior end portions 21b of the ciliary processes 21 to base portions 21c at the opposite side. A leg portion 3 extending from the hook portion 4 toward the visual axis C is connected to the hook portion 4, and a lens 2 to be mounted in the eye of the patient is supported by the leg portion 3. The lens 2 is held in the eye of the patient in a state where the hook portion 4 is hooked or fitted to the ciliary processes 21. Accordingly, an intraocularly-mounted object and an intraocularly-mounted object holding member that are allowed to move directly in conjunction with relaxation/contraction movement of ciliary muscle, are provided.